Patents Examined by Thurman Wheeler
  • Formulations of a transdermal patch for pain management
    Patent number: 10945967
    Abstract: Various formulations (to be used in the form of a single-segment or multi-segment transdermal patch) of bioactive compounds for pain management are described/disclosed. The multi-segmented transdermal patch can include one or more compatible bioactive compounds in each segment. Furthermore, formulations may include silk fibroin and/or microemulsion/nanoemulsion of bioactive compounds and/or microencapsulation/nanoencapsulation of bioactive compounds.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: March 16, 2021
    Inventor: Jae Wang. Song
  • Photosensitive capsules and cosmetic and pharmaceutical use thereof
    Patent number: 10945963
    Abstract: The invention relates to capsules of core/shell type, the core comprising an active agent; the shell comprising one or more concentric and alternating layers of a first photosensitive anionic amino polymer and of a second cationic polymer. The invention also relates to a cosmetic or pharmaceutical composition comprising such capsules. The invention also relates to a non-therapeutic cosmetic process for treating keratin materials, comprising the application to the keratin materials of a cosmetic composition comprising the said capsules, followed by exposure of the deposit formed on the keratin materials to natural light or to artificial light with a wavelength of between 360 and 600 nm.
    Type: Grant
    Filed: September 27, 2014
    Date of Patent: March 16, 2021
    Assignee: L'OREAL
    Inventors: Andrew Greaves, Gleb Sukhorukov, Qiangying Yi
  • Stable pharmaceutical compositions comprising a pyrimidine-sulfamide
    Patent number: 10946015
    Abstract: The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 16, 2021
    Assignee: ACTELION PHARMACEUTICALS LTD
    Inventors: Charles Tokunbo Adesuyi, Bruce Hamilton Lithgow, Olivier Lambert, Lovelace Holman
  • Method of encapsulating a liquid active
    Patent number: 10940336
    Abstract: A method of encapsulation of an active comprising (a) dispersing an active in an aqueous medium having a pH of less than 6; (b) causing the formation on this dispersed active of a polymer shell, the formation comprising the sequential deposition of a series of polymeric layers, each layer being capable of hydrogen bonding with the preceding layer; to form an aqueous slurry of active-containing capsules; characterised in that one of the first two layers is a polycarboxylic acid and that the first two to four layers taken together exhibit an interfacial compression dilation modulus of greater than 10 mN/m. The method allows the precise tailoring of polymeric shells, allowing capsules walls to be much thinner without a loss of strength. The technique is especially useful for the encapsulation of fragrances and flavours.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 9, 2021
    Assignee: GIVAUDAN SA
    Inventors: Stephane Bone, Cédric Geffroy, Sandrine Le Tirilly, Patrick Perrin, Claire Vautrin, Cècile Monteux, Nadége Pantoustier
  • Method for improving pharmacokinetics
    Patent number: 10918626
    Abstract: The object of the present invention is to inhibit oxidative metabolism of a compound of formula I by co-administration with ritonavir, a cytochrome P450 inhibitor.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: February 16, 2021
    Assignee: Roche Palo Alto LLC
    Inventor: Jonathan Q. Tran
  • Solution for treating contact lens and contact lens packaging system
    Patent number: 10918761
    Abstract: A solution for treating a contact lens and a contact lens packaging system are provided. The solution includes about 0.01 to about 1.0 parts by weight (pbw) of a polymer having phosphorylcholine groups, about 0.005 to about 0.05 pbw of a hydrophilic molecule, about 0.01 to about 1.0 pbw of an inorganic salt, and about 100 pbw of water. A number-average molecular weight of the polymer is about 4,000 to about 1,000,000 daltons. The polymer has a structure of formula (I): wherein, in formula (I), m is a positive integer, n is zero or a positive integer, and R is C2-C12 alkyl group, or C2-C12 hydroxyalkyl group. When n is a positive integer, m/n is greater than 1. Moreover, a number-average molecular weight of the hydrophilic molecule is about 10,000 to about 5,000,000 daltons. The hydrophilic molecule is hyaluronic acid (HA) or hyaluronate salt.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: February 16, 2021
    Assignee: PEGAVISION CORPORATION
    Inventors: Yu-Chin Lai, Min-Tzong Yeh, Han-Yi Chang, Ya-Hui Chang
  • Drug releasing coatings for balloon catheters
    Patent number: 10912932
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 9, 2021
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Cleansing composition
    Patent number: 10912725
    Abstract: A liquid cleansing composition comprising water in an amount sufficient to form a liquid composition, a fatty acid soap, a structuring agent, and talc. The cleansing composition has a creamy texture and provides good skinfeel properties.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: February 9, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Diana Scala, Patricia Hall-Puzio
  • Drug releasing coatings for balloon catheters
    Patent number: 10912931
