Patents Examined by Thurman Page
  • Patent number: 7265247
    Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: September 4, 2007
    Assignee: IM&T Research, Inc.
    Inventors: Teruo Umemoto, Yong Xu
  • Patent number: 7244860
    Abstract: Compounds of the formula (I), in which R1 is C1-C4alkyl, C6-C10aryi or C7-C11, aralkyl, R2 is an open-chain or cyclic secondary amino group, and R is a radical of the formula in which R3 is C1-C4alkyl or C1-C4alkoxy, and R4 is H, C1-C4alkyl or C1-C4alkoxy, are ligands for metal complexes as homogeneous hydrogenation catalysts for prochiral organic compounds containing double bonds, by means of which a very high activity and productivity and also enantioselectivity can be achieved
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: July 17, 2007
    Assignee: Umicore AG & Co. KG
    Inventors: Felix Spindler, Matthias Lotz, Marc Thommen
  • Patent number: 7230131
    Abstract: A method for preparing, from at least one hygroscopic substance, mixtures that can be granulated and that have little hygroscopicity. The corresponding mixtures, especially carnitine-magnesium citrate and carnitine-magnesium hydroxycitrate, are produced.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: June 12, 2007
    Assignee: Lonza AG
    Inventors: Martin Fuhrmann, Daniel Pianzola
  • Patent number: 7214813
    Abstract: Cyclic ?-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic ?-aminoacids in high yield and enantioselectivity according to the reaction scheme:
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: May 8, 2007
    Assignee: The Penn State Research Foundation
    Inventors: Xumu Zhang, Wenjun Tang
  • Patent number: 7214830
    Abstract: A description is given of processes for the preparation of mono- and bisacylphosphines and of mono- and bisacylphosphine oxides and mono- and bisacylphosphine sulfides, which comprises first reacting organic P-monohalogenophosphines or P,P-dihalogenophosphines, or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with acid halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphines so obtained with sulfur. It is characteristic, inter alia, that the processes are carried out without isolation of the intermediates.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: May 8, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: David George Leppard, Eugen Eichenberger, René Kaeser, Gebhard Hug, Urs Schwendimann
  • Patent number: 7214836
    Abstract: Methods and kits for decomposing organophosphorus compounds in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly decomposed to non-toxic products. The method comprises combining the organophosphorus compound with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions. In a first preferred embodiment, the metal ion is a lanthanum ion. In a second preferred embodiment, the metal ion is a transition metal.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: May 8, 2007
    Assignee: Queen's University at Kingston
    Inventors: R. Stanley Brown, Alexei A. Neverov, Josephine S. W. Tsang
  • Patent number: 7211683
    Abstract: The invention relates to a process for preparing organosilanes of the general formula 1 R3Si—R?,??(1) in which hydrosilanes of the general formula 2 R3Si—H??(2) are reacted with halohydrocarbons of the general formula 3 R?—X??(3) where R are monovalent C1–C18 hydrocarbon radicals, hydrogen or halogen, R? are monovalent C1–C18 hydrocarbon radicals and X is halogen, in the presence of a free-radical initiator which is selected from alkanes, diazenes and organodisilanes.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: May 1, 2007
    Assignee: Wacker Chemie AG
    Inventors: Ulrich Goetze, Michael Hansel, Edgar Schmidt, Norbert Zeller
  • Patent number: 7208605
    Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: April 24, 2007
    Assignee: University of South Alabama
    Inventor: James Hillard Davis, Jr.
  • Patent number: 7208606
    Abstract: The invention pertains to a hydroformylation process for the conversion of an ethylenically unsaturated compound to an alcohol comprising a first step of reacting at an elevated temperature in a reactor the ethylenically unsaturated compound, carbon monoxide, hydrogen, and a phosphine-containing cobalt hydroformylation catalyst, which are dissolved in a solvent, followed by a second step of separating a mixture comprising the alcohol and heavy ends from a solution comprising the catalyst and the solvent, followed by a third step of recycling the solution to the reactor.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: April 24, 2007
    Assignee: Shell Oil Company
    Inventors: Eit Drent, Jacoba Catherina Lucia Johanna Suykerbuyk
  • Patent number: 7208520
    Abstract: The present invention provides ethyl (?)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent ?3-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: April 24, 2007
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Hidetoshi Isawa, Yukihiko Hotei, Kiyoshi Kasai, Junichi Sonehara, Satoshi Akahane, Hiromu Harada
  • Patent number: 7199260
    Abstract: A method of producing 2-fluorocyclopropane-1-carboxylic acid ester, which comprise by allowing a compound represented by the following formula (1): wherein X represents a chlorine atom, a bromine atom or an iodine atom; and R1 represents an alkyl group having 1 to 8 carbon atoms, an aryl group having 6 to 12 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, or an aralkyl group composed of an aryl group having 6 to 12 carbon atoms and an alkylene group having 1 to 6 carbon atoms; to react with a reducing agent in the presence of a phase transfer catalyst. According to the production method of the present invention, the reaction time of dehalogenation can be greatly shortened.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: April 3, 2007
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Yuichiro Tani, Keiji Nakayama, Kenji Sakuratani, Koji Sato
  • Patent number: 7196227
