Abstract: The present invention discloses stable vitamin C concentrates suitable for use in a multichamber dispenser. The compositions have a pH above about 5 and preferably should contain a xanthan and/or a carbomer as a viscosifier.

Abstract: Disclosed is a controlled release tacrine dosage form, which comprises: (a) a core; (b) an inner active layer comprising tacrine and a binder; (c) a release-controlling layer comprising one or more release-controlling-film-forming polymer; and (d) an active overcoat comprising tacrine and a binder. Also disclosed is a process for preparing the controlled release dosage form.

Abstract: The present invention relates to a foamable aerosol concentrate composition, a foamable aerosol agricultural-chemical composition, and a method of controlling diseases and insect pests; particularly, relates to a foamable aerosol concentrate composition suitable for horticulure as a pastime in which an active ingredient of agricultural-chemicals having insecticidal and/or fungicidal activities and also having systemic action through a plant body and a surfactant are dissolved in glycols that are liquid at normal temperature, a foamable aerosol agricultural-chemical composition including the concentrate composition and a propellant both of which are filled in an aerosol container, a method of controlling diseases and insect pests through spraying application of the foamable aerosol agricultural-chemical composition to stems and/or branches of plants to be treated.

Abstract: An amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability can be formed by subjecting a mixture containing efonidipine hydrochloride of the formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140° C. or mechanochemical treatment at from 0 to 140° C., and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vapor-containing gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140° C. and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required.

Abstract: The present invention provides a microstructured cosmetic composition comprising:A) a cosmetically acceptable oil phase which is dispersed in;B) an aqueous phase comprising 0.05 to 3.0, preferably 0.2 to 1.0% by weight, based on the weight of the total composition, of a .beta.-1,3-glucan having a mean molecular weight within the range of from 1.times.10.sup.6 to 12.times.10.sup.6, preferably from 2.times.10.sup.6 to 10.times.10.sup.6 ;the oil phase A) in the microstructured cosmetic composition having a mean particle size within the range of from 0.05 to 1000 microns.

Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

Abstract: A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Abstract: An antirheumatic agent comprising diethyl L-lysylcromoglycate of the following formula ##STR1## or a nontoxic salt thereof as an active ingredient. This compound has an anti-inflammatory action and immunomodulating action, is absorbed by oral administration to be delivered efficiently to local sites, and is associated with fewer side effects, so that it serves well as an antirheumatic agent that can be administered orally.

Abstract: The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store a solid composition including the active ingredient; an actuator arranged within the housing to move the solid composition from the reservoir to a transit area, wherein the solid composition exits the housing at the transit area; a controller that acts on the actuator to adjust movement of the solid composition out of the housing according to the adjustable delivery profile; and a power source arranged to provide energy to the actuator and the controller. The solid composition can be an elongate, solid composition comprising a drug, and up to 90% of a carrier, wherein the composition has a cross-section of less than 0.

Abstract: Novel phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity as well as anti-viral activity. These novel compounds can be incorporated within contraceptive compositions to provide for spermicidal or sperm-immobilizing activity.

Abstract: Cosmetic or dermatological shower preparations, characterized by(a) a content of at most 55% by weight, based on the total weight of the preparations, of one or more surfactants selected from the group consisting of trialkyl- and/or trialkanolamine salts of fatty alcohol sulphates and fatty alcohol ether sulphates and(b) a content of from 30 to 45% by weight, based on the total weight of the preparations, of one or more oil components selected from the group consisting of lipids, which contain from one to three acyl radicals, which have been esterified using an alcohol,(c) a water content of at most 3.5% by weight, based on the total weight of the preparation,(d) optionally containing one or more emulsifiers,(e) optionally containing further surfactants, and(f) optionally containing further cosmetic or pharmaceutical auxiliaries, additives and/or active substances.

Abstract: A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.

Abstract: A wet tissue prepared by impregnating a main body of paper-made tissue with a dilute aqueous solution of epigallocatechin gallate and introducing the impregnated main body into a waterproof container provided with a takeout hole. The tissue is withdrawn and cut through the hole and put to use.

Abstract: A suspension of microcapsules in an organic liquid, the microcapsules containing an aqueous phase, is produced by interfacial polymerization in the presence of a proton transfer catalyst of a water-in-oil emulsion in which the aqueous phase contains a urea/formaldehyde or melamine/formaldehyde prepolymer.

Abstract: Compositions that express a pressure of carbon dioxide are beneficial when used for the care of wounds, and when externally applied to skin damaged by cuts, burns, abrasions, excessive radiation, or from rashes and similar dysfunctions.

Abstract: The present invention relates to a composition, and a method for preventing or reducing contact dermatitis. The composition contains a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material.The present invention is further a dermatologically-compatible barrier film for preventing and reducing contact dermatitis which contains a polysaccharide; a low molecular weight, synergistic saccharide; and optionally one or more additives. The dermatologically-compatible barrier film is formed of a composition containing a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material. The composition is a skin care product in a form of a lotion, a gel or a cream that is applied to skin of mammals.

Abstract: A method for preparing .beta.-sitosterol is disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.

Abstract: The invention provides a cosmetic hair conditioning composition comprising: (a) an effective amount of a film forming polymer; and (b) a cosmetically acceptable vehicle, in which the composition is in the form of a solid. A cosmetic hair conditioning device and methods of conditioning and styling hair are also provided.

Abstract: A solid pharmaceutical composition for oral administration comprising a histamine H.sub.2 -receptor antagonist, a low neutralizing capacity antacid, and a high neutralizing capacity antacid coated with a pH-independent and water-insoluble polymer base, which composition improves the condition of a patient promptly after administration and sustains the effects for an extended period of time in the treatment of digestive disorders on which suppression of gastric acid secretion is effective.

Abstract: The present invention is directed to a tablet, particularly a pharmaceutical dosage form, which contains an encapsulating agent comprising a modified starch which is prepared by enzymatic hydrolysis of a starch molecule after the preparation of a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group, particularly octenyl succinic anhydride starch hydrolyzed by .beta.-amylase or glucoamylase. Such starch allows for good compressibility and hardness of a pharmaceutical dosage form. In addition, the starch may consistently allow for high load and retention of a variety of active agents as well as oxidative resistance.