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 9, 2021
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Antimicrobial agent containing polyalkyleneimine derivative
    Patent number: 10905117
    Abstract: The present invention is an antimicrobial agent containing a polyalkyleneimine derivative formed by adding a substituent group having a structure of a following Formula (1) to a nitrogen atom of polyalkyleneimine. —CH2CH(OH)CH2—O—R1??(1) In the formula, R1 represents an alkyl group with 6 to 20 carbon atoms, an alkenyl group with 6 to 20 carbon atoms, an aryl group with 6 to 20 carbon atoms, or —(CH2CH2O)n—R2. R2 represents an alkyl group with 6 to 20 carbon atoms, an alkenyl group with 6 to 20 carbon atoms, or an aryl group with 6 to 20 carbon atoms. n represents an integer of 1 to 50.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 2, 2021
    Assignee: NIPPON SHOKUBAI CO., LTD
    Inventors: Hiroko Izumi, Masahiro Nakanosho
  • Salts of 3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl) phenoxy]ethyli-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same
    Patent number: 10898461
    Abstract: Described herein are salts of 3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide, in particular that of formula (I): wherein HA is naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, oxalic acid, benzenesulfonic acid, or sulfuric acid, or hydrates thereof, and crystalline forms thereof characterized by the powder X-ray diffraction diagram and the 13C CP/MAS NMR solid state spectrum. Also described are compositions, methods of use and preparation thereof.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: January 26, 2021
    Assignee: Pharmacyclics LLC
    Inventors: Marina Gaillard, Philippe Letellier
  • Polymer coatings containing drug powder of controlled morphology
    Patent number: 10898353
    Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: January 26, 2021
    Assignee: Micell Technologies, Inc.
    Inventors: Charles Douglas Taylor, James B. McClain, Mike Cole, James P. DeYoung, Clint Smoke
  • Therapeutic compositions comprising n-alkyl-hydroxy polymers
    Patent number: 10881682
    Abstract: The disclosure describes methods and therapeutic compositions comprising polymers modified with N-alkyl-hydroxy groups comprising one or more carbon atoms. The compositions are useful for gene delivery, and exhibit broad-spectrum antiviral activity and low toxicity in vitro.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: January 5, 2021
    Assignee: International Business Machines Corporation
    Inventors: James Hedrick, Dylan Boday, Jeannette Garcia, Rudy Wojtecki, Yi Yan Yang, Chuan Yang
  • Cholestyramine granules, oral cholestyramine formulations and use thereof
    Patent number: 10881685
    Abstract: The invention relates to small granules comprising cholestyramine. The granules have a high cholestyramine content and are stable enough to be coated with one or more coating layers. The invention also relates to a multiparticulate drug delivery system comprising such granules. The invention further relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine granules that are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption and bile acid diarrhoea.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: January 5, 2021
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Kurt Lövgren
  • Drug delivery systems comprising solid solutions of weakly basic drugs
    Patent number: 10864166
    Abstract: The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ?g/mL at pH 6.8.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: December 15, 2020
    Assignee: Adare Pharmaceuticals, Inc.
    Inventors: Gopi Venkatesh, Luigi Boltri, Italo Colombo, Jin-Wang Lai, Flavio Fabiani, Luigi Mapelli
  • Oral cholestyramine formulation and use thereof
    Patent number: 10864228
    Abstract: The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a diffusion-controlled inner coating and an enteric outer coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: December 15, 2020
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • Pharmaceutical compositions
    Patent number: 10857171
    Abstract: The stable pharmaceutical compositions comprising a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof are disclosed.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: December 8, 2020
    Assignee: WOCKHARDT LIMITED
    Inventors: Mohammad Ajmal Shareef, Mrutunjaya Sahu, Ajaykumar Handa
  • Aripiprazole prodrug composition
    Patent number: 10849894
    Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: December 1, 2020
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Philip Cresswell, Magali Hickey, Kristopher Perkin, Greg Smith, Elaine Liversidge, Brian Steinberg, David Manser, Tarek Zeidan
  • Liquid precursor compositions and uses thereof for a ph-dependant sustained release treatment of oral disorders
    Patent number: 10843013
    Abstract: The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: November 24, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEWBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Michael Friedman, Doron Steinberg, Irith Gati
  • Drug releasing coatings for medical devices
    Patent number: 10835719
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: November 17, 2020
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang