Abstract: Process for the industrial synthesis of isoindoline by catalytic hydrogenation of phthalonitrile, and its application in the synthesis of 2-(S)-benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)-butyric acid, its pharmaceutically acceptable salts and its hydrates.
Type:
Grant
Filed:
February 16, 2001
Date of Patent:
November 20, 2001
Assignee:
Adir et Compagnie
Inventors:
Jean-Claude Souvie, Claude Fugier, Jean-Pierre Lecouve