Abstract: A method is provided for mineralizing a dental surface or subsurface including contacting the dental surface with a protein disrupting agent and stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP).

Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.

Abstract: The present invention relates to a novel pharmaceutical formulation comprising an LTB4 agent at an alkaline pH effective to stabilize the LTB4 agent and provide a formulation with an increased shelf-life. The formulation of the present invention has an increased shelf-life of at least 24 months.

Abstract: The invention relates to the finding that very favorable pharmacokinetic characters are obtained by combining two strontium salts in one pharmaceutical composition. The present invention relates in one aspect to a pharmaceutical composition comprising at least two strontium salts for use as a medicament, and in particular for the treatment and prevention of bone disorders such as osteoporosis. The composition preferably comprises strontium carbonate and strontium chlorides. Further included may be a vitamin D compound, preferably vitamin D3.

Abstract: Antioxidant polymeric compounds are provided that comprise a plurality of monomeric portions, where each monomeric portion includes an antioxidant molecule interposed between at least two acrylate molecules, and where at least one acrylate molecule of each monomeric portion is linked by a diamine molecule to an acrylate molecule of an adjacent monomeric portion to thereby form the polymer. Methods of synthesizing polymeric compounds and methods of using the antioxidant polymeric compounds to reduce oxidative stress are also provided.

Abstract: A method of whitening a tooth surface including contacting the surface of a tooth with an efficacious amount of a substantially non-cytotoxic composition. The non-cytotoxic composition includes chlorine dioxide and no more than about 0.25 milligrams oxy-chlorine anions per gram of the composition.

Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

Abstract: A denture care composition comprising one or more denture care actives and one or more water insoluble carriers, wherein the composition is bioerodible, not a denture adhesive, and substantially free of polybutene with a molecular weight of about 300 to about 3000 when the composition is not an article, and is applied to dentures.

Abstract: Described is the use of specific lactone compounds for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding antioxidant properties.

Abstract: Provided are methods for treating nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery, comprising the co-administration of netupitant, palonosetron and dexamethasone.

Abstract: The present invention relates to a hydrogel suspension which comprises a fine particle and high molecular weight hydroxypropylmethyl cellulose or methylcellulose, which exhibits high transparency and stability; and a manufacturing process thereof.

Abstract: The present invention relates to solid pharmaceutical compositions, in particular to oral contraceptives, comprising a progestogen, such as drospirenone; an estrogen, such as ethinylestradiol; a tetrahydrofolic acid or a pharmaceutically acceptable salt thereof, such as calcium 5-methyl-(6S)-tetrahydrofolate; and at least one pharmaceutical acceptable excipient or carrier. The compositions of the invention provide good stability of the tetrahydrofolic acid upon storage while still ensuring a fast and reliable release of the estrogen and the progestogen present in the composition.

Abstract: Processes for preparing an oral care composition having improved taste, color, odor and/or clarity, wherein said processes comprise the steps of: providing an unfiltered dentifrice component selected from unfiltered alkyl phosphate surfactants, alkyl phosphate ethoxylated surfactants, lauryl sulfate surfactants, betaine surfactants, antibacterial agents, cetyl pyridinium chloride, metal Salts, phytic acids, or mixtures thereof; filtering the unfiltered dentifrice component with an adsorbent to form a filtered dentifrice component; and incorporating the filtered dentifrice component into the oral care composition. In one such process, activated carbon with a median particle size of less than or equal to about 30 ?m, optionally a macro-mesoporous:microporous ratio about 0.

Abstract: The invention concerns an aqueous composition comprising particles of a water-soluble or water-dispersible chemical microgel, associated with at least a water-soluble or water-dispersible crosslinking polymer, differing in composition from the particles; the amount of chemical microgel particles ranging between 0.05 to 40% by dry weight of the composition and the amount of crosslinking polymer being such that the viscosity of the composition is at least three times higher than that of an aqueous solution of chemical microgel particles and than that of an aqueous solution of crosslinking polymer, in similar conditions. The invention also concerns said composition, its use and formulations comprising same.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.

Abstract: The invention provides a composition capable of exerting an excellent whitening effect and imparting gloss to teeth. A method for removing a solid product formed on surfaces of teeth, the method containing applying an oral composition to teeth, wherein the oral composition contains 0.05 to 18% by weight of phytic acid or a salt thereof, and contains no polyvalent cation or contains a polyvalent cation in an amount of less than 0.1 fold mol relative to phytic acid, and wherein the oral composition, as diluted with water to 30% by weight, has a pH of 5.5 to 6.5.

Abstract: An enhancing composition comprising a solvent and a base compound creates an alkaline environment for activating peroxide whiteners and accelerating the formation of free radicals from the peroxide to effect the oxidation of organic molecules causing staining of the dentition. In one embodiment, potassium hydroxide is dissolved in water to form a strongly alkaline liquid. A surfactant may also be included to clean the surfaces of the user's teeth in advance of application of the whitening composition. A peroxide may be added to the enhancing composition to provide a tooth whitening. Other additives for taste, texture, viscosity, and other oral care or oral hygiene purposes may also be included in the enhancing composition. The enhancing composition may be used for advance application to the dentition before a whitening compound. In addition, a rinse may be used after the whitening composition to neutralize the alkaline environment.

Abstract: A method of whitening a tooth surface including contacting the surface of a tooth with an efficacious amount of a substantially non-cytotoxic composition. The non-cytotoxic composition includes chlorine dioxide and no more than about 0.25 milligrams oxy-chlorine anions per gram of the composition.

Abstract: The invention relates to a high-temperature stable, one-part, aqueous tooth bleaching composition for contacting a tooth surface. The composition comprises a bleaching agent comprising a high level of a aqueous hydrogen peroxide. The bleaching agent is derived from multiple components within the composition and comprises at least about 15% by weight of the total composition weight. The Composition also comprises a bleaching agent stabilizer comprising from about 0.01% to about 1.00% by weight of the total composition weight.