Abstract: The products of the invention are obtained by a method which consists of: oxidizing cytidine-diphosphocholine, fixing the dialdehyde obtained by the preceding oxidation of the ribose of the cytidine on NH.sub.2 groups of the amino compound in alkaline aqueous solution, stabilizing the coupling thus formed by reduction and recovering the macromolecular product thus obtained in the form of an aqueous solution. The latter can be freeze-dried to provide a powder suitable for preservation. The coupling occurs between the oxidized ribose groups of the cytidine-diphosphocholine and the lysine residues of the amino compounds. The products of the invention are suitable as vaccines against parasites belonging to the class of those including molecules bound to a phosphorylcholine residue, such as intestinal or respiratory parasites.

Abstract: A process for preparing a water-soluble alkyd resin, which comprises(1) reacting(i) at least one of(a) a 1,2-epoxyalkane containing 6 to 28 carbon atoms,(b) a straight-chain internal epoxyalkane containing 6 to 20 carbon atoms,(c) a mixture of one or more of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b), or(d) a mixture of one or more of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b) and an unsaturated fatty acid containing 12 to 18 carbon atoms in a molar ratio of about 4:1 to about 2:1 of the 1,2-epoxyalkane (a) and/or the internal epoxyalkane (b) to the unsaturated fatty acid;with(ii) at least one of(a') an aromatic carboxyl compound selected from the group consisting essentially of phthalic anhydride, isophthalic acid, terephthalic acid, an ester of isophthalic acid and an ester of terephthalic acid,(b') a mixture of two or more of the aromatic carboxyl compounds (a'), or(c') a mixture of one or more of the aromatic carboxylic compounds (a') and an aliphatic dicarboxylic acid ha

Abstract: This invention relates to a method for the removal of heparin from heparin-containing blood plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

Abstract: Particular aqueous gels, epoxy resin compositions and optional additives such as diluents, retarders and accelerators are described which produce a practical composition and method for in situ sand consolidation and gravel packing by which a resin coated sand is positioned in a desired location and cured by an internal catalyst to form a porous permeable or plugged consolidated mass.

Abstract: The invention relates to antiplasmin, a newly isolated constituent of the human blood plasma and to its method of isolation. Further, an antiplasmin-antiserum together with its preparation and utilization, and a method of determining antiplasmin in blood samples are disclosed.

Abstract: Thermosettable polyester resin compositions, suitable for use in powder coating applications, derived from a dicarboxylic aromatic acid component (e.g., 1,4-benzenedicarboxylic acid), a trihydroxy alkyl component (e.g., 2-ethyl-2-(hydroxymethyl)-1,3-propanediol), a diol component (e.g., 2,2-dimethyl-1,3-propanediol) and a dihydroxy alkyl compound having 4 to 10 carbon atoms in the primary carbon chain between the hydroxyl moieties (e.g., 1,6-hexanediol). Polyesters of the present invention have a number average MW of from about 2,000 to about 6,000, a combined acid and hydroxyl number of about 35 to about 70 milligrams of KOH per gram of polyester, and a glass transition temperature of about 35.degree. C. to about 50.degree. C.

Abstract: A method for the volumetric inclusion and grafting of hydrophilic compounds in a hydrophobic substrate, comprising the steps of immersing said hydrophobic polymerized substrate in a solution containing hydrophilic monomers in the presence of at least one polymerization inhibitor, and irradiating said solution by means of an ionizing radiation, in order to graft and polymerize the hydrophilic inclusions generated by the hydrophilic monomers in said substrate.

Abstract: A copolymerizable composition containing an unsaturated polyester resin and a metal accelerator, suitable for copolymerization with an ethylenically unsaturated monomer, has incorporated therein as a peroxide initiator composition an alkylaldehyde peroxide which may be unsubstituted, or alkyl- or aryl-substituted, the alkylaldehyde peroxide containing not more than 20 carbon atoms and at least 1.5 active oxygen atoms per carbonyl group of said alkylaldehyde.

Abstract: A predetermined mass comprising an acrylate salt and acrylamide is exposed to a controlled intensity and dose of ionizing radiation effecting simultaneous cross-linking and polymerization thereof to form a polyelectrolyte hydrogel. The resulting hydrogel is an insoluble hydrophilic copolymer which can contain or when dried absorb large quantities of aqueous fluids.

Abstract: A method for the radioimmunoassay of PGE.sub.1 -type and PGE.sub.2 -type compounds and PGX is disclosed which utilizes antibodies formed against a prostaglandin mimic.Conjugates are disclosed which are formed by attaching a prostaglandin mimic to a carrier molecule.Antibodies are disclosed which are specific against PGE.sub.1 -type and PGE.sub.2 -type compounds, PGH.sub.2, and PGX.Complexes are disclosed which are formed by binding an antibody raised against a prostaglandin mimic with its corresponding authentic prostaglandin.

Abstract: Immunosuppressive agents which are conjugates of an antigen linked to a D-glutamic acid:D-lysine copolymer are disclosed. Also disclosed are methods of preparing the conjugates and therapeutic methods for inducing immunological tolerance to antigens.

