Abstract: A method and apparatus for the treatment of a particular volume of material, plant or animal tissue including the steps of treating the material plant or animal tissue with at least one photo-active agent, wherein the particular volume of the material, plant or animal tissue retains at least a portion of the at least one photo-active agent, and then treating the particular volume of the material plant or animal tissue with light sufficient to promote a multi-photon excitation of at least one of the at least one photo-active agent retained in the particular volume of the material, plant or animal tissue, wherein the at least one photo-active agent becomes active in the particular volume of the material, plant or animal tissue.

Abstract: A device and method for treating pathological narrowing of fluid-carrying conduits of the human body (such as blood vessels) in an area of a bifurcation is disclosed. In particular, a stent delivery system configured to carry one or more of a pair of dissimilar stents. At least one of the stents is particularly suited for treating a widened portion of a blood vessel immediately proximal to a bifurcation. The stent delivery system can also include a handpiece adapted to selectively deliver the stents.

Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.

Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

Abstract: Systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed.

Abstract: A device and method for treating pathological narrowing of fluid-carrying conduits of the human body (such as blood vessels) in an area of a bifurcation is disclosed. In particular, a stent system comprising a pair of dissimilar stents, one of which is particularly suited for treating a widened portion of a blood vessel immediately proximal to a bifurcation. A stent delivery system including a handpiece adapted to selectively deliver the stents is also disclosed.

Abstract: An intervertebral implant for fusing vertebrae is disclosed. The implant has a body with curved, substantially parallel posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting upper and lower vertebral endplates, and at least one depression at a first end for engagement by an insertion tool. The arcuate implant configuration facilitates insertion of the implant from a transforaminal approach into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit. An implantation kit and method are also disclosed.

Abstract: This invention relates to a trackable medical tool for use in image guided surgery in which the drive shaft rotates about the tracking post.

Abstract: An intervertebral implant for fusing vertebrae is disclosed. The implant has a body with curved, substantially parallel posterior and anterior faces separated by, two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool, at least two vertical through-channels extending through the implant, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and a beveled edge along a perimeter of the superior and inferior faces. The implant configuration facilitates transforaminal insertion of the implant into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies forming a single unit. An implantation kit and method are also disclosed.

Abstract: An endovascular graft, having both an expandable stent portion and a stent cover portion positioned, the graft itself and/or a stent cover-portion coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft prevents endoleaking by promoting a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups.

Abstract: Reinforcement of annulus fibrosis tissue within an intervertebral disc can be achieved through implantation of a support member also functioning as a barrier to resist damage to the tissue or herniation of tissue outside of the disc. The device may be anchored to the surrounding tissue. The device is compressible and may be delivered in a minimally invasive manner through a cannula.

Abstract: The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.

Abstract: A locking device is provided for securing a rod in a receiving part, in particular a polyaxial bone screw. The locking device has a sleeve-type element with a cylindrical outer face and is dimensioned such that the element is displaceable between the legs of the receiving part. The element has an inner thread for receiving an inner screw. An outer nut can be screwed on to an outer thread of the legs to fix the element. The element acts on a pressure element provided in the receiving part to fix the position of the head of the polyaxial bone screw and the inner screw acts on the rod to fix it. The element is preferably provided with slits. During screwing in of the inner screw, the element splays out against the outer nut and thus effectively prevents loosening or detaching.

Abstract: An intervertebral implant, alone and in combination with an insertion tool for inserting same and a method for inserting same. The implant has upper and lower parts which have universal movement relative to each other. Each of the upper and lower parts also has a surface engaging an adjacent vertebrae. Each part has a keel extending from said surface into a cutout in the adjacent vertebrae, and each keel has an anterior opening recess therein. An insert tool has a pair of arms which are received in the recess of the keels through the anterior opening to securely hold and insert the implant. Projections and matching indentations in each arm and the base of its recess securely attached each arm within its keel.

Abstract: A device and method for installing an anchor in a bone of a patient which employs an anchor body having expandable side walls in a tapered shape with retention members on their external surfaces, and an expansion member within the anchor body which is pulled to an engaged position. While in the engaged position the expansion member presses on the inside of the side walls to expand them outwardly to engage the retention members with the bone walls. The side walls have containment ring sections at their distal ends for retaining the expansion member inside the anchor body. The expansion member may be formed as a conical plug with a central aperture and tab recesses on its underside for insertion of an elongated scissors-type instrument with movable prongs that engage into the tab recesses of the expansion plug.

Abstract: Systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Methods of repairing a herniated disc by displacing at least a portion of the herniated segment to within the pre-herniated borders of the disc and anchoring at least a portion of the displaced herniated segment to a site within the disc are also provided.

Abstract: An intervertebral implant for contact with adjacent vertebral bodies is provided. The implant includes a first carrier plate including a front edge, a middle, a rear edge, and a concave, crowned joint surface comprising a lowest point. The implant further includes a second carrier plate including a front edge, a middle, a rear edge, a center line extending between said front edge and said rear edge, and a convex, crowned joint surface comprising a highest point. The joint surfaces are positioned flatly in contact with one another and are configured to support the carrier plates pivotably with respect to one another. The highest and lowest points of the joint surfaces are positioned between the rear edges and the middles of the carrier plates. The convex joint surface projects farther away from the second carrier plate at its end facing the rear edge than at its end facing the front edge.

Abstract: A graft ligament for cross-pinning in a bone tunnel, the ligament comprising a tendon having first, second and third portions in series along the length thereof. The first and third portions are provided with cross-sectional thicknesses less than the cross-sectional thickness of the second portion. The tendon first and third portions are folded over and attached to the second portion to provide a graft ligament having a substantially uniform thickness along the length thereof.

Abstract: A flexible prosthetic tissue-type heart valve having commissures that are substantially decoupled from a cusp support structure. The valve includes three leaflets having arcuate cusp edges and opposed concave shaped free edges, with outwardly-directed attachment tabs therebetween. A cusp support structure in either one or more pieces attaches to the leaflet cusp edges. Three commissures are each formed partly with an axially-extending insert member to which two adjacent leaflet tabs attach. An inverted V-shaped clip maintains close contact between the adjacent leaflet tabs and provides a stress-relieving clamping action in conjunction with the insert member. The insert member attaches about its lower end to base sections of the cusp support structure, or to an intermediate sewing ring, so that the commissures may pivot about the cusp support structure.

Abstract: An apparatus for automatically fixing sutures used in the surgical replacement of a heart valve, includes a first cylinder having a first end and a second end and an interior surface and an exterior surface. An annular lip is formed on the exterior surface adjacent to the second end of the first cylinder. The apparatus further includes a second cylinder having second securing means formed on an interior surface of the second cylinder, such that the second securing means corresponds to and are adapted to fixedly engage the first securing means.