Abstract: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

Abstract: Directional propagation editing techniques are described, in one example, a digital image, a depth map, and a direction are obtained by an image editing system. The image editing system then generates features. To do so, the image editing system generates features from the digital image and the depth map for each pixel based on the direction, e.g., until an edge of the digital image is reached. In an implementation, instead of storing a value of the depth directly, a ratio is stored based on a depth in the depth map and a depth of a point along the direction. The image editing system then forms a feature volume using the features, e.g., as three dimensionally stacked features. The feature volume is employed by the image editing system as part of editing the digital image to form an edited digital image.

Abstract: Aspects of the disclosure relate to determining whether a vehicle should continue through an intersection. For example, the one or more of the vehicle's computers may identify a time when the traffic signal light will turn from yellow to red. The one or more computers may also estimate a location of a vehicle at the time when the traffic signal light will turn from yellow to red. A starting point of the intersection may be identified. Based on whether the estimated location of the vehicle is at least a threshold distance past the starting point at the time when the traffic signal light will turn from yellow to red, the computers can determine whether the vehicle should continue through the intersection.

Abstract: The disclosure concerns an augmented reality method in which visual information concerning a real-world object, structure or environment is gathered and a deformation operation is performed on that visual information to generate virtual content that may be displayed in place of, or additionally to, real-time captured image content of the real-world object, structure or environment. Some particular embodiments concern the sharing of visual environment data and/or information characterizing the deformation operation between client devices.

Abstract: The present disclosure provides an indoor positioning method and an electronic device. The method includes: determining a current state of an electronic device according to a current speed parameter of a sensor; if it is determined that the electronic device is currently in a motion state, turning on a Bluetooth positioning circuit in the electronic device; determining a current location of the electronic device according to positioning beacon information obtained by the Bluetooth positioning circuit.

Abstract: The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

Abstract: Systems and methods are provided for monitoring aircraft to mitigate potential loss of communication scenarios. One exemplary method involves monitoring a plurality of communications channels using an onboard communications system, maintaining associations between respective communications channel assignments and respective operational contexts based on the plurality of clearance communications, and in response to detecting a change in an operational context of the aircraft, providing indication of a recommended communications channel based on an association between the recommended communications channel and one of the plurality of different operational contexts corresponding to a current operational context of the aircraft.

Abstract: The present invention relates to a method for producing a component of a turbomachine from a metal alloy as well as a correspondingly produced component, wherein the method includes defining at least one first component region that will have a first property profile, and at least one second component region that will have a second property profile which is different from the first property profile; providing at least one powder of the metal alloy or several different powders of constituents of the metal alloy; additive manufacture of the component from the at least one powder, wherein the powder is melted for cohesive joining of the powder particles to each other and to a substrate or to an already produced part of the component.

Abstract: A system for facilitating sending and receiving of security alerts may include a processor communicatively coupled to a memory and a network interface, the network interface communicatively coupled to a network. A fixed location manager and a roving location manager may be communicatively coupled to the network interface and the network and may be configured to: (i) receive security messages from a plurality of user mobile devices coupled with the network, (ii) create a fixed forum security message and a roving forum security message, each of which is associated with a geographic location of one of the security messages, and (iii) send the fixed forum security message and the roving forum security message to all of the plurality of user mobile devices that comprise a fixed alert area or a roving alert area associate with the geographic location.

Abstract: The disclosure is to constitute, while reducing a cost for collecting training data used in machine learning that makes a control module acquire an ability to control a robot device, the control module operatable in an actual environment by the machine learning. A learning device according to one aspect of the present invention executes machine learning of an extractor by using a first learning data set constituted by a combination of simulation data and first environmental information and a second learning data set constituted by a combination of actual data and second environmental information. Further, a learning device according to one aspect of the present invention executes machine learning of a controller by using a third learning data set constituted by a combination of third environmental information, state information, and a control command.

Abstract: A system for virtual commissioning of a building management system includes one or more memory devices configured to store instructions that, when executed by one or more processors, cause the one or more processors to: receive, at a virtual server, product installation data from a building management system controller installed at a building site via a first connection, the product installation data corresponding to a product installation at the building site; receive, commissioning data from the remote commissioning system via a second connection; configure one or more products installed at the building site to be controlled by the virtual building management system on the virtual server; and selectively transfer control of the one or more products installed at the building site from the virtual building management system hosted at on the virtual server to the building management system controller installed at the building site.

Abstract: Systems and methods for the dynamic mapping of network element data between data models in network devices are disclosed. In particular, a marked-up native data model can be processed to create a mapping schema file based on the markup included in the native data model. This mapping schema file may define mappings between elements of the native data model and corresponding elements of an external data model. The mapping schema file can then be used to dynamically map network element data from the native data model to the external data model, such as when responding to requests for network element data associated with the mapped elements.

Abstract: A system and method for using a portable device to communicate with a vehicle to authorize one or more vehicle operations. The portable device may authorize the vehicle to unlock/lock doors, start the vehicle engine, or mobilize the vehicle, or a combination thereof. The vehicle may include a vehicle transmitter system with one or more transmitters disposed at various locations on the vehicle, and the portable device may be configured to monitor a communication strength between the portable device and the one or more transmitters of the transmitter system. Based on the monitored signal strength, the portable device may determine location information about itself.

Abstract: A sender holds a first platform account with an interaction system. The sender selects a content item to be shared with a recipient. In response to determining that a recipient identifier of the recipient is not linked to a platform account, an off-platform communication is transmitted to a second user device associated with the recipient identifier. The off-platform communication is in an electronic format supported by the second user device and contains a user-selectable registration link. In response to detecting establishment of a second platform account linked to the recipient identifier, the recipient is enabled to access the content item on the second user device via a user interface provided by an interaction application. A relationship between the first platform account and the second platform account is established within the interaction system.

Abstract: Placement of bridges connecting CAE tools and virtual ECU simulation tools is facilitated. A virtual developmental environment apparatus includes a processing execution unit and a memory for storing a MILS model including a controller block and a plant block, first setting information, a program for realizing a function in the controller block used in executing simulation of the virtual ECU, and second setting information. The processing execution unit identifies a controller block in the MILS model based on the first setting information, arranges a bridge for connecting the input port and the output port and the I/O port of the virtual ECU to the input port and the output port of the identified controller block, and connects the bridge and the I/O port of the virtual ECU based on the second setting information.

Abstract: An apparatus comprises a circuitry, a temporary memory and a permanent memory storing necessary information for executing each of a plurality types of processing. The apparatus receives a switching instruction and switches processing executed by the circuitry by varying the necessary information in response to reception of the instruction. The information is read out and loaded into a first region of the temporary memory. If the circuitry is executing at least one of the plurality types of processing when the instruction is made, the apparatus switches the circuitry to a state of being capable of executing the processing by reading out the information of the processing, loading the information into a second region of the temporary memory, and moving or copying the information related to the processing from the second region to the first region in response to the executing processing ending.

Abstract: This disclosure describes a method to minimize disruption for throughput oriented jobs in power oversubscription services with a dynamic control. The mechanism controls power in a hardware-agnostic way, and the policy employs a multi-threshold approach that balances power safety with workload impact. Moreover, an alternative control mechanism ensures proper system operation while power measurements are unavailable.

Abstract: A known-deployed file metadata repository (KDFMR) and analysis engine enumerates reference lists of files stored on a software delivery point (SDP) and compares the enumerated list of files and associated metadata to previously stored values in the KDFMR. If newly stored or modified files are identified, the analysis engine acquires the files from the SDP. Each file is analyzed to determine whether the file is an atomic file or a container file and metadata is generated or extracted. Each file stored in a container file is recursively extracted and analyzed, where metadata is generated for each extracted file and each container file. The KDFMR periodically analyzes the files stored on the SDP for differences to maintain the currency of the KDFMR data with respect to files stored on the SDP. Storage or modification of files on the SDP triggers analysis of the associated file. KDFMR data is updated with metadata determined based on sandbox detonation of files and/or identified artifacts of known-deployed files.

Abstract: In one example in accordance with the present disclosure, a headset is described. The headset includes a sensory input device and a pad surrounding the sensory input device. The pad includes a thermo-electric cooling (TEC) device having a first side and a second side. The first side is to cool and the second side is to heat when a voltage is applied to the TEC device. The pad also includes a cooling layer in contact with the first side of the TEC device and a heat spreading layer in contact with the second side of the TEC device. The pad also includes an enclosing material enveloping the pad.

Abstract: A surface-treated metal material includes a metal sheet, a plating layer formed on the metal sheet and containing aluminum, magnesium, and zinc, and a composite coating formed on a surface of the plating layer, the composite coating including an organic silicon compound, one or two of a zirconium compound and a titanium compound, a phosphoric acid compound, a fluorine compound, and a vanadium compound, wherein, when a surface of the composite coating is analyzed at a spot size of ?30 ?m using micro-fluorescent X-rays, a maximum value of V/Zn, which is a mass ratio of a V content to a Zn content, is 0.010 to 0.100.