Patents Examined by V Balasubramanian
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Patent number: 6878663Abstract: An aromatic compound represented by the general formula Ar1X is reacted with a palladium compound and a phosphine derivative, in the presence of a first basic substance, thereby producing a palladium-complex compound represented by the general formula Ar1—PdL2X. This palladium-complex compound is reacted with a benzoic acid represented by the general formula Ar2—COOH, in the presence of a second basic substance, thereby producing another palladium-complex compound represented by the following general formula. The above palladium-complex compounds are useful as catalysts and can be produced easily by the above reactions. In the above general formulas, Ar1 is an aryl group; and X is a halogen that is fluorine, chlorine, bromine or iodine, trifluoromethanesulfonate group, an alkylsulfonate group having a carbon atom number of 1-4, or a substituted or unsubstituted arylsulfonate group; each L is independently a phosphine ligand; and Ar2 is an aryl group.Type: GrantFiled: April 5, 2002Date of Patent: April 12, 2005Assignee: Central Glass Company, LimitedInventors: Takashi Kume, Satoru Narizuka, Makoto Koide, Koichi Mikami, Manabu Hatano, Masahiro Terada
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Patent number: 6169182Abstract: The invention relates to a novel process for preparing substituted cyanophenyluracils of the general formula (I) in which R1, R2, R3 and R4 are each as defined in the description, said compounds being known as herbicidally active compounds, to novel substituted N-(cyanophenyl)aminoalkenamides as intermediates therefor and to an inventive process for their preparation.Type: GrantFiled: July 30, 1998Date of Patent: January 2, 2001Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Reinhard Lantzsch, Heinz-J{umlaut over (u)}rgen Wroblowsky
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Patent number: 6156894Abstract: A process is useful for making compounds of the formula: wherein R is hydro, methyl, or fluoro.Valuable intermediates in this process include: ##STR1## wherein R is hydro, methyl, or fluoro, and L is a leaving group.Type: GrantFiled: March 24, 1999Date of Patent: December 5, 2000Assignee: Hoffman-La Roche Inc.Inventors: Robert Clark Chapman, Jolyon Perkins
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Patent number: 6133258Abstract: Neuroprotective agents based on inhibition of kainic acid neurotoxicity and compounds useful as neuroprotective agents based on inhibition of kainic acid neurotoxicity. An inhibitors of kainic acid neurotoxicity, comprising as an active ingredient a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, and a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR2## R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or a lower alkyl, cycloalkyl, alkenyl, aryl, carboxyl or lower alkoxycarbonyl group which may have substituent(s), or are not present, with the proviso that R.sup.2 and R.sup.Type: GrantFiled: May 13, 1998Date of Patent: October 17, 2000Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Jun-ichi Shishikura, Hiroshi Inami, Tomoyuki Yasunaga, Masaaki Hirano, Shuichi Sakamoto, Kazushige Ohno, Masamichi Okada, Shin-ichi Tsukamoto
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Patent number: 6130332Abstract: The object of the present invention is to provide a method for producing substituted-1,3,5-triazine derivatives at high yield, in which at least one of carbon atoms in the ring thereof is substituted by a secondary amine group having at leat one of alkyl groups. The method of the present invention is a method for alkylation of 1,3,5-triazine derivatives, characterized by reacting 1,3,5-triazine derivatives (melamines, melamine derivatives, various kinds of guanaminde derivatives, etc.) which has at least one or more amino groups or mono-substituted amino groups on carbon atom of the ring thereof, with aldehydes or ketones alcohols in the presence of a catalyst of a metal of group VII and/or group VIII in the periodic table and a hydrogen-containing gas to alkylate said at least one of amino groups or mono-substituted amino groups.Type: GrantFiled: February 7, 1997Date of Patent: October 10, 2000Assignee: Nissan Chemical Industries, Ltd.Inventors: Norio Tanaka, Kenichi Mizusawa, Makoto Ishikawa, Yasuo Fukue, Isao Hashiba, Yoshihisa Watanabe
