Abstract: In various embodiments, disclosed herein is an artificial cornea, comprising an optic zone that is similar in thickness to a natural cornea and a peripheral skirt having a thickness less than the thickness of the optic zone, where the surfaces of the optic zone and peripheral skirt comprise one or more microstructures or nanostructures. In various embodiments, further disclosed herein are methods of manufacturing nanostructures on an artificial cornea, as well as treating a disease by providing an artificial cornea having one or more microstructures and/or nanostructures.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
March 29, 2022
Assignee:
The Regents of the University of California
Inventors:
Albert Yee, Marjan Farid, Roger Steinert, Elena Liang, Mary Nora Dickson
Abstract: An IOL utilizes a haptic formed as a toroid portion configured to fit into a capsular bag of an aphakic eye of a patient. The toroid portion may be separate from an IOL optic and may include a receiving feature for the IOL optic. The toroid portion may be configured for intraoperative fluid-filling for snug fitting at the equator of the capsular bag, in order to immobilize the IOL optic.
Abstract: A medical implant including an anchor portion including a plurality of arms adapted to engage an internal tissue wall of a body from two opposite faces, wherein the anchor portion is configured such that at least one of the arms does not have an entirely overlapping arm on the other side of the wall and an opening portion adapted to define an opening for blood flow through the internal tissue wall, when the anchor portion engages the wall.
Type:
Grant
Filed:
July 8, 2019
Date of Patent:
February 22, 2022
Assignee:
V-Wave Ltd.
Inventors:
Tamir Levi, Meir Rosenberg, Ori Ben-Amotz, Yoram Rozy, Eyal Benbenisti, Roey Shafrir, Doron Kopelman, Itshak Cohen, Tamar Harel
Abstract: An eye-implantable electrowetting lens can be operated to control an overall optical power of an eye in which the device is implanted. A lens chamber of the electrowetting lens contains first and second fluids that are immiscible with each other and have different refractive indexes. By applying a voltage to electrodes of the lens, the optical power of the lens can be controlled by affecting the geometry of the interface between the fluids. To prevent fouling the surface due to folding or other manipulation of the lens during the insertion process, one or more surfaces within the lens chamber is highly underwater oleophobic.
Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with fold(s) extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes. A third lens component coupled to the first or second component provides additional optical power.
Abstract: A transcatheter valve assembly replacement device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the annulus when the valve assembly is deployed. An inwardly extending seal is attached to an outer frame. The inwardly extending seal is engaged with prosthetic valve leaflets.
Abstract: The abstract has been amended to the following: “A heart valve replacement device for endovascular repair is provided. The heart valve replacement device includes a plurality of fibers for creating a seal with an anatomy of the patient. A heart valve carried by an inner graft covering. The plurality of fibers form an outer seal for preventing paravalvular leaks between the replacement heart valve and the native valve of a patient.
Abstract: Disclosed is an intraocular lens (IOL) including an anterior surface, a posterior surface and an optical axis. At least one of the anterior or posterior surfaces has a diffractive profile formed thereon. The diffractive profile has diffractive focal points for far vision, intermediate vision, and near vision. The diffractive profile corresponds to a superposition of a first partial diffractive profile and a second partial diffractive profile, the first partial diffractive profile has a focal point of order +n that coincides with the diffractive focal point for intermediate vision or with the diffractive focal point for near vision, the second partial diffractive profile has a focal point of order +n that coincides with the diffractive focal point for far vision and a focal point of higher order than +n that coincides with the diffractive focal point for near vision.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
September 28, 2021
Assignee:
PhysIOL S.A.
Inventors:
Christophe Robert Marie Armand Pagnoulle, Suad Redzovic, Laure Voisin, Damien Gatinel, Jerome Jean D. Loicq
Abstract: An optical device (2300) including a partial or incomplete optic (2320) configured operatively as an add-on (e.g., supplemental lens/optic) for an (existing) optical element or system, the partial or incomplete optic having an active area configured in relation to the optical element or system such that the partial or incomplete optic controls or changes foci of light incident upon or provided to the active area, but does not control or change foci of light bypassing optically relevant portions of the partial or incomplete optic, and associated methods for enhancing vision.
Abstract: An ophthalmic device includes an optic including an optic axis and an open-loop haptic structure coupled with the optic. The open-loop haptic structure includes a pair of open loops, the pair of open loops comprising a first open loop and a second open loop. At least a portion of the first open loop extends in a first angular direction. At least a portion of the second open loop extends in a second angular direction, the second angular direction being opposite the first angular direction.
