Abstract: A method and a system for preventing a network attack, the attack being caused by the presence of worms in the network, is provided. The method includes determining the number of packets being transmitted from each source in the network to a plurality of destinations, the packets being transmitted from a source with a set of characteristics. If the number of packets with the set of characteristics, being transmitted from a source, exceeds a predefined first threshold, then the signature of the packets is stored. Subsequently, if at least one of the pluralities of destinations of the packets identified with the source becomes a source of new packets, the new packets being transmitted to more than one destination; then the new packets are compared with the signature. If at least one new packet matches with the signature, then the worm is to be detected.

Abstract: A method for security information management in a network comprises receiving event information for a plurality of events, wherein the event information for a particular event comprises a plurality of attributes associated with that event. The method continues by assigning a plurality of attribute values to each event, the attribute values of each event defining a point in n-dimensional space. The method continues by generating a first n-dimensional graph comprising a plurality of points, the points corresponding to the events. The method continues by receiving a second n-dimensional graph comprising a plurality of points. The method concludes by combining the first n-dimensional graph with the second n-dimensional graph.

Abstract: A method, system and apparatus are provided for securely connecting a peripheral device to a processing device in a wireless network. The peripheral device makes a request for access to the processing device, which generates a challenge message and prompts a user to respond. The peripheral device is allowed access to the processing device, based on the user's response. If the user's response validates the challenge message, access is allowed; otherwise it is disallowed.

Abstract: A system and method which receives from an application a request to open a file for reading or writing, prompts the user for the file, and then provides a handle or alternate handle to the requesting application, but does not provide the name and path of the file and may not provide the actual handle to the file.

Abstract: A control device is connected to at least one encryption/decryption device via at least one communication device. The control device is connected to a round key generator via at least one further communication device. The control device has at least one external key input, the at least one encryption/decryption device has at least one external data input and at least one external data output, and the at least one encryption/decryption device and the round key generator are decoupled from one another.

Abstract: An Elliptic Curve Cryptography reduction technique uses a prime number having a first section of Most Significant Word “1” states, with N=nm-1+N1B+n0 and a second section with a plurality of “1” or “0” states. The combination of the first section and the second section is a modulus.

Abstract: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to this invention causes the cells to expand surprisingly rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy.

Abstract: The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of pharmaceutical compositions, including pharmaceutical compositions of immunoglobulin and isolated antigen.

Abstract: The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by improving translation from expression cassettes in vitro before producing recombinant hosts.

Abstract: The present invention provides an isolated, purified and characterized human tyrosine hydroxylase (hTH) promoter nucleic acid sequence. The invention further provides a method of selecting TH positive (TH+) cells by preparing a construct comprising a hTH promoter operably linked to a heterologous nucleic acid sequence, for example, green fluorescent protein encoding sequence, and transfecting cells, particularly stem cells, with the construct. The invention also provides a hTH promoter, useful in gene therapeutic applications in driving therapeutic genes or other nucleic acid sequences operably linked to the hTH promoter. Additionally, the invention provides cell lines and transgenic animals expressing a transgene comprising the hTH promoter operably linked to a heterologous sequence, which cell lines and transgenic animals are useful for isolating TH+ cells for transplantation or for screening of therapeutic agents that affect TH+ function.

Abstract: The invention relates to the exploitation of the migratory behavior of mononuclear phagocytes with a view to targeting therapeutic drug delivery. The invention therefore concerns the attachment or incorporation of a therapeutic agent to or into a mononuclear phagocyte and the subsequent migration of the munonuclear phagocyte to a target area.

Abstract: A method of modulating the transcription of one or more genes in a vascular or cardiac cell, wherein the method comprises a step of contacting the cell with a composition comprising one or more double-stranded nucleic acid(s) capable of sequence-specific binding to the transcription factor AP-1 and/or C/EBP or a related transcription factor.

Abstract: The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more cell adhesion factors and one or more cell proliferation factors are seeded and cultured.

Abstract: A non-human mammal which is usefully and effectively applicable to the screening of a substance to be employed for preventing and treating heart failure. This animal is an animal model of heart failure prepared by starting both coronary stenosis and the stenosis of arteries other than the coronary artery and the abdominal artery of a non-human mammal within the same period of time.

Abstract: A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also disclosed. A method for epitope mapping is also disclosed.

Abstract: The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.

Abstract: This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic agent, and at least one adjuvant compound chosen from the polymers of acrylic or methacrylic acid and copolymers of maleic anhydride and alkenyl derivative. The adjuvant compound is preferably a carbomer or an EMA®. This invention also provides a method of enhancing a DNA vaccine and/or the immunogenicity of a DNA vaccine.

Abstract: The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal are provided, such as immunological methods that produce antibodies in the host.

Abstract: A cell composition of endocrine progenitor cells derived from mammalian pancreatic islet cells that can be trans-planted into a diabetic patient such that the cells of the cell composition differentiates into functioning insulin-producing beta cells.

Abstract: The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor of malignant cell transformation, and modulator of oncogenic signaling, wherein introducing RhoB directly, or indirectly via a nucleic acid, into a malignantly transformed cell or a cancerous cell decreases phosphorylation of Erk and Akt proteins inhibiting the PI3-kinase/Akt cell survival pathway and promoting apoptotic cell death. Methods and compositions are disclosed for administering to cancer patients, a prophylactic treatment to minimize the risk of malignant transformation, and advantageous combination of RhoB therapy with existing cancer treatments. The protein RhoB and the variants of the present invention are prenylated with either geranylgeranyl or farnesyl, and provision is made for selection of the prenylating moiety.