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Patent number: 6130223Abstract: The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically acceptable salts, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and n have the meaning cited in claim 1. Said compounds exhibit a phosphodiesterase V inhibition and can be used in the treatment of cardiovascular dieases and for the treatment and/or therapy potency disorder.Type: GrantFiled: June 11, 1999Date of Patent: October 10, 2000Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rochus Jonas, Pierre Schelling, Maria Christadler, Franz-Werner Kluxen
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Patent number: 6127376Abstract: This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: ##STR1## wherein Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. These compounds are useful as anti-coagulants.Type: GrantFiled: December 4, 1998Date of Patent: October 3, 2000Assignee: Berlex Laboratories, Inc.Inventors: David D. Davey, Gary B. Phillips
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Patent number: 6127538Abstract: A method for modifying 1,3,5-triazine derivatives characterized by heating and reacting a 1,3,5-triazine derivatives having at least one amino or mono-substituted amino group on a carbon atom or atoms on its ring with an alcohol in the presence of a metal catalyst and a hydrogen atom to introduce an alkyl group or an alkenyl group into each amino or mono-substituted amino group; another method for modifying 1,3,5-triazine derivatives characterized by heating and reacting a 1,3,5-triazine derivatives having at least one amino or mono-substituted amino group on a carbon atom or atoms on its ring with a dihydric alcohol in the presence of a metal catalyst and a hydrogen atom to introduce an alkyl group having a hydroxyl group into each amino or mono-substituted amino group; and 1,3,5-triazine derivatives obtained by the methods. The various modified sustituted 1,3,5-triazine derivatives thus produced are generally obtained as a mixture.Type: GrantFiled: June 22, 1998Date of Patent: October 3, 2000Assignee: Nissan Chemical Industries, Ltd.Inventors: Norio Tanaka, Yasuo Fukue, Kenichi Mizusawa, Makoto Ishikawa
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Patent number: 6121303Abstract: A compound of formula I ##STR1## wherein R.sub.1 is nitro, halogeno or cyano group and R.sub.2 is a group selected from ##STR2## wherein Y and Z are independently oxygen, sulfur or NR, wherein R is hydrogen, straight or branched C.sub.1-8 alkyl, C.sub.5-7 cycloalkyl, phenylC.sub.1-8 alkyl or phenyl group and X.sub.1 and X.sub.2 are NR, where R is hydrogen, straight or branched C.sub.1-8 alkyl, C.sub.5-7 cycloalkyl, phenylC.sub.1-8 alkyl or phenyl group, or a pharmaceutically acceptable salt or ester thereof. Pharmaceutical compositions are also disclosed.Type: GrantFiled: February 23, 1999Date of Patent: September 19, 2000Assignee: Orion-yhtyma OyInventors: Reijo Backstrom, Erkki Honkanen, Inge-Britt Linden, Erkki Nissinen, Aino Pippuri, Pentti Pohto, Tapio Korkolainen
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Patent number: 6121445Abstract: A 1,3,5-triazine derivative salt of a polyacid comprising phosphorus, sulfur and oxygen, which has a solubility of from 0.01 to 0.10 g/100 ml in water (25.degree. C.) and a pH of from 2.0 to 7.0 as a 10 wt % aqueous slurry (25.degree. C.), and which is obtained from the following steps (a) and (b):(a) a step of obtaining a reaction product by mixing melamine, phosphoric acid and sulfuric acid at a temperature of from 0 to 330.degree. C. in such ratios that the melamine is from 1.0 to 4.0 mols per mol of the total molar amount of the phosphoric acid (as calculated as orthophosphoric acid content) and the sulfuric acid (as sulfuric acid content), and the sulfuric acid (as sulfuric acid content) is from 0.05 to 20 mols per mol of the phosphoric acid (as calculated as orthophosphoric acid content), and(b) a step of baking the reaction product obtained in step (a) at a temperature of from 340 to 400.degree. C. for from 0.1 to 30 hours; and a process for its production.Type: GrantFiled: September 3, 1999Date of Patent: September 19, 2000Assignee: Nissan Chemical Industries, Ltd.Inventors: Keitaro Suzuki, Masuo Shindo, Motoko Iijima
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Patent number: 6110925Abstract: The present invention is directed to anti-bacterial and anti-tumor agents and the synthesis thereof.Type: GrantFiled: August 6, 1998Date of Patent: August 29, 2000Assignee: Research Corporation Technologies, Inc.Inventors: Robert M. Williams, Chenguang Yuan
