Patent number: 4728733
Abstract: There are disclosed novel antibacterial compounds having the formula ##STR1## wherein R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclo lower alkyl, aryl of 6-12 carbon atoms, all the said foregoing groups being optionally substituted with carboxy, lower alkoxycarbonyl, phenoxycarbonyl, amino, mono- or di-lower alkyl substituted amino, hydroxy, lower alkoxy, phenoxy, carbamoyl, lower alkyl carbonyl, benzoyl, cyano, nitro, formamido, lower alkanoylamino or benzamido;R.sup.1 is hydrogen, lower alkyl or an alkali metal cation;A is ##STR2## R.sup.2 and R.sup.3 are each individually hydrogen, lower alkyl, carboxy, lower alkoxycarbonyl, cyano, nitro, trifluoromethyl, phenyl or naphthyl; or R.sup.2 and R.sup.3 taken together represent ##STR3## or a 5- or 6- membered unsaturated aza-, diaza-, triaza-, tetraza-, thia-, thiaza-, oxathia-, oxathiaza-, oxa-, dioxa-, oxaza- or oxadiazacyclic moiety; and the dotted line denotes an optional double bond; andR.sup.4 is hydrogen, lower alkyl, phenyl or naphthyl.
Type:
Grant
Filed:
November 25, 1985
Date of Patent:
March 1, 1988
Assignee:
American Home Products Corporation
Inventors:
Jerauld S. Skotnicki, Donald P. Strike
Patent number: 4725597
Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are independently hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyl, alkoxy of 1 to 4 carbon atoms, alkanoyloxy of 1 to 4 carbon atoms, halogen, trihalomethyl, di(lower alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, nitro, cyano or alkanoyl of 1 to 3 carbon atoms;R.sub.7 and R.sub.8 are independently hydrogen, methyl, hydroxyl, carboxyl, (alkoxy of 1 to 4 carbon atoms)carbonyl, hydroxymethyl, phenyl, or p-chlorophenyl;R.sub.9 and R.sub.10 are independently hydrogen or methyl;j and k are independently 0, 1, 2, or 3, their sum being no more than 4;m and n are independently 0, 1, 2, or 3, their sum being no more than 4;A is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --;R.sub.7 and R.sub.9 together are oxo, provided k is other than o;R.sub.8 and R.sub.10 together are oxo, provided m is other than o;R.sub.11 and R.sub.
Type:
Grant
Filed:
September 24, 1984
Date of Patent:
February 16, 1988
Assignee:
Boehringer Ingelheim Ltd.
Inventors:
John P. Devlin, Daniel W. McNeil, James J. Keirns, Edward L. Barsumian