Patents Examined by Trent Clarke
  • Patent number: 10139418
    Abstract: The present invention relates to a process for the prediction of cell culture performance data of sample cells, a process for the isolation of said cells and a device for the prediction of cell culture performance data of sample cells.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: November 27, 2018
    Inventors: Dietmar Lang, Elaine B. Martin, Gary A. Montague, Christopher J. O'Malley, Tracy S. Root, Carol M. Trim, Jane F. Povey, Christopher M. Smales, Andrew J. Racher
  • Patent number: 9957481
    Abstract: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: May 1, 2018
    Assignee: Academia Sinica
    Inventors: Keng-Hui Lin, Narayan Mishra, Yen-Liang Liu, Chen-Chie Wang
  • Patent number: 9878046
    Abstract: Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: January 30, 2018
    Assignee: Halozyme, Inc.
    Inventors: Harold Michael Shepard, Curtis Thompson, Xiaoming Li, Gregory I. Frost
  • Patent number: 9845318
    Abstract: 2,5-Bis(benzoxazol-2?-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 19, 2017
    Assignee: The University of Akron
    Inventors: Yi Pang, Yongqian Xu
  • Patent number: 9657266
    Abstract: Methods for using vibration to harvest cells grown in 3D culture are provided. The methods entail the application of force to cells attached to a 3D matrix of sufficient amplitude, frequency, and duration to detach cells from the matrix and to flush the detached cells out of the matrix material. An apparatus for performing the methods of the invention as provided.
    Type: Grant
    Filed: April 15, 2012
    Date of Patent: May 23, 2017
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Nirit Drori-Carmi, Barak Zohar
  • Patent number: 9624486
    Abstract: The invention relates to an electrode assembly 20, in particular for applying at least one electric field to adherent cells, comprising at least two electrodes 21, each having at least one surface 32 which is arranged opposite the corresponding surface 32 of the other electrode 21, wherein an electrically insulating material 26 is arranged at least partially between the surfaces 32 of the electrodes 21. The solution according to the invention allows the electric field to be concentrated in the region of the cells to be treated such that a voltage pulse, or the current produced thereby, flows through the cells without the majority flowing away over the cells unused in the electrolyte.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 18, 2017
    Inventors: Herbert Mueller-Hartmann, Andreas Wirth
  • Patent number: 9624516
    Abstract: A method produces a sugar liquid by repeating a sugar liquid production process including (1) to (3): (1) adding a filamentous fungus-derived cellulase to cellulose to perform primary hydrolysis; (2) adding a fresh filamentous fungus-derived cellulase to the hydrolysate in Step (1) to perform secondary hydrolysis; and (3) subjecting the hydrolysate in Step (2) to solid-liquid separation to obtain a sugar liquid, from which a recovered enzyme is obtained; wherein the recovered enzyme obtained in Step (3) is used for Step (1) of the next and later sugar liquid production processes.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: April 18, 2017
    Assignee: Toray Industries, Inc.
