Patents Examined by Tonya Wright
  • Oxadiazole derivatives having anticancer effects
    Patent number: 6720343
    Abstract: A pharmaceutical composition for treating or preventing cancer containing a compound of the general formula (I), a prodrug, a pharmaceutically acceptable salt, or a solvate thereof as an active ingredient: wherein R1 is hydroxy or the like; R2 is optionally substituted lower alkyl or the like; R3 is hydrogen or the like; R4 is optionally substituted arylene or the like; R5 is optionally substituted aryl or the like.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 13, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Takayuki Yoshioka, Ryuji Maekawa, Fumihiko Watanabe
  • Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
    Patent number: 6656940
    Abstract: The present invention relates to tricyclic quinoxaline compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein tyrosine kinases and therefore should be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: December 2, 2003
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Li Sun, Gerald McMahon
  • Preparation of sulfo-N-hydroxy succinimide salts
    Patent number: 6407263
    Abstract: The salt of a sulfonated succinic acid is cyclized, then converted to novel sulfonated hydroxamic acids by reaction with hydroxylamine (which is added or formed in situ), and the novel hydroxamic acid is then cyclized to the sulfo-N-hydroxysuccinimide salt. This synthetic procedure is simple, direct, and more rapid than present procedures for synthesis of the succinimide. Novel sulfo-hydroxamic acid intermediates are formed during this procedure.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: June 18, 2002
    Assignee: Pierce Chemical Company
    Inventors: Marty Carey Wilkes, Martin Lee Bremmer