Abstract: A microfluidic device for obtaining a homogenous plasma-reagent mixture includes a collection module for blood plasma arranged to passively separate the blood plasma from a drop of blood taken, a capillary channel in fluidic connection with said collection module and a storage reservoir for a reagent in fluidic connection with said capillary channel. The device also contains a mixing chamber in fluidic connection with said capillary channel equipped with a flow outlet. The volume of said storage reservoir for reagent being greater than the sum of the volumes of said capillary channel and of said mixing chamber, setting the reagent in motion, after saturation of said capillary channel with blood plasma, induces a flow of the homogenous plasma-reagent mixture from the flow outlet.

Abstract: A sample analysis substrate in which transfer of a liquid is effected through rotational motions, including: a substrate having a rotation axis; a first retention chamber being located in the substrate and retaining a diluent; a measurement chamber being located in the substrate; at least one reagent; a reagent chamber being located in the substrate and having the at least one reagent disposed therein, the reagent chamber being connected to the measurement chamber; and a first diluent path being located in the substrate, and connecting the first retention chamber and the measurement chamber or reagent chamber.

Abstract: Integrated cartridges for sample homogenization, nucleic acid fragmentation, and nucleic acid detection are disclosed herein. The integrated cartridges include a main housing having a sample well and a detection chamber and a sonication feature coupled to and extending outwardly from the main housing. The sonication feature includes a sonication chamber for receiving a sample fluid. A fluidic path directs the sample fluid from the sample well, to the sonication chamber, and to the detection chamber. Systems for use with the integrated cartridges can include sonotrodes with openings for positioning the sonication feature and/or temperature sensors for monitoring the temperature of the sonication feature. Methods include moving the sample fluid from the sample well to the sonication feature, transmitting ultrasonic energy into the sample fluid, moving the sample fluid from the sonication feature to the detection chamber, and performing a nucleic acid detection assay within the detection chamber.

Abstract: The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.

Abstract: A method for preparing one or more biopsy tissue samples for histological examination includes positioning a tissue sample in a tissue cassette, closing a peripheral portion of a frame including a cassette lid, and moving the lid and the tissue cassette from a first position to a second position. The tissue cassette is coupled to a frame by a frame-cassette connector and moving the lid and the tissue cassette from the first position to the second position includes breaking the frame-cassette connector. The tissue cassette has a recess including at least one side wall and a bottom wall and is formed of a first material that can be successfully sectioned in a microtome. In the second position, the bottom wall and at least a portion of the side wall extend downwardly beyond a bottom edge of the frame for sectioning in the microtome.

Abstract: A test sample handling system for transporting test samples to a testing mechanism comprises a rotary sample holder including a carrier cylinder configured to rotate about a central rotational axis thereof and a carrier arm adjustable between a retracted position and an extended position. A carrier is configured to support one of the test samples and is removably coupled to the carrier cylinder. A lifter mechanism is adjustable between a lowered position and a raised position with the adjustment of the carrier arm from the retracted position to the extended position including a decoupling of the carrier from the carrier cylinder and a transporting of the carrier and the corresponding one of the samples to a position above the lifter mechanism. An adjustment of the lifter mechanism from the lowered position to the raised position includes a removal of the one of the samples from being supported by the carrier.

Abstract: A method of acquiring a sample for evaluation of a SiC single crystal, comprising: a step of cutting a SiC ingot in a radial direction at a thickness position, which is located in a range from a curved surface which forms a distal end surface in a crystal growth direction to a seed crystal, to obtain a head member which includes the curved surface, wherein the SiC ingot used in the step is a SiC ingot in which SiC thereof is crystal-grown from a seed crystal along a c axis direction; and a step of polishing a silicon surface of the head member to obtain a sample for evaluation.

Abstract: A specimen collection, storage, transport, and testing device (1) can include an outer vessel (2) containing an internal cup (5) having an openable drain (23) having a brim (22) raised above the bottom floor (27) of the cup. Once opened the drain allows a portion of liquid specimen to flow from the cup into a lower chamber (55) of the vessel and onto a cartridge (3) containing a number of chromatographic assay strips. A lid (4) sealing the vessel can include a downwardly projecting guide tube (35) having first barrier (39) sealing a bottom aperture (38). An oblong initiator (6) can axially engage the guide tube, break the first barrier and open the drain to initiate the test while retaining a pool of liquid specimen in the cup for subsequent confirmatory testing.