    Inventors: Hiroyuki Kurihara, Atsushi Minamino, Yuki Yamamoto, Katsushige Yamada
  • Patent number: 9616152
    Abstract: Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: April 11, 2017
    Assignee: AlloSource
    Inventors: Adrian C. Samaniego, Ross M. Wilkins
  • Patent number: 9592255
    Abstract: The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: March 14, 2017
    Inventors: Lisa M. Larkin, Ellen M. Arruda, Jennifer Baltich, Aaron Adams, Leah Hatch-Vallier
  • Patent number: 9574169
    Abstract: The present invention comprises the discovery and development of an effective cryoprotectant composition, without containing skim milk or any other animal-derived compounds, to achieve long-term stability of freeze-dried lactic acid bacteria (LAB), at different temperatures, whereby the retention of viability of the freeze-dried LAB after 6 months of storage, preferably after 9 months of storage, more preferably after 12 months of storage is more than 50%. The invention is in the field of producing freeze dried bacteria, in particular Lactic acid bacteria. More in particular, the invention relates to the use of a novel combination of cryoprotectants for increasing the viability of bacteria after freeze drying, improving the texture of the lyofilized cake for easy grinding and improving the long term stability of the freeze dried bacteria at different temperature conditions. The invention further relates to such freeze dried bacteria for use in food industry or in human or animal health applications.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: February 21, 2017
    Inventors: Sam Corveleyn, Patrick Dhaese, Sabine Neirynck, Lothar Steidler
  • Patent number: 9574976
    Abstract: Embodiments of the invention relate to a device for transporting and preparing cellular material in a fluid for subsequent diagnostic purposes, comprising a cylinder having a fluid-tight screw-on cap and a fluid-tight base part that can be screwed off of the cylinder. The cap can be screwed onto the base part in a fluid-tight matter. The device provides for introducing cellular material to be diagnosed into a fluid in the cylinder, closing the cylinder by a cap for transport, removing the cap, introducing a filter device and concentrating the cellular material on a filter surface, after which the fluid level is at that part of the base part below the connection to the cylinder, disposing of the filtrate, removing the base part, pressing the filter surface onto an object carrier for a cell analysis, and closing the base part by the cap for further transport.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: February 21, 2017
    Inventors: Otto Berners, László Fiac Vass
  • Patent number: 9534261
    Abstract: There is provided a process for effecting growth of phototrophic biomass within the reaction zone of a photobioreactor, comprising, after effecting at least a reduction in the molar rate of supply of carbon dioxide to the reaction zone of the photobioreactor, supplying a gaseous photobioreactor exhaust, that includes diatomic (or molecular) oxygen being generated by photosynthesis effected within the reaction zone by the supplied carbon dioxide, to a combustion zone of a combustor.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 3, 2017
    Assignee: Pond Biofuels Inc.
    Inventors: Jaime A. Gonzalez, Max Kolesnik, Steven C. Martin
  • Patent number: 9516875
    Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: December 13, 2016
    Assignee: TRANSMEDICS, INC.
    Inventors: Robert Fishman, Robert Havener, Ihab A. Fattah, Anas Abdelazim, Scott Newell, Thomas H. Bishop, Tamer I. Khayal, Stanley Kyi, Ron Taylor, Jr., Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed H. Hassanein
  • Patent number: 9511094
    Abstract: Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: December 6, 2016
    Assignee: Cytori Therapeutics, Inc.
    Inventors: John K. Fraser, Marc H. Hedrick, Brian M. Strem
  • Patent number: 9499794
    Abstract: The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: November 22, 2016
    Assignee: BioLamina AB
    Inventors: Karl Tryggvason, Karl Kristian Tryggvason, Anna Domogatskaya
  • Patent number: 9474773
    Abstract: Isolated Lactobacillus strains are useful in preventing or delaying the development of Type 1 Diabetes (T1D). A probiotic composition comprising the Lactobacillus strains and use of the composition in T1D prevention are provided.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: October 25, 2016
    Inventors: Josef Neu, Graciela Liliana Lorca, Eric W. Triplett, Mark A. Atkinson, Desmond A. Schatz
  • Patent number: 9452184
    Abstract: The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: September 27, 2016
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Suzanne T. Ildstad, Mary Jane Elliott
  • Patent number: 9433219
    Abstract: The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: September 6, 2016
    Assignee: The Regents of the University of California
    Inventors: Philippe Rolshausen, Mary Caroline Roper
  • Patent number: 9434979
    Abstract: Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: September 6, 2016
    Inventors: Shin-San Michael Su, Lenny Dang, Stefan Gross, Shengfang Jin, Valeria Fantin
  • Patent number: 9408873
    Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of immune disorders and inflammatory diseases, comprising stem cells that are generated by culturing stem cells expression Nucleotide-binding Oligomerization Domain protein 2 (NOD2) with a NOD2 agonist or a culture thereof.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: August 9, 2016
    Inventors: Kyung Sun Kang, Hyung Sik Kim