Patents Examined by William E. Benston
  • Patent number: 6337082
    Abstract: The present invention is a saccharide-bsed matrix and the product resulting therefrom made from a maltodextrin feedstock subjected to conditions which induce flash flow of the maltodextrin so that the matrix possesses a physically- or chemically-altered structure from the feedstock. The present invention also includes a method of producing the matrix and of making products which take advantage of the unique properties of the matrix. Such products include, but are not limited to, unique colloidal-like dispersions and suspensions made from the matrix.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: January 8, 2002
    Inventors: Richard C. Fuisz, Robert K. Yang
  • Patent number: 6248362
    Abstract: A process for delivering the orally administered active ingredients which are safe even in their successive administrations for a long period to the large intestine without elution of the ingredients before reaching the large intestine is disclosed. The process according to the present invention comprises a step of administering orally to animals including human a composite comprising a core containing the active ingredients, an internal layer comprising chitosan with which the core is coated, and an external layer comprising a gastric acid resistant material with which the internal layer is coated, wherein all of the materials in the composite have the empirically established safety to humans. When a material having an iron cation scavenging ability, particularly phytin is used as the active ingredient, it is possible to treat colon cancer efficiently by the process according to the present invention.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: June 19, 2001
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Shigeru Tominaga, Toshio Takizawa, Masahiko Yamada
  • Patent number: 6245359
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 12, 2001
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B Santiago
  • Patent number: 6214382
    Abstract: This invention provides a hydrophilic membrane wherein a hydrophilic cellulose derivative of a number average molecular weight of 2000˜8000 is adsorbed irreversibly to a hydrophobic membrane of an aromatic polymer. Since an amount of leaching substances is extremely small, the membrane can be used suitably in such fields as medical applications, electronics, etc. where even a quite small quantity of leaