Abstract: A bio-electroceutical device includes: a cell reservoir configured to accommodate a cell cluster comprising an organoid fused with a biomaterial; and a cell controller configured to control, using an electrical signal, a secretion of an active component by the organoid in the cell cluster.

Abstract: A hand-operated flow regulator is adapted to be inserted between an elastomeric bulb pump and a tubing as a part of an enema flow path. The hand-operated flow regulator comprises a main flow body, and a tubular pump coupling end part having a free pump coupling end and defining a first flow section. The tubular pump coupling end part extends via an exterior regulator body part into a tubular tube coupling end part having a free tube coupling end and defining a second flow section. An interior regulator body part is situated rotatable and substantially coaxially inside the exterior regulator body part, and a pivotable grip is in operative communication with the interior regulator body part to open and close the enema flow path.

Abstract: The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto.

Abstract: A syringe assembly includes a syringe and a vibrator configured to vibrate at at least one frequency to reduce stopper friction. The vibrator is attached to the syringe. The syringe assembly may further include an infusion pump configured to draw fluid from the syringe with a negative pressure.

Abstract: The invention is an organizing device that provides a structural frame adapted to receive and house a plurality of medical tubings (e.g., IV tubing). The device includes a central channel that extends from the rear face into an interior of the device. The device also includes a pair of side faces that include a plurality of tubing channels that extend from the first side face through the interior of the device to the second side face. Each tubing channel is in fluid communication and connects with the central channel. The device also includes a plurality of unique indicators, each corresponding to a particular tubing channel for ease of identification.

Abstract: The invention relates to an intravenous catheter apparatus comprising: a catheter hub arranged at a proximal end of a catheter tube, the catheter hub having an inner surface defining a chamber; a needle defining an axial direction and having a needle tip, the needle extending through the chamber and the catheter tube when in a ready position; a needle guard slidably arranged on the needle and at least partially received in the chamber when the needle is in the ready position, the needle guard including a base portion and first and second arms extending from the base portion, wherein the first arm is deflected radially outwards by the needle against a restoring force when the needle is in the ready position whereby the needle guard is brought into retaining contact with the catheter hub; and wherein the catheter apparatus includes a valve which separates a distal space arranged in distal direction from the valve from a proximal space arranged on proximal direction from the valve.

Abstract: A non-electrically driven enteral feeding pump including an expandable elastomeric bladder is provided. The enteral feeding pump includes a fluid delivery tube. The fluid delivery tube controls flow rate of fluid from the pump. The present invention further describes an enteral feeding pump assembly including the portable enteral feeding pump and a peristaltic pump. The peristaltic pump can be configured to be operatively coupled to the elastomeric bladder of the enteral feeding pump for transferring fluid from a reservoir external to the elastomeric bladder into a chamber of the elastomeric bladder.

Abstract: A patient access site securement system includes a housing with an inlet, an outlet and an internal fluid path between the inlet and the outlet. The housing also has a connecting portion that connects to a catheter and/or a fluid line attached to the catheter. A contact surface is located on an underside of the housing and positions the patient access site securement system on the patient. A first reservoir with an interior holds a liquid and transitions from a first state to a second state. The interior is in fluid communication with the inlet when the reservoir is in the second state to allow the liquid to flow from the inlet, through the internal fluid path and exit the outlet. The liquid interacts with the contact surface and/or the patient to alter a level of securement between the catheter and the patient.

Abstract: An infusion pump including a plunger, a proximal valve located proximally to the plunger, a distal valve located distally to the plunger, and a controller configured to trigger the position of the plunger, such that both in its upper position and its lower position, the plunger squeezes a section of an infusion tube, such that opposite sides of an inner surface of the section do not contact one another.

Abstract: A needle shield assembly for use with a needle assembly is disclosed. The needle shield assembly includes an elongate needle shield comprising a shield portion, a hub connection portion and a bridge portion including a living hinge having a thickness. The bridge portion joins the hub connection portion and the shield portion. The hub connection portion includes a partially circular receiving ring having a diameter sized to frictionally receive a flange of a hub of the needle assembly. The shield portion includes two longitudinal walls defining a cavity and a needle assembling receiving cavity between the two longitudinal walls defining a recess. The shield portion is configured to pivot from an open position in which a needle cannula is exposed, to a closed needle protecting position in which a distal end of the needle cannula is within the longitudinal opening of the shield.

Abstract: A drug delivery system includes a drug containing device and a drug delivery device. The drug containing device includes a chamber carrying a fluid drug and an outlet in fluid communication with the chamber. A first closure initially inhibits the fluid drug from exiting the drug containing device via the outlet. The drug delivery device includes a fluid passageway and a stem having an inlet in fluid communication with the fluid passageway. The stem displaces the first closure from the outlet and enters the outlet to provide fluid communication between the chamber and the fluid passageway and thereby facilitates delivery of the fluid drug to the drug delivery device. A second closure is coupled to the stem, and the second closure engages the first body at the outlet when the stem enters the outlet to inhibit the fluid drug from exiting the drug containing device around the stem.

Abstract: A manual intraosseous (IO) device for introducing a bone portal to a predetermined depth relative to a surface of a target bone, and methods for using same. The device is manually actuated and configured to limit the depth of penetration of a bone portal into a bone cortex independently of an applied driving force and independently of subcutaneous tissue thickness surrounding the bone cortex, while providing terminal feedback that the bone portal has been penetrated to the predetermined depth. The device has transfusion facilitating components that remain fixed at the penetration site following penetration of the bone portal to the predetermined depth and releasable components that are separated from the transfusion facilitating components prior to a transfusion operation. The device may also include a stabilizer, or base, that allows a health practitioner to easily locate the insertion site and allows low profile fixation of the IO transfusion component (IO catheter).

Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.

Abstract: An apparatus for a firing mechanism 102 for use in an injection device 100 and comprising: a rear cap 104 having an elongate member 110 extending axially forwards when installed within the injection device; a plunger 106 releasably connected, directly or indirectly, to the elongate member and, upon release of the connection to the elongate member, axially displaceable in a forward direction; and a plunger driver 112 to drive the plunger axially forwards upon release of the connection to the elongate member, wherein the plunger and the rear cap define an axial length of the assembly, which in turn determines a start position of a forward end of the plunger before release of the connection to the elongate member, and wherein, during construction of the assembly, the plunger is releasably connectable, directly or indirectly, to the elongate member at one of a plurality of positions for controlling the axial length of the assembly.

Abstract: A catheter system may include a catheter assembly. The catheter assembly may include the catheter adapter, which may include a distal end, a proximal end, an inner surface forming a lumen, the lumen extending through the distal end and the proximal end, and a side port disposed between the distal end and the proximal end. The catheter assembly may include an annular valve, which may be disposed within the lumen and aligned with the side port. The annular valve may seal a fluid pathway from the side port to the lumen. The catheter assembly may include a retainer ring disposed proximal and/or proximate the annular valve within the lumen. The catheter assembly may include a catheter extending distally from the distal end of the catheter adapter.

Abstract: A device for clearing obstructions from a medical tube includes a housing defining an interior, an exterior, and a port providing fluid communication therebetween. The device further includes an elongated guide wire residing at least partially within the housing, and first and second rollers defining a nip therebetween that are located within the housing. A guide wire extends through the nip and is drivable for advancement and retraction thereof through the port via rotation of the rollers.

Abstract: Described herein is an implantable access port device with a catheter compartment which permits lengthening or shortening the catheter in response to changes in tension of the distal catheter. Implantable access port devices are used extensively in the medical field to facilitate the performance of recurrent therapeutic tasks such as repeated drug delivery, drainage, blood sampling, transfusions, or total parental nutrition. In current access port systems, the catheter is rigidly attached to the access port via a connection ring. As such, the system does not provide any flexibility or ability for catheter length adjustments, which can lead to long-term complications such as dislodgement of catheters, migration of catheters, port separation with extravasation, suture disruption, and mechanical failure of the access port system. These catheter-related complications carry serious risks for the patients.

Abstract: A multi-lumen coupler for fluid transfer with a plurality of attachable members is provided. The multi-lumen coupler allows the attachment and detachment of various members used for fluid transfer to an elongated percutaneous medical article such as a catheter or cannula, during use with a patient.

Abstract: A medical connector for minimizing discomfort to a patient may include a substantially rigid inner body and a flexible outer body having a patient interfacing surface and coupled to at least a portion of the substantially rigid inner body. The patient interfacing surface may include a cushion material. The cushion material may be interposed between the substantially rigid inner body and the patient's skin when the medical connector is attached to the patient.