Abstract: Disclosed herein are materials, articles of manufacture, and methods for decreasing, mitigating, removing or precluding formation of an amount of a nitrosating agent and/or an N-nitroso compound, including an N-nitrosamine, in an enclosure of a pharmaceutical drug package to inhibit a potential adverse health effect on a patient associated with the nitrosating agent or N-nitroso compound. The package contains an active agent and a pharmaceutical dosage form in an enclosure of the package. The active agent, consisting essentially of sodium bicarbonate in a granular, particulate or powdered form, is effective to decrease, mitigate, remove or preclude the formation of an amount of the nitrosating agent and/or N-nitroso compound in the enclosure and/or in the pharmaceutical dosage form. Also provided are drug delivery systems including a blister pack configured to house multiple pharmaceutical dosage forms, the blister pack including an active agent as discussed above.

Abstract: Disclosed is a drug delivery system that specifically carries and releases an active substance to a target organ or tissue. The coating of the shape memory component constituting the drug delivery system enhances the biocompatibility and controlled delivery of the active substance previously loaded into the coating material to the target organ or tissue.

Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed to yield a stabilizing effect without altering morphological properties of a first fiber system. By addition of a stabilizing fiber population one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. In one particular abstract, medical barrier materials may be formed from the electrospun materials to provide improved medical barriers for treatments.

Abstract: The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as sup-ports comprising the viral micro particles for the locating the viral microparticles in a wound or in the vicinity of a wound.

Abstract: Disclosed herein are exemplary medical devices for controlled delivery of material compositions, particularly occlusive, therapeutic, or diagnostic compositions.

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: An embodiment of the present invention relates to amino acid-containing granules containing an amino acid as a main component, the amino acid-containing granules having an average particle diameter of 150 ?m to 500 ?m and a homogeneity U of 0.70 or less, in which the average particle diameter and the homogeneity U are determined by the following measurement method.

Abstract: A formulation of naltrexone that ameliorates undesirable localized reactions at the site of implantation.

Abstract: The invention belongs to the technical field of hydrogel materials, and specifically relates to a self-regulating photo-curable cooling hydrogel and a preparation method and an application thereof. The self-regulating photo-curable cooling hydrogel comprises the following raw materials in parts by weight: 10-17 parts of cooling matrix, 18-33 parts of acrylamide-13C3, 27-42 parts of glycerol, 5 parts of TPGDA (tripropylene glycol diacrylate), 0.05-0.15 parts of crosslinking agent, and 0.1-0.3 parts of photoinitiator. By constructing a synergistic system of antifreeze protein and konjac glucomannan skeleton, the gelation of an isotope-labeled monomer and the purpose of self-regulating cooling are achieved. It can be used for preparing drug-loaded gel dressings, cooling gel dressings, and in-situ injectable gel products. The photo-curable crosslinking technology facilitates the rapid molding of gel dressings and improves the stability of active ingredients.

Abstract: A reverse electrodialysis device using a precipitation reaction, according to one embodiment of the present invention, comprises a first cell stack alternately forming solid salt chambers and precipitation chambers through cation-exchange membranes and anion-exchange membranes which are alternately provided, and a first water-soluble solid salt and a second water-soluble solid salt which are filled in the solid salt chambers, wherein the first water-soluble solid salt and the second water-soluble solid salt are alternately filled in the solid salt chambers, and can react with each other so as to generate a precipitate in neighboring precipitation chambers when water is supplied.

Abstract: A method of targeting to the synovial tissue biodegradable drug delivery compositions or morselizing biodegradable drug delivery compositions are described. The biodegradable drug composition comprises a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as at least one pharmaceutically active principle is disclosed.

Abstract: A flowpack for oral delivery of active ingredients comprises a population of particles and one or more active ingredients, the population of particles including at least two types of sugar alcohol particles, wherein at least one of said two types of sugar alcohol particles comprises granulated sugar alcohol particles.

Abstract: In the microsphere preparation for chemoembolization therapy and nuclear medicine imaging of tumor, and a preparation method thereof, the microsphere is formed by means of using a polyvinyl alcohol derivative as a framework material and polymerizing, crosslinking and curing same with an N-acryl amino acid monomer. The microsphere can label radionuclide iodine and can also absorb load chemotherapeutic drugs.

Abstract: A bone substitute composition includes a bone substitute matrix and a conditioning solution. The bone substitute matrix includes 85% to 98% by weight of alkaline calcium phosphate powder, 1% to 10% by weight of a polymer, and 1% to 5% by weight of a crosslinker. The conditioning solution includes 90% to 97% by weight of water, 1% to 5% by weight of a phosphate, and 1% to 5% by weight of a water-soluble acidic compound.

Abstract: Compositions providing a once-a-night dose of oxybate are provided. The compositions containing bilayer-coated oxybate anion exchange resin complex multiparticulates provide modified release of the oxybate for 5 to 8 hours post-dosing. Also provided are methods of treating patients in need thereof with pharmaceutical compositions containing the oxybate—anion exchange resin complex.

Abstract: The present invention provides a pharmaceutical article that includes a container and a dilute aqueous PVP-I formulation contained in the container, wherein the container is made of polyethylene terephthalate (PET) or polypropylene (PP). The pharmaceutical article provides the aqueous PVP-I formulation with surprisingly enhanced stability over PVP-I-formulations in other pharmaceutical package forms, without the need of a stabilizing agent in the PVP-I formulations.

Abstract: Drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least one drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the drug entrapped therein for at least about 3 hours.

Abstract: Polymers comprising a plurality of cannabinoids, methods of preparation thereof, and methods of use to treat a number of disease conditions are reported. Also provided are polymer coatings, films, fibers, and non-woven fabrics for a variety of topical applications including stents, bandages, sutures, and transdermal patches.

Abstract: Antiperspirant/deodorant compositions are described. Said antiperspirant/deodorant compositions comprise, in a cosmetically acceptable medium, (a) at least one cosmetic ingredient obtained from Bamboo, (b) at least one cosmetic ingredient obtained from Maranta arundinaceae (Arrowroot); and (c) at least one natural starch. These antiperspirant/deodorant compositions are useful in reducing body odor and in wetness absorption. A method for the cosmetic treatment of body odors, in particular axillary odors, which includes applying, to the skin, in particular the axillae, these compositions is also described.

Abstract: Primarily aimed at providing a novel pharmaceutical composition. The present invention relates to a pharmaceutical composition that contains a cerium compound as an active ingredient.