Abstract: A method of forming a scaffold is disclosed herein. In some embodiments, a method of forming a scaffold includes dissolving a polymer in a solvent to form a polymer solution; adding additive precipitating agent to the polymer solution; precipitating and expanding the polymer from the polymer solution to form a scaffold; and removing the solvent from the scaffold. In some embodiments, prior to adding the precipitating agent, the method further comprising adding at least one of calcium phosphate or a bioactive additive to the polymer solution to form a mixture including the polymer solution and the at least one of calcium phosphate or bioactive additive.

Abstract: Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.

Abstract: A water-in-oil emulsion cosmetic, has good stability and does not cause a decrease in viscosity when a large quantity of fragrance material is blended. The water-in-oil emulsion cosmetic, includes: (a) 5 to 15% by mass of a fragrance material, (b) 1.5 to 3% by mass of dimethyldistearylammonium hectorite, and, (c) a nonionic surfactant, wherein, the (c) nonionic surfactant comprises (c1) 2 to 10% by mass relative to the total weight of the composition of a polyether modified silicone having a C12-22 branched hydrocarbon chain, and may comprise (c2) 10% by mass or less relative to the total weight of the composition of a polyether modified silicone having no alkyl chain, wherein, a ratio of the total blending quantity of the component (c1) and the component (c2) relative to a blending quantity of the component (b) is 2 or more, a ratio of the total blending quantity of the component (c1) and the component (c2) to a blending quantity of the component (a) is 0.

Abstract: The present invention discloses elastic macro porous scaffold and a process for the preparation thereof. The present invention also provides a process for the preparation of macroporous, elastic nano particulate scaffolds comprising of coated or grafted cross linkable nanoparticles, and a crosslinker prepared by crosslinking during ice templating, wherein the modulus increases linearly with temperature.

Abstract: A method enables photoplethysmograph measurement of volume status. The method includes the steps of converting photoplethysmograph voltages to volume measurements and characterizing a local microcirculation as a microcosm in a manner allowing a photoplethysmograph to facilitate noninvasive monitoring of systemic status.

Abstract: An orally disintegrating dosage form of a proton pump inhibitor, methods for its production and use thereof are provided. The dosage form includes a plurality of pellets containing a proton pump inhibitor admixed with a disintegrant to afford rapid disintegration in the oral cavity after administration.

Abstract: Cosmetic composition comprising a combination of surfactants of carboxylate, acylisethionate and alkyl(poly)glycoside type The invention relates to a cosmetic composition comprising: one or more anionic surfactants of carboxylate type, chosen from the compounds of formule (I), R—(OCH2CH2)nW—(CHY1)p-COOX (I), in a content of greater than or equal to 3% by weight relative to the total weight of the composition, one or more anionic surfactants of (C8-C22) acylisethionate type, and -one or more nonionic surfactants of alkyl(poly)glycoside type. This composition is intended for the cosmetic treatment of keratin materials, and in particular for washing the hair. It has excellent foaming power.

Abstract: The invention relates to a cosmetic composition comprising: —one or more anionic surfactants of carboxylate type, chosen from the compounds of formula (I), in a content of greater than or equal to 3% by weight relative to the total weight of the composition, and—one or more anionic surfactants of (C8-C22) acylisethionate type, in a content ranging from 2.5% to 8% by weight relative to the total weight of the composition. This composition is intended for the cosmetic treatment of keratin materials, and in particular for washing the hair. It has excellent foaming power.

Abstract: In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released immediately following administration and again at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released before sleep and whilst a subject is sleeping. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for an immediate, followed by a delayed release of drug.

Abstract: Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.

Abstract: Devices, systems, and methods for applying a bioactive coating to an exterior surface of an implant are disclosed. In some embodiments, the bioactive coating may be applied to the surfaces of the implant within the operating room at the time of implantation. In one embodiment, the implant may be a temporary spacer used to temporary replace an implant in a patient suffering from an infection. The temporary spacer being, for example, an antibacterial material for fighting the infection. In some embodiments, the method includes providing a mold of the implant, and providing the bioactive coating within the mold. The method may further include inserting the implant into the mold so that the exterior surface of the implant contacts the bioactive coating, and then removing the implant from the mold.

Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.

Abstract: A Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3 and a process for its preparation. The polymorphic mixture of Rifaximin is for use as a medicament, in particular in the treatment of traveler's diarrhea and hepatic encephalopathy. A pharmaceutical composition comprises the polymorphic mixture of Rifaximin as active ingredient, in particular, a solid formulation, more in particular, a film coated tablet. A polymorphic form of crude wet rifaximin and of purified wet rifaximin their use are used as intermediates in a process for the preparation of Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3.

Abstract: One embodiment of a contact lens includes a lens body configured to fit directly on the surface of the eye and legible characters positioned on the lens body. Another embodiment of a contact lens comprises a lens body including polymeric material and a lens enhancing material (e.g., ink, silicone material, medicament material, and the like) encapsulated in the polymeric material. The lens enhancing material can be in the form of isolated sections distributed in the surrounding polymeric material. Methods of making contact lenses include forming a first lens layer including a first surface, forming a pattern on the first surface, and forming a second lens layer over the pattern.

Abstract: A resorbable device for the reconstruction of cartilage includes a piece of fabric made of PGA, which can be impregnated with patient blood and fixable to a bone at an articulation, the piece preferably being impregnated with collagen.

Abstract: A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.

Abstract: Confectionary shaped and configured to resemble jewels are provided with various color tints and flavor enhancements. The confectionary are further enhanced by fabrication which includes formulations effective in improving the user's breath and oral hygiene. Novel packaging for supporting and presenting the confectionary resembling jewels are also provided. A dispensing wand receives and supports a plurality of confectionary resembling jewels and is operable to sequentially dispense the confectionary resembling jewels.

Abstract: The invention provides nanoparticle-stabilized nanocapsules, and methods of their preparation and use in delivery of therapeutics, such as nucleic acids. Various embodiments disclosed relate to a nanoparticle-stabilized nanocapsule. Various embodiments disclosed relate to nanoparticle-stabilized nanocapsules for nucleic acid delivery into cells. Various embodiments provide methods of using the nanocapsule for in vivo delivery of the nucleic acid materials.

Abstract: The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.