Patents Examined by Theodore J. Criares
  • Use of retinoids to treat high blood pressure and other cardiovascular disease
    Patent number: 6437003
    Abstract: This invention provides methods of treating a disease in a mammal where the disease is characterized by a symptom ameliorated by inhibition of cellular calcium influx. The methods involve administering to the mammal an effective amount of a retinoid and a pharmacologically acceptable excipient.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: August 20, 2002
    Inventors: Jean-Baptiste Roullet, David A McCarron
  • Nasal delivery of apomorphine
    Patent number: 6436950
    Abstract: Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: August 20, 2002
    Assignee: Nastech Pharmaceutical Company, Inc.
    Inventors: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
  • Treatment for alzheimer's disease
    Patent number: 6436983
    Abstract: This invention is a method of treating a mammal, including a human, susceptible to having Alzheimer's disease, to prevent or delay the onset of Alzheimer's disease; said method comprising administering to said mammal a prophylactically effective amount of 1H-indole-3-glycoxyamide sPLA2 inhibitor or a pharmaceutically acceptable salt, solvate or prodrug derivative thereof.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: August 20, 2002
    Assignee: Eli Lilly and Company
    Inventor: August M Watanabe
  • Modulation of nitric oxide production
    Patent number: 6436996
    Abstract: A method of treating cells that carry at least one APOE4 allele comprises increasing nitric oxide levels in the cells (e.g., by administering an exogenous source of nitric oxide to the cells) by an amount sufficient to combat the decrease of nitric oxide level associated with the presence of the APOE4 allele. Also disclosed is a method of increasing nitric oxide levels in cells in need thereof which comprises administering APOE to the cells in an amount sufficient to increase nitric oxide levels in the cells.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: August 20, 2002
    Assignees: Duke University, Georgetown University
    Inventors: Michael P. Vitek, Carol A. Colton
  • Treatment of skin damage using olive oil polyphenols
    Patent number: 6437004
    Abstract: Free radical-scavenging olive oil polyphenols are topically applied to treat skin damage, such as contact dermatitis (particularly diaper area dermatitis), atopic dermatitis, xerosis, eczema (including severe hand and foot eczema), rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 0.25% to about 10% of a polyphenol preparation obtained from olive oil.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: August 20, 2002
    Inventor: Nicholas V. Perricone
  • Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients
    Patent number: 6432935
    Abstract: Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or tinidazol or nimorazol) and a pharmaceutically acceptable carrier. The compositions are useful mainly as vaginal suppositories.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: August 13, 2002
    Inventor: Márton Milánkovits
  • Compositions and methods for inhibiting bone resorption
    Patent number: 6432931
    Abstract: The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: August 13, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Alfred A. Reszka, Edward S. Scolnick
  • Cleaning composition containing naturally-derived components
    Patent number: 6432395
    Abstract: A less irritating cleaning composition is provided containing only naturally derived components. The composition preferably comprises lactic acid or other C2-C6 organic acid, alkyl polyglucoside, alkyl glucoester and collagen protein.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: August 13, 2002
    Assignee: Cogent Environmental Solutions Ltd.