Abstract: A pregnancy-specific .beta..sub.1 -glycoprotein, characterized by an electrophoretic migration speed in agar gel in the range of the .beta..sub.1 -globulins, a sedimentation constant of 4.6 S.+-.0.5 S, a molecular weight of 100 000.+-.15 000, an extinction coefficient E.sub.1cm.sup.1% of 11.6.+-.0.5 (278 m.mu.; 1/15-molar phosphate buffer, pH 7.0), a carbohydrate content of 28.05.+-.1.55%, comprising 10.7.+-.1.0% of hexoses, 10.0.+-.0.5% of hexosamine, 0.55.+-.0.05% of fucose and 7.0.+-.0.5% of neuraminic acid, and process for isolating it from the placenta or blood or urine of pregnant women. This protein may be used as a reagent and for the preparation of antisera as reagents for the detection of pregnancy and for pre-natal supervision.

Abstract: A process for continuously producing dried protein concentrates, namely blood meal, from an aqueous solution of animal blood, in which the solution is atomized in superheated steam at a temperature of about 400.degree. C. The atomization of the solution is accomplished, at least in part, by a centrifugal atomizer that throws the solution radially outward in an extremely thin layer of finely divided droplets having diameters less than 100 microns. The small droplets pass into the stream of superheated steam, which causes the liquid to evaporate, and the dried blood solids to precipitate to the bottom of the collector where they are discharged by a conveyor. The superheated steam, which was cooled to about 200.degree. C. by the drying process, goes to a cyclone separator which removes any entrained solids, and is then returned to the heat exchanger, where it is again heated to about 400.degree. C. for re-use in the process.

Abstract: A process is disclosed for the separation of macromolecules from a fluid substance containing the macromolecules.The process comprises contacting the fluid substance with discrete porous particles having an interconnected porosity throughout which provides an extended surface area and a pore structure such as will allow the macromolecules to permeate the particles and be sorbed, the discrete porous particles being selected such that a proportion thereof have acidic surfaces for contacting the macromolecules in the fluid substance and a proportion thereof have basic surfaces for contacting the macromolecules in the fluid substance.A process for the separation of protein from milk whey solution is also disclosed.

Abstract: This invention is directed to low molecular weight, solid addition products having a softening point above 100.degree. F. and the method of preparing same and more particularly to the use of said addition products as crosslinking agents in various polymeric powder coatings, e.g. polyesters. The solid, low molecular weight products are derived from the addition reaction of at least one monohydroxy, single-ring aromatic carbon compound and hexakis (alkoxymethyl) amino-triazine.

Abstract: A photopolymerizable system is provided as a latex system that is an oil-in-water polymer emulsion including particulates of water-insoluble polymers in combination with a water-soluble or water-dispersible, light-sensitive polymer having multiple light-sensitive moieties. Prior to coating onto a substrate, the system is a three-phase precursor emulsion of the emulsion particulates, the water phase, and the light-sensitive polymer. After coating, the bulk of the water phase is evaporated off, leaving a two-phase system of the emulsion particulates surrounded by the light-sensitive polymer. When selected areas are subjected to actinic radiation, a water-insoluble matrix is formed, the matrix containing cross-linked light-sensitive polymer having dispersed therethrough and/or included therein the water-insoluble polymer particulates, thus forming oleophilic image areas.

Abstract: There are disclosed thermoplastic and thermosetting polymers which incorporate tungsten and/or molybdenum metal atoms. The metal atoms are incorporated into the polymer by reacting a monomer or polymer containing at least one free carboxyl group with a reaction product of tungsten or molybdenum and pyrrolidine.

Abstract: A radiation curable oligomer which cures to provide a combination of improved elongation and tensile strength is constituted by a selected hydroxy functional polyester having its active hydrogen atoms end-capped by reaction with ethylenically unsaturated monoisocyanate. This polyester is the reaction product of one mole of tris (2-hydroxyethyl) isocyanurate with three moles of saturated dicarboxylic acid and three moles of diol, these proportions being variable within the limits of .+-.20%, the polyester reaction product having an acid value of less than 20, preferably less than 5, and providing hydroxyl-terminated branches having an average length corresponding to a calculated molecular weight of 100-1500.

Abstract: Water and serum soluble cholesterol compounds are prepared by reactively combining certain esters of cholesterol with a solubilizing agent selected from the group consisting of peptides, proteins, water soluble polycarboxylic acids, organic and inorganic water soluble salts of said polycarboxylic acids, and cis-vicinal water-soluble polysaccharides. The water-soluble cholesterol compounds can be lyophilized and added to serum as a standard for the determination of cholesterol in biological fluids either by traditional saponofication methods or by enzymatic methods.

Abstract: A novel melt polymerization process is disclosed for increasing the molecular weight of poly(1,4-butylene terephthalate). This process comprises adding a compound containing at least two aliphatic or cycloaliphatic hydroxyl groups to a low molecular weight poly(1,4-butylene terephthalate) and thereafter melting the polymer in a vacuum until the desired molecular weight is reached.