Abstract: Various examples described herein are directed to systems and methods for determining an analyte concentration using an analyte sensor. A method may comprise disconnecting an analyte sensor from a measurement circuit and reconnecting the analyte sensor to the measurement circuit after an accumulation period. The method may comprise receiving a signal from the analyte sensor. The signal may be indicative of an amount of charge accumulated on the analyte sensor during the accumulation period. The method may also comprise determining an estimated analyte concentration level based on the received signal.

Abstract: A skin inspection device for identifying abnormalities is described. The device comprises a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; one or more image capture devices having a wide angle lens for capturing an image of the TLC formations and an area of skin of a target located in the inspection area; at least some of the TLC formations have a warped shape while other TLC formations have a non-warped shape; wherein the warped shaped TLC formations and the non-warped TLC formations define a pattern such that when viewed through the wide angle lens both the warped shaped TLC formations and the non-warped TLC formations appear non-warped.

Abstract: Methods, system and apparatus for identifying an extreme epileptic state/event in a patient are provided. In one aspect, at least two seizure events are identified. At least one inter-seizure interval (ISI) value related to the at least two seizure events are determined. The ISI value is compared to at least one reference value. An occurrence of an extreme seizure event is determined based upon the comparison of the determined ISI value to the at least one reference value. In another aspect, a first seizure event is detected. At least one body index affected by the first seizure event is determined. A second seizure event is detected. An occurrence of an extreme seizure event is determined based at least in part in response to a determination that the second seizure event occurred prior to the body index value returning to a reference value.

Abstract: Gesture-informed patient management systems and related medical devices and operating methods are provided. A method of operating a medical device capable of influencing a physiological condition of a patient involves obtaining first sensor measurement data from a sensing arrangement associated with a first location on a body of the patient and capable of detecting physical movement by the patient, obtaining second sensor measurement data from a second sensing arrangement having a second location different from the first location, predicting an occurrence of an event based at least in part on the first sensor measurement data in a manner that is influenced by the second sensor measurement data, resulting in a predicted occurrence of the event, and automatically configuring operation of the medical device to influence the physiological condition of the patient in a manner that is influenced by the predicted occurrence of the event.

Abstract: A wearable device for a noninvasive measurement of a user's body temperature can include a housing, a first substrate coupled to the housing and having an opening, a second substrate coupled to the first substrate and configured to secure to skin of a user, a mounting frame enclosed by the housing and the first substrate, a circuit board secured by the mounting frame, a temperature sensor coupled to the circuit board and configured to determine a body temperature of the user, and a thermally conductive probe. The thermally conductive probe is secured by the mounting frame and positioned proximate to the first temperature sensor. The thermally conductive probe extends at least partially through the opening in the first substrate and transmits a thermal energy from a portion of the user's skin to the first temperature sensor.

Abstract: An apparatus for estimating bio-information is provided. The apparatus for estimating bio-information includes: a pulse wave sensor configured to measure a pulse wave signal from an object; a force sensor configured to measure force exerted between the object and the pulse wave sensor; and a processor configured to obtain an oscillogram by using the pulse wave signal and the force, to determine a first mean arterial pressure (MAP) based on the obtained oscillogram, to extract additional information in an interval preceding a point of the first MAP of the oscillogram, to obtain a second MAP based on the first MAP and the additional information, and to estimate bio-information based on the obtained second MAP.

Abstract: An apparatus for vital sign extraction. The apparatus may receive a vital signal of a subject from a sensing device. The apparatus may also perform a preprocessing procedure on the vital signal via bandpass filtering and normalization to obtain a preprocessed signal. The apparatus may also perform a time-frequency analysis of the preprocessed signal, and estimate a heart rate of the subject from a dominant component of the preprocessed signal by finding location of a maximum spectral energy of the time-frequency analysis. In addition, the apparatus may identify guard components in the preprocessed signal in view of the dominant component, and derive a respiratory rate of the subject from a length of an interval between the dominant component and each of the guard components.

Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.

Abstract: An electrode according to the present invention contains a conductive polymer; a binder resin; and a plasticizing agent, wherein the electrode has a plate shape having a pair of principal surfaces parallel to each other, and wherein a ratio of a content of the plasticizing agent to a content of the conductive polymer being 0.5 to 500.0 in a surface part of the electrode located at less than or equal to 1 ?m from a surface of the electrode.