    Inventors: Michael R. Rochon, Bernardus M. Tangelder
  • Method for treatment of sleep apneas
    Patent number: 6432956
    Abstract: Certain azapirone compounds and their pharmaceutically acceptable salts are useful in the treatment of sleep apneas.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: August 13, 2002
    Inventors: William C. Dement, Mark R. Rosekind, Jeffrey L. Schwimmer
  • Method for inhibiting bone resorption
    Patent number: 6432932
    Abstract: Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: August 13, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Anastasia G. Daifotis, Arthur C. Santora, II, A. John Yates
  • Treatment for joint inflammation
    Patent number: 6432937
    Abstract: The invention provides the use of a glucocorticoid substance which has a minimal systemic effect in the manufacture of a medicament for oral or rectal administration for non-topical use in the treatment of joint inflammation.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: August 13, 2002
    Assignee: Astra Aktiebolag
    Inventor: Roger Hällgren
  • Lubrication composition
    Patent number: 6428791
    Abstract: A lubricating composition for use in mucosal areas is provided to enhance sexual performance. The composition contains combination of a compound which enhances blood circulation to body parts and/or increase nitrous oxide levels at the site of administration together with a compound which can generate heat without any substantial irritation or create the feel of heat in a lubrication base. Preferably, the composition is homeopatic.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: August 6, 2002
    Assignee: Alphamed Pharmace Vticals, Corp
    Inventors: John Lezdey, Jarett Lezdey
  • Oil in water microemulsion
    Patent number: 6426078
    Abstract: The invention is concerned with a microemulsion of the oil-in water type, containing at least one polyglycerol ester as the emulsifier and at least one lipophilic substance as the internal phase. The emulsifier contains a triglycerol monofatty acid ester and the lipophilic substance is one from the group carotenoids, especially, &bgr;-carotene, vitamins A, D, E and K and their derivatives and polyunsaturated fatty acids.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: July 30, 2002
    Assignee: Roche Vitamins Inc.
    Inventors: Kurt Bauer, Clarissa Neuber, Axel Schmid, Karl Manfred Völker
  • Formulations and methods for providing prolonged local anesthesia
    Patent number: 6426339
    Abstract: The use of glucocorticosteroids in methods and formulations for prolonging and/or reactivating local anesthesia or local anesthesia previously induced by a local anesthetic agent, is disclosed.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: July 30, 2002
    Assignee: Children's Medical Center Corporation
    Inventors: Charles B. Berde, Robert S. Langer, Joanne Curley, Jenny Castillo
  • Method for the broad based treatment of infections especially infections of organs such as the skin and vagina
    Patent number: 6420425
    Abstract: A method for treating and preventing infections, bacterial, fungal, insecticidal, parasitic and actinomycotic in origin, especially infections of organs such as the vagina and skin. The methods involves administering to a patient in need thereof a composition comprising a combination of boric acid and acetic acid, in effective amounts. Such a composition is especially useful as a broad based treatment and prevention of vaginal and skin infections of unknown origin and can be used without the need for medical diagnosis or while such a diagnosis is being determined. Such a composition is effective, safe, economical and environmentally friendly, and provides an alternative to existing forms of treatment which are toxic which may cause undesirable side effects.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: July 16, 2002
    Inventor: Steven A. Melman
  • Hair loss prevention
    Patent number: 6420352
    Abstract: Compositions to prevent or reduce hair loss, allowing the body to maintain normal, healthy hair growth, comprising a penetration enhancer together with a testosterone blocker or a vascular enhancer, or both.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: July 16, 2002
    Inventor: W. Roy Knowles
  • Topical delivery systems for active agents
    Patent number: 6419913
    Abstract: This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: July 16, 2002
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Susan M. Niemiec, Jonas C. T. Wang, Stephen J. Wisniewski, Kurt S. Stenn, Gwang Wei Lu
  • &agr;-sulfonylamino hydroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders
    Patent number: 6417229
    Abstract: The present invention relates to a method of using a compound of the formula (I): wherein A, X1, X2 and Q are as defined herein, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof, in the treatment of a disease, condition or disorder of the peripheral or central nervous system, including but not limited to Alzheimer's disease, stroke/cerebral ischemia, head trauma, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, migraine, cerebral amyloid angiopathy, AIDS, age-related cognitive decline, mild cognitive impairment and prion diseases.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: July 9, 2002
    Assignee: Pfizer Inc
    Inventors: Barbara G. Sahagan, Anabella Villalobos
  • Inhibition of novel calcium entry pathway in electrically non-excitable cells acting as an anti-proliferative therapy
    Patent number: 6413967
    Abstract: The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: July 2, 2002
    Assignee: The University of Virginia Patents Foundation
    Inventors: Lloyd S. Gray, Doris M. Haverstick, John J. Densmore, Gabor Szabo
  • Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors
    Patent number: 6413948
    Abstract: The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor for treating a glutamate abnormality and effecting a neuronal activity in an animal.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: July 2, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin