Patents Examined by Warren C. Ivy
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Patent number: 5602146Abstract: Compounds of the formula I ##STR1## and tautomeric forms thereof, of the formula Ia, ##STR2## in which the substituents R1-R4 and X and Y have the meanings given; have an antiviral activity.Type: GrantFiled: January 13, 1995Date of Patent: February 11, 1997Assignee: Hoechst AktiengesellschaftInventors: Uta-Maria Billhardt-Troughton, Manfred R osner, Rudolph Bender, Christoph Meichsner
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Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
Patent number: 5475011Abstract: The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.Type: GrantFiled: March 26, 1993Date of Patent: December 12, 1995Assignee: The Research Foundation of State University of New YorkInventors: Iwao Ojima, Ezio Bombardelli -
Patent number: 5401758Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 to R.sup.4 and n are as defined herein and X is O, S or NCN. These compounds have potassium channel opening activity and are useful, therefore for example, as cardiovascular agents.Type: GrantFiled: October 7, 1993Date of Patent: March 28, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Karnail S. Atwal, Francis N. Ferrara
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Patent number: 5359063Abstract: The invention concerns a heterocyclene derivative of the formula I ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety;A.sup.1 is a direct link to X.sup.1 or (1-3C)alkylene;X.sup.1 is oxy, thio, sulphinyl, sulphonyl or imino;Ar.sup.2 is optionally substituted 5-membered heterocyclene moiety;R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the carbon atom to which A.sup.2 and A.sup.3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A.sup.2 and A.sup.3 is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl;or a pharmaceutically-acceptable salt thereof.The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.Type: GrantFiled: March 4, 1993Date of Patent: October 25, 1994Assignees: Imperial Chemical Industries PLC, ICI PharmaInventor: Thomas G. C. Bird
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Patent number: 5241084Abstract: The invention relates to a process for the preparation of ginkgolide B from ginkgolide C and to ginkgolide B thus obtained, the process comprising the following succession of four steps:protecting the 10-hydroxy group of ginkgolide C by conversion to an alkyl ester, the reaction being effected in dimethylformamide at a temperature of from 15.degree. to 50.degree. C. for from 4 to 10 hours;activating the 7-hydroxy group of the resultant 10-protected ginkgolide C by conversion to a (R)thiocarbonyl ester, the activation being effected in basic conditions at a temperature of from 0.degree. to 40.degree. C. for from 1 to 24 hours;deoxygenating the 7-activated group in the resultant 10-protected 7-activated ginkgolide C by treating it with tributyltin hydride or tris-(trimethylsilyl)silane, in an aprotic solvent, in the presence of a free-radical generator, the reaction being effected at a temperature of from 70.degree. to 110.degree. C.Type: GrantFiled: March 30, 1992Date of Patent: August 31, 1993Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventor: Beng-Poon Teng
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Patent number: 5164507Abstract: A substance represented by formula: ##STR1## and a salt thereof, which has antifungal activity and a process for producing the same utilizing a microorganism capable of producing the substance and belonging to the genus Streptomyces.Type: GrantFiled: May 21, 1991Date of Patent: November 17, 1992Assignee: Meiji Seika Kaisha Ltd.Inventors: Toru Sasaki, Akira Shimizu, Junko Yoshida, Hiroomi Watabe, Masao Koyama
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Patent number: 4957963Abstract: An improved aqueous silicone emulsion which cures to a reinforced elastomer upon removal of water is obtained through the use of an anionic, stable dispersion of fumed silica in water as the source of reinforcing silica.Type: GrantFiled: August 30, 1989Date of Patent: September 18, 1990Assignee: Dow Corning CorporationInventors: Stephanie A. Burns, Donald T. Liles, Christine J. Schoenherr
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Patent number: 4855347Abstract: An in-mold lacquer coating, and a process for utilizing the same, for producing a polyurethane-based molded article. The lacquer coating is mold-releasable without the aid of an external mold release agent, is re-coatable after de-molding without additional surface preparation, and comprising a mixture of a pre-reacted aliphatic polyurethane resin, a technically simple silicon resin mold-release agent, and an aromatic, acetate and alcoholic solvent system that is incompatible with the silicon resin and that has constituents with specific gravities less than the silicon resin and with varying rates of evaporation such that the ratio of aromatic to alcoholic solvents decreases as the solvent system evaporates.Type: GrantFiled: September 12, 1988Date of Patent: August 8, 1989Assignee: Moline Paint Manufacturing Co.Inventors: Brian J. Falline, Bruce W. Weihrauch