    Abstract: Disclosed is a process for the recovery of phosphorus and/or iodine containing catalyst components, present as an organophosphorus compound such as trihydrocarbylphosphine compounds and tetrahydrocarbylphosphonium compounds, from a solution of at least one such organophosphorus compound in an organic solvent by the steps comprising (1) converting the organophosphorus compound to an iodide complex of a organophosphonium compound which is insoluble in the organic solvent; and (2) separating the insoluble iodide complex of the organophosphonium compound from the solution. The process also results in the recovery of iodine values present in the solution.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: March 27, 2007
    Assignee: Eastman Chemical Company
    Inventors: Jeffrey Scott Kanel, Stanley John Okrasinski
  • Patent number: 7196097
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloallkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: March 27, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • Patent number: 7196230
    Abstract: A novel organophosphorus composition and synthesis thereof, the composition being characterized by one phosphite moiety, one phosoxophite moiety, and a plurality of sterically bulky substituents. The novel composition finds utility as a ligand in Group VIII transition metal phosoxophite complex catalysts and complex catalyst precursors that are used in carbonylation processes, preferably, hydroformylation processes. Additionally, there is disclosed a novel method of preparing a phosphoromonochloridite composition that finds utility as a precursor to the novel phosoxophite composition.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: March 27, 2007
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Wei-Jun Peng, David Robert Bryant
  • Patent number: 7196221
    Abstract: Ionic compounds having a freezing point of no more than 50° C., formed by the reaction of at least one amine salt of the formula R1R2R3R4N+X? (I) with at least one hydrated salt, which is a chloride, nitrate, sulphate or acetate of Li, Mg, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb, Bi, La or Ce; wherein R1, R2 and R3 are each independently a C1 to C5 alkyl or a C6 to C10 cycloalkyl group, or wherein R2 and R3 taken together represent a C4 to C10 alkylene group, thereby forming with the N atom of formula (I) a 5 to 11 membered heterocyclic ring, and wherein R4 is hydrogen, or phenyl, or C1 to C12 alkyl or cycloalkyl group, optionally substituted with at least one group selected from OH, Cl, Br, F, I, phenyl, NH2, CN, NO2, COOR5, CHO, COR5 and OR5, wherein R5 is a C1 to C10 alkyl or cycloalkyl group, and X? is an anion capable of being complexed by the said hydrated salt.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 27, 2007
    Assignee: Scionix Limited
    Inventors: Andrew P. Abbott, David L. Davies, Glen Capper, Raymond K. Rasheed, Vasuki Tambyrajah
  • Patent number: 7189878
    Abstract: The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: March 13, 2007
    Assignee: Neurotech Co., Ltd.
    Inventors: Byoung-Joo Gwag, Sung-Hwa Yoon, Ho-Sang Moon, Eun-Chan Park, Seok-Joon Won, Young-Ae Lee, Hae-Un Lee
  • Patent number: 7173019
    Abstract: The invention relates to compounds of the following formula (I). In these compounds, R1, R2, R3 and R4 are each independently a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms, or hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, alkyloxycarbonyl, or alkylaminocarbonyl. At least two of R1, R2, R3 and R4 comprise the substituted or unsubstituted cyclitol. The linker can be any one of the following: —(CH2)w—, —(CH2)x—C6H4—(CH2)x—, —(CH2)y—NR5—(CH2)y—, and —(CH2)z—HCR6—(CH2)z—; wherein: w, x, y and z are independently an integer having a value of 0–10; R5 is a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms; and, R6 is —OH, —OSO3Na, —OSO3Na substituted with alkyl, cycloalkyl or aryl, or substituted or unsubstituted alkyl, cycloalkyl or aryl. The compounds can also include substituted or unsubstituted cyclitol carbamides with the linker bond at the carbamide nitrogen.
    Type: Grant
    Filed: July 4, 2002
    Date of Patent: February 6, 2007
    Assignee: The Australian National University
    Inventors: Martin Gerhardt Banwell, Ligong Liu, Christopher Richard Parish, Craig Geoffrey Freeman
  • Patent number: 7166605
    Abstract: Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: January 23, 2007
    Assignee: Nicox, S.A.
    Inventors: Piero Del Soldato, Giancarlo Santus, Ennio Ongini
  • Patent number: 7141703
    Abstract: Improved processes for oxidizing alkylbenzene(s) to produce phenol and ketone product(s) using neutralizing base.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: November 28, 2006
    Assignee: Shell Oil Company
    Inventors: Jiemin Yang, Jesse Raymond Black
  • Patent number: 7074962
    Abstract: This invention relates to apparatus particularly a monolith catalytic reactor in a stirred tank reactor. The stirred tank reactor including the fixed bed catalytic reactor apparatus comprises: an housing having an open top and open bottom portion supportably maintained with said tank, said housing having a substantially outwardly extending, horizontal baffle near its top portion said baffle having a least one perforation in its surface, and said housing having at least one perforation in the wall near its top portion; a fixed bed catalyst system supportably retained within said housing permitting both liquid and gas flow therethrough; and, an agitator shaft terminating in a turbine blade substantially adjacent the perforation in the wall of said housing, said agitator having a passageway including an opening in an upper portion thereof to the interior of an upper part of said tank and terminating in an opening adjacent the turbine blade.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: July 11, 2006
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Reinaldo Mario Machado, James Edward Koniski, Stephen Kohler