Abstract: A life support system for providing a growth medium for at least one photosynthetic micro-organism and for converting CO2 to O2, with reduced water use that is as low as about 4 percent of the corresponding amount of water normally required for conventional micro-organism growth. The system includes a liquid transport capillary channel, a mixed culture photosynthetic biofilm and a liquid transport substrate that is positioned between and contiguous to the capillary channel and the biofilm, where the liquid transport rate is adjustable by adjustment of the local humidity. Approximately uniform radiation is received by the biofilm and contributes to microorganism growth.
Type:
Grant
Filed:
June 27, 2013
Date of Patent:
September 11, 2018
Assignee:
The United States of America as Represented by the Administrator of the NASA
Inventors:
Halil Berberoglu, Thomas E. Murphy, Leslie E. Bebout, Erich D. Fleming
Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.
Type:
Grant
Filed:
October 7, 2011
Date of Patent:
December 9, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, Xenopus oocytes. The invention further provides software for controlling, acquiring, and recording data relating to electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, oocytes. This invention increases the throughput rate for experiments and assays employing receptors and ion channels expressed in biological membranes of test subjects, such as, for example, oocytes. In the case of an oocyte, these receptors and channels may be natively expressed (endogenous), may be placed into the oocyte (exogenous), or may be expressed from other RNA or DNA previously placed into the oocyte (exogenous).
Type:
Grant
Filed:
February 23, 2001
Date of Patent:
March 14, 2006
Assignee:
Abbott Laboratories
Inventors:
Jonathan D. Trumbull, Daniel C. Bertrand, Clark A. Briggs, David G. McKenna, Eugene S. Maslana, David P. Blanchard, Jeffrey Y. Pan, Peter Bojan, Thomas A. Nemcek