Patents Examined by Tiffany Gough
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Patent number: 8871458Abstract: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is at increased risk of fatal prostate cancer.Type: GrantFiled: December 22, 2009Date of Patent: October 28, 2014Assignee: Wake Forest University Health SciencesInventors: Gary G. Schwartz, Halcyon G. Skinner
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Patent number: 8802087Abstract: Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic pH range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase. The compositions according to the invention are suitable for treating or inhibiting maldigestion, especially maldigestion due to chronic exocrine pancreatic insufficiency, in mammals and humans.Type: GrantFiled: March 22, 2005Date of Patent: August 12, 2014Assignee: Abbott Products GmbHInventors: George Shlieout, Bernd Boedecker, Siegfried Schaefer, Bernd Thumbeck, Peter-Colin Gregory
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Patent number: 8802386Abstract: A method is provided for determining in real time the course of thrombin activity in a sample of blood or plasma as it appears in and disappears from the simple which comprises adding a thrombin substrate to the sample that, per unit time, produces a detectable signal in a quantity that bears relation to the amount of thrombin present. Simultaneously, in a control sample of the same blood or plasma in which thrombin generation is not triggered, the activity of a standard preparation with invariable thrombin activity is measured. The exact molar amount of thrombin present at any moment is obtained by comparison of the activity measured in clotting blood and the simultaneously measured calibrator. The method is useful inter alia for diagnosing hyper- and hypo-coaguable states, either congenital, acquired or drug-induced in humans and animals. Also provided is a kit for use in this method.Type: GrantFiled: May 1, 2003Date of Patent: August 12, 2014Assignee: Synapse B.V.Inventors: Peter Giesen, Hendrik Hemker, Raed Al Dieri, Suzette L. Beguin, Robert Wagenvoord
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Patent number: 8771980Abstract: Biogas is obtained in a solid-state anaerobic digester from a solid organic biomass and a digestion effluent produced in an associated liquid anaerobic digester. The solid organic biomass and digestion effluent are mixed to produce an effluent-biomass mixture. The effluent-biomass mixture is then incubated in the solid state anaerobic digester, producing a biogas and a digestate. The incubation is controlled by adjusting the composition and properties of the effluent-biomass mixture. The solid organic biomass may comprise lignocellulosic biomass, food waste, agricultural waste and the like.Type: GrantFiled: February 14, 2012Date of Patent: July 8, 2014Assignee: The Ohio State University Research FoundationInventors: Yebo Li, Jiying Zhu, Caixia Wan
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Patent number: 8771677Abstract: The present invention features colony-forming unit cells derived from the chorion of human placenta and describes compositions and methods for the uses of chorionic cells and their products for therapeutic purposes based upon production and release of multiple growth factors and cytokines by these cells stimulating tissue regeneration independent of engraftment, as well as differentiation into a specific cell type.Type: GrantFiled: December 3, 2009Date of Patent: July 8, 2014Inventors: Vladimir B Serikov, Frans A Kuypers
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Patent number: 8765397Abstract: A cell dispersion method, a cell dispersing agent and a cell measurement method, each of which can disperse a cell mass while reducing damage to a cell are provided. Upon dispersing a cell mass, a fluororesin particle is used. A cell mass composed of an aggregated of multiple cells is mixed with a fluororesin particle in a liquid medium, thereby separating the cell mass into individual cells to disperse the cells. In addition, the dispersed cells are measured by flow cytometry, thereby carrying out cell measurement.Type: GrantFiled: July 10, 2009Date of Patent: July 1, 2014Assignee: Sysmex CorporationInventor: Hiroyuki Kabata
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Patent number: 8753668Abstract: Disclosed are methods for producing yeast ?-glucan and mannan preparations. The methods employ an autolysis process, followed by enzymatic treatment with one or more of a protease, glucanase or lipase. The preparations produced may be used in food supplements, pharmaceuticals, cosmetics, animal feeds, and neutraceuticals.Type: GrantFiled: January 25, 2010Date of Patent: June 17, 2014Assignee: Sensient Flavors LLCInventor: Joseph James Sedmak
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Patent number: 8685637Abstract: Described herein are kits for use in cryopreserving mammalian sperm including a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and monothioglycerol.Type: GrantFiled: December 21, 2012Date of Patent: April 1, 2014Assignee: The Jackson LaboratoryInventors: G. Charles Ostermeier, Jane S. Farley, Robert Taft, Michael V. Wiles
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Patent number: 8679803Abstract: The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in terms of total ethanol produced and in terms of the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products (i.e., ethanol). In accordance with this invention bicarbonate ions are used to enhance ethanol fermentation and/or reduce the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products, i.e., ethanol. The present invention can also be used for enhancing fermentation end products in, for example, the fuel ethanol, industrial, cheese, brewing, and wine making industries.Type: GrantFiled: April 28, 2011Date of Patent: March 25, 2014Assignee: Church & Dwight Co., Inc.Inventors: Melvin H. Czechowski, Steven A. Bolkan
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Patent number: 8642012Abstract: The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.Type: GrantFiled: January 7, 2009Date of Patent: February 4, 2014Assignee: Hyperion Therapeutics, Inc.Inventor: Bruce Scharschmidt
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Patent number: 8569018Abstract: The inventive process converts cellulosic biomass into a gel-like state that is readily hydrolyzed by appropriate enzymes. First the biomass is mechanically reduced in size. The biomass is then mixed and kneaded with an aqueous solution of a hydrophilic polymer that acts as a conditioning agent or as a co-solvent. During mixing the cellulose (and hemicellulose) in the biomass swells and becomes hydrated forming a viscous gel-like material. The processed material can then be thinned through the addition of water whereupon hydrolytic enzymes are mixed into the material and rapid hydrolysis into free sugars takes place. Dextrins are effective hydrophilic polymers for conditioning biomass. Polyvinyl alcohol is a particularly effective conditioning agent for use with biomass when converted into a viscous gel by adding borate ions.Type: GrantFiled: March 31, 2009Date of Patent: October 29, 2013Assignee: Biomass Conversions, LLCInventor: Seiji Hata
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Patent number: 8492080Abstract: The disclosure relates to the use of culture media containing thyroid hormones or analogs thereof, and includes methods and uses thereof for embryo culture, embryo production, embryo maturation, improved survival of embryos and improved viability of embryos post cryopreservation.Type: GrantFiled: October 20, 2009Date of Patent: July 23, 2013Assignee: University of GuelphInventors: William Allan King, Fazl A. Ashkar
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Patent number: 8435729Abstract: Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).Type: GrantFiled: June 12, 2007Date of Patent: May 7, 2013Assignee: The Jackson LaboratoryInventors: G. Charles Ostermeier, Jane S. Farley, Robert Taft, Michael V. Wiles
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Patent number: 8420307Abstract: Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).Type: GrantFiled: June 21, 2011Date of Patent: April 16, 2013Assignee: The Jackson LaboratoryInventors: G. Charles Ostermeier, Jane S. Farley, Robert Taft, Michael V. Wiles
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Patent number: 8246951Abstract: The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.Type: GrantFiled: June 3, 2008Date of Patent: August 21, 2012Assignee: 3M Deutschland GmbHInventors: Oliver Kappler, Ingo R. Haeberlein
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Patent number: 8241842Abstract: The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.Type: GrantFiled: December 10, 2004Date of Patent: August 14, 2012Assignee: California Institute of TechnologyInventors: Julian Michael Tyszka, Changjun Yu, Daniel Schwartz, Ilene Sugino, Scott E. Fraser
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Patent number: 8182806Abstract: Synovial villi derived explants and related surgical tools used to repair or prevent damage to injured or diseased tissue, including connective tissue. The tools including a harvesting tool for selectively harvesting synovial villi from the joint of patient and a delivery tool having a bulbous end for delivering the synovial villi derived explants while reducing damage to surrounding tissue.Type: GrantFiled: August 2, 2010Date of Patent: May 22, 2012Inventor: Lanny L. Johnson
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Patent number: 8173388Abstract: The disclosed invention provides a self-contained sterilization indicator for evaluating the effectiveness of a sterilization process. The sterilization indicator includes a cap configured for housing a growth medium, the cap being mountable on a container that contains a concentration of microorganisms. The cap comprises an inner chamber for housing the growth media. The inner chamber has an opening and a breakable barrier overlying the opening for encapsulating the growth media within the inner chamber of the cap. The biological indicator is adapted for breaking the breakable barrier at a selected time to introduce the growth medium into the container such that the growth medium contacts the microorganisms.Type: GrantFiled: September 30, 2008Date of Patent: May 8, 2012Assignee: American Sterilizer CompanyInventors: Mark Edward Pasmore, Phillip P. Franciskovich, Tricia A. Cregger, Alan M. Solomon
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Patent number: 8039228Abstract: Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a microorganism, the enzyme is activated. The zymogens can be used to amplify detection assays.Type: GrantFiled: September 2, 2004Date of Patent: October 18, 2011Assignee: Expressive Constructs, Inc.Inventors: Gerard J. Colpas, Shite Sebastian, Mitchell C. Sanders
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Patent number: 7998700Abstract: Staining mixtures comprising viable spermatozoa, a composition which regulates oxidation/reduction reactions intracellularly or extracellularly, and a DNA selective dye are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduring the various process steps typically associated with the sorting of sperm cells into gender enriched populations, thereby resulting in post-sort compositions with an increased number of viable or motile sperm. Processes for staining sperm cells comprising the formation of a staining mixture are also disclosed.Type: GrantFiled: March 29, 2005Date of Patent: August 16, 2011Assignee: Inguran, LLCInventors: Cindy L. Ludwig, Jeffrey A. Graham, Kathleen S. Crowley, Muhammad Anzar