Patents Examined by V. Ryan Ryan
  • Mutant enterotoxin effective as a non-toxic oral adjuvant
    Patent number: 6019982
    Abstract: Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This enterotoxin is used in combination with an unrelated antigen to achieve an increased immune response to said antigen when administered as part of an oral vaccine preparation.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: February 1, 2000
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: John D. Clements, Bonny L. Dickinson