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Patent number: 6103732Abstract: Carboxylic acid derivatives of the formula I ##STR1## where the radicals have the meanings stated in the description, and the preparation of these agreements [sic] and their use as drugs are described.Type: GrantFiled: October 8, 1998Date of Patent: August 15, 2000Assignee: BASF AktiengesellschaftInventors: Wilhelm Amberg, Andreas Kling, Dagmar Klinge, Hartmut Riechers, Ernst Baumann, Liliane Unger, Manfred Raschack, Stefan Hergenroder, Sabine Schult
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Patent number: 6100246Abstract: There are provided novel compounds of formula (I) ##STR1## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; or a five membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S; and R.sup.1, R.sup.2, R.sup.3 and X are as defined in the Specification and pharmaceutically acceptable salts thereof and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment and prophylaxis of inflammatory disease and pain.Type: GrantFiled: May 8, 1999Date of Patent: August 8, 2000Assignee: Astra Pharmaceuticals LimitedInventors: Peter Richard Hamley, Thomas McInally, Alan Charles Tinker
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Patent number: 6096745Abstract: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of heteroaryl derivatives of imidazolone compounds of Formula 1. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.Type: GrantFiled: March 3, 1999Date of Patent: August 1, 2000Assignee: Bristol-Myers Squibb Co.Inventors: Graham S. Poindexter, Kevin Gillman
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Patent number: 6096890Abstract: This invention provides a convenient process for the preparation of monoacylhydrazines from carboxylic acids or their salts and hydrazine or substituted hydrazine in the presence of a 1,3,5-triazine substituted with at least one chloro or fluoro. The resulting monoacylhydrazine can further be converted to a diacylhydrazine by effectively either repeating the reaction or through reaction with a carboxylic acid chloride.Type: GrantFiled: August 25, 1999Date of Patent: August 1, 2000Assignee: Rohm and Haas CompanyInventors: Catherine Dubuisson-Brengel, Heather Lynnette Rayle
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Patent number: 6087498Abstract: There is provided a process for the preparation of unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds. The unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds are useful as pesticidal agents.Type: GrantFiled: March 16, 1999Date of Patent: July 11, 2000Assignee: American Cyanamid CompanyInventors: William Wakefield Wood, Salvatore John Cuccia, Robert Brigance
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Patent number: 6087368Abstract: Novel quinazolinone compounds, methods of using such compounds in the treatment of cGMP-associated conditions such as erectile dysfunction, and pharmaceutical compositions containing such compounds.Type: GrantFiled: May 28, 1999Date of Patent: July 11, 2000Assignee: Bristol-Myers Squibb CompanyInventors: John E. Macor, David P. Rotella, Harold N. Weller, III, David W. Cushman, Joseph P. Yevich
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Patent number: 6083942Abstract: Pesticidal substituted oxadiazines having the formula: ##STR1## wherein R is a substituted or unsubstituted heterocyclic group, pesticidal compositions containing these oxadiazines, and methods for their use.Type: GrantFiled: March 8, 1999Date of Patent: July 4, 2000Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Co.Inventors: Mark Achiel Dekeyser, Paul Thomas McDonald
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Patent number: 6080740Abstract: The present invention is directed to spiro-ketal derivatives of the formula (I): ##STR1## (wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.9a, R.sup.9b, m and n are defined herein) which are tachykinin antagonists and are useful, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.Type: GrantFiled: August 13, 1998Date of Patent: June 27, 2000Assignee: Merck Sharp & Dohme Ltd.Inventors: Jonathan David Moseley, Christopher John Swain
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Patent number: 6080774Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: ##STR2## R.sup.2 and R.sup.3 are each independently (a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.6 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ;(i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ;(j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or(k) --Z.sup.4 --N(R.sup.11)--Z.sup.5 --NR.sup.9 R.sup.10 ;and the remaining symbols are as defined in the specification.Type: GrantFiled: October 8, 1996Date of Patent: June 27, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Natesan Murugesan, Joel C. Barrish, John Lloyd