Abstract: In one aspect of the present disclosure is a method of contactlessly urging, directly, or moving a substance on the surface of a substrate, the method employing a gas knife (300) configured to produce a gas curtain having parallelogram flow.

Abstract: A reagent pack includes a first reservoir having a continuous rigid wall defining a constant inner space that opens to the ambient environment. An air-tight second reservoir has a flexible wall that defines a variable inner space with one or more second openings. The second reservoir is arranged within the first reservoir and stores fluid reagent. A closure element completely fills the first opening of the first reservoir and includes a first fluid passage fluidly connecting the inner space of the first reservoir, as the waste reservoir, to receive waste liquid. Second fluid passages fluidly connect the second openings of said second reservoirs with respective reagent inlets to supply fluid reagent to the sample analyzer. The inner space of the first reservoir further includes an air passage to allow gaseous communication with the ambient environment to maintain a controlled pressure within said inner space while receiving waste liquid.

Abstract: Disclosed herein are devices for molecule detection and methods for using detection devices for molecule detection, such as nucleic acid sequencing. In some embodiments, a detection device comprises one or more pole pieces, one or more sensors, each of the one or more sensors coupled to at least one of the one or more pole pieces, and detection circuitry coupled to the one or more sensors. The detection circuitry is configured to detect a characteristic of each of the one or more sensors, the characteristic indicating presence or absence of one or more magnetic nanoparticles (MNPs) coupled to at least one of a plurality of molecules to be detected, and at least one of the one or more pole pieces is operable to draw the one or more MNPs toward at least one of the one or more sensors.

Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.

Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.

Abstract: It is an object to provide a cover slip sticking device capable of improving matching between types of clearing agents and cover slips. As a means for solving the problem, a cover slip sticking device includes a dipping bath (21) in which slide glasses (22) on which specimens are attached are housed to be dipped in a clearing agent, a holder (11) having a cover slip (10) and cover slip information (14), a mounting part (C) on which the holder is mounted, a sticking part (B) sticking the cover slip (10) taken out from the holder (11) on the slide glass (22), a reading unit (62) reading the cover slip information (14), a storage unit (65) storing a type of the clearing agent and matching information between types of clearing agents and types of cover slips and a determination unit (66) comparing the cover slip information (14) read by the reading unit (62) and the type of the clearing agent stored in the storage unit (65) with the matching information to determine whether the types match with each other or not.

Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.

Abstract: A workspace isolated from an exterior space by a partition, a glove provided to the partition so that an external surface thereof is exposed to the workspace and an internal surface thereof communicates with the exterior space, and a robot configured to insert an arm into the glove and perform a work in the workspace. The glove includes, at a tip-end part thereof, an operating part provided inside the glove, and a hand part provided so as to be exposed to the workspace.

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

Abstract: An analysis device that includes a placement section, a pressing member, and a measurement member, has an analysis kit including a chip provided with a capillary through which a sample flows and a cartridge superimposed on the chip, and in which a liquid reservoir placed therein to enable a component present in sample can be measured in a state in which the chip and the cartridge have been fitted together. The analysis kit is placed on the placement section. The pressing member presses the analysis kit in a direction in which the cartridge is superimposed on the chip to sandwich the analysis kit between the pressing member and the placement section, and to fit the chip and the cartridge together. The measurement member that measures the component present in the sample in the analysis kit in which the chip and the cartridge have been fitted together.

Abstract: Provided is a packaging container including a bag main body portion having a first surface, a second surface and an opening portion; and a tongue piece portion formed to be continuously extended from the first surface. The bag main body portion and the tongue piece portion have an aluminum vapor-deposited layer on an outside thereof, the packaging container further includes an adhesion portion which is provided on the second surface to be spaced from the opening portion; and a folded-back portion which is provided between the adhesion portion and the opening portion to fold back the tongue piece portion to the opening portion side. A length of the tongue piece portion is a, a length from the opening portion to the folded-back portion is b, and a length from the folded-back portion to the adhesion portion is c. And, a<b+c.

Abstract: Non-enzymatic method and milling device for preparing therapeutic cells from adipose tissue comprising: continuously feeding the adipose tissue to the milling device (2); mechanically separating the cells or cell aggregates from adipose tissue moving through the milling device (2) by means of a multiplicity of blades (19) of a rotor (10), wherein the blades (19) are arranged in a spaced arrangement with respect to the overall direction of flow and the blades (19) are moving about an axis of rotation (18), wherein the axis of rotation (18) is provided essentially parallel to said overall direction of flow; continuously withdrawing the processed tissue comprising the separated cells from the milling device (2).