Abstract: The present invention relates to a non-contact portable tonometry system and tonometry method using a difference in infrared intensity. A nozzle module receives compressed air from a compressed air supply source and sprays the same through an air spray port to a cornea of a subject, thus to cause corneal deformation. An infrared ray sensor is disposed in the nozzle module to emit infrared rays to the cornea and measure an amount of light reflected from the cornea. A controller converts the amount of light measured by the infrared ray sensor before and after the deformation of corneal into intraocular pressure.

Abstract: A method includes engaging Parkinson's Disease (PD) subjects in a continuous motor performance task that elicits natural motor variability, quantifying natural motor variability of each PD subject with an array of motor metrics at short timescales, applying a machine-learning classification or regression algorithm to determine weights for each of these metrics to maximally differentiate each patient's motor performance from that of controls performing the same task, and combining the weights to determine a scalar metric of motor performance for each short epoch of motor behavior.

Abstract: The present invention relates to an apparatus (10) apparatus for the detection of carbon dioxide. It is described to place (210) a part of a housing in contact with a skin area of a patient. the part of the housing and a gas measuring chamber within the housing are configured such that gases diffusing through the skin area of the patient enter the gas measuring chamber. radiation is emitted (220) from a radiation source within the housing, wherein at least some of the radiation emitted by the radiation source enters the gas measuring chamber. The radiation entering the gas measuring chamber has wavelengths that extend over an absorption band of carbon dioxide and has wavelengths that extend over a region other than the absorption band of carbon dioxide. A radiation filter is positioned (230) relative to the gas measuring chamber such that an interaction radiation path is defined between the radiation source through the gas measuring chamber to the radiation filter.

Abstract: This document discusses, among other things, systems and methods to receive physiologic information from a patient and to generate a heart failure status using the received physiologic information. Based on the received physiologic information, the generated heart failure status can be classified into at least one of a set of predetermined phenotype clusters.

Abstract: Methods, systems, and devices for detection of medical conditions using respiration rate data are described. A method may include receiving physiological data associated with a user, the physiological data being continuously collected via a wearable device associated with the user, determining a set of respiration rate values for the user over a time interval based on the physiological data, and determining one or more respiration rate parameters associated with a change of the set of respiration rate values over the time interval. The method may further include determining one or more condition risk metrics associated with one or more medical conditions based on the one or more respiration rate parameters, where the one or more condition risk metrics associated with a relative probability that the user is associated with a respective medical condition.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or effectiveness of cardiopulmonary resuscitation (“CPR”), in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid estimation of a patient's compensatory reserve index (“CRI”) before, during, and after CPR is performed, and using the CRI and variations in CRI values to determine, in some instances, in real-time, the effectiveness of CPR that is performed.

Abstract: Vision-based stimulus monitoring and response systems and methods are presented, wherein detection, via image(s) of a patient through an external stimulus, such as a caregiver, prompts analysis of the response of the patient, via secondary patient sensors or via analysis of patient image(s), to determine an autonomic nervous system (ANS) state.

Abstract: Apparatus and method for determining the immiittance of a middle ear for clinical-audiometric investigations in a wide range of frequencies at ambient pressure, based on MEMS microphone technology and on measuring the acoustic pressure wave and the corresponding acoustic velocity wave by means of a pressure-pressure probe.

Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.

Abstract: A cognitive platform is disclosed that is configured for either or both of assessing or enhancing the cognitive abilities of an individual based on implementing one or more navigation task(s) in an environment. A first task is rendered that requires the individual to rely on allocentric navigation capabilities to navigate in the environment based on a first set of views of portions of the environment rendered at the user interface. A second task is rendered that requires the individual to rely on egocentric navigation capabilities to navigate in the environment. An indication of a cognitive ability in the individual can be generated based on the difference in the individual's performance at the first task as compared to the second task.

Abstract: Skin-mountable electronic devices and methods suitable for fabricating and using the devices. One embodiment of such a device includes a flexible structure comprising a pattern of individual interconnected traces each comprising a portion of an electrically-conductive layer that overlies and directly contacts an underlying portion of an elastomeric layer. At least some of the portions of the electrically-conductive layer within the pattern are functional electrodes of the skin-mountable electronic device.