Type:
Grant
Filed:
September 27, 2018
Date of Patent:
August 31, 2021
Assignee:
Alcon Inc.
Inventors:
Stephen John Collins, Jonathan David McCann, Jian Liu, Michael Lee Mangum
Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets, to inhibit prolapse into the left atrium. At least one marginal chordae is severed, to permit leaflet closure against the band.
Type:
Grant
Filed:
March 1, 2019
Date of Patent:
August 10, 2021
Assignee:
Heart Repair Technologies, Inc.
Inventors:
Valavanur A. Subramanian, Thomas Afzal, Gary Hulme, Jeffrey Christian, Michael L. Reo
Abstract: The present invention includes a device for effecting deformation of a sclera of an eye, including an expandable, mesh tube having holes dispersed through an entire surface thereof and with first and second tapered ends, and inserted unexpanded to deform the sclera when expanded. A central portion is intrascleral, with the first and second tapered ends external to the sclera on top of an intact scleral surface to deform during expansion, and simultaneously causes the sclera to be deformed so that the sclera moves towards the inside of the eye while simultaneously causing the sclera to move towards the outside of the eye. The mesh tube includes struts, connecting points of the struts are of different sizes, the first and second tapered ends and the connecting points within the tapered ends are thicker than the connecting points of the mesh tube, and the mesh tube includes fixation tabs.
Abstract: An ophthalmic apparatus includes a support structure; a substrate included with the support structure; at least one conductor disposed on the substrate; and a hermetic barrier structure disposed over the at least one conductor. The hermetic barrier structure further includes a stack of alternating flexible insulating material and superelastic metal alloy layers.
Abstract: An endovascular heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, an outer frame formed from a metallic material and defining a gridded configuration. A sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The plurality of radially extending fibers include first fibers extending from a first position relative to the outer frame and second fibers extending from a second position relative to the outer frame that is distally spaced-apart from the first position. The gridded configuration includes an uncovered open cell between the first position and the second position. The first fibers and the second fibers are configured to cooperatively form a seal when compressed within the aortic annulus. A length of the first fibers is greater than a height of the uncovered open cell.
Abstract: A stentless support structure capable of being at least partly assembled in situ. The support structure comprises a braided tube that is very flexible and, when elongated, becomes very long and very small in diameter, thereby being capable of placement within a small diameter catheter. The support structure is preferably constructed of one or more thin strands of a super-elastic or shape memory material such as Nitinol. When released from the catheter, the support structure folds itself into a longitudinally compact configuration. The support structure thus gains significant strength as the number of folds increase. This radial strength obviates the need for a support stent. The support structure may include attachment points for a prosthetic valve.
Type:
Grant
Filed:
August 27, 2018
Date of Patent:
June 8, 2021
Assignee:
HLT, Inc.
Inventors:
Gary A. Thill, Robert Foster Wilson, John P. Gainor, Christopher M. Banick
Abstract: An endovascularly deployed prosthetic includes a portion for being positioned within an ascending aorta. The prosthesis includes a replacement aortic valve on a proximal end thereof. The prosthesis includes an increased diameter portion that seals against the aorta at a more distal portion, and a pair of conduits extend from the increased diameter portion to the coronaries for fluidly coupling the coronaries to the prosthesis.
Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.
Type:
Grant
Filed:
March 22, 2019
Date of Patent:
May 25, 2021
Assignee:
Heart Repair Technologies, Inc.
Inventors:
Valavanur A. Subramanian, Thomas Afzal, Gary Hulme, Jeffrey Christian, Michael L. Reo
Abstract: A transcatheter aortic valve replacement (TAVR) device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the aortic annulus when the TAVR is deployed.
Abstract: Knowledge of the anatomical, post-operative position and orientation influences not only the selection of the IOL to be implanted but also the result of the refractive operation on the eye. In the method for selecting an IOL to be implanted into an eye on the basis of the prediction of the anatomical, post-operative position (ALP) and orientation thereof, based on pre-operative measuring values such as, for example, anterior chamber depth (VKT), lens thickness (LD) and axial eye length (AL), the invention additionally or exclusively uses the curvature(s) of the eye lens or measuring values derived therefrom. The proposed method is used to predict the anatomical, post-operative position (ALP) and orientation of an intraocular lens (IOL) to be implanted into an eye.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
April 27, 2021
Assignee:
Carl Zeiss Meditec AG
Inventors:
Oliver Findl, Michael Trost, Nino Hirnschall, Martin Volkwardt, Ferid Bajramovic, Tanja Teuber