Abstract: A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20.degree. C. and excipients.
Type:
Grant
Filed:
October 23, 1991
Date of Patent:
December 8, 1992
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Andrew Dennis, Peter Timmins, Kevin Lee
Abstract: Novel aluminum and aluminum-zirconium salts are produced by reacting aluminum or aluminum-zirconium halohydrate with an anionic lipophilic component. These salts are useful in antiperspirant compositions or as rheological additives. Also disclosed is a novel process of producing oil-in-water emulsions whereby the novel aluminum or aluminum-zirconium salt functions as a surfactant upon forming.
Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
Type:
Grant
Filed:
April 23, 1990
Date of Patent:
October 22, 1991
Assignee:
Alza Corporation
Inventors:
Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
Abstract: A heat-hardenable binder mixture based on organic resins comprises an organic resin having primary and/or secondary and, if appropriate, also additional tertiary amino groups and a crosslinking agent based on an organic compound which contains at least 2 .beta.-hydroxyalkyl ester groups. The binder mixture can additionally contain pigments, fillers, crosslinking catalysts, corrosion inhibitors and other paint auxiliaries. The binder mixture is used in a process for preparing coatings by applying a coating agent in the form of a film to a substrate and subsequently hardening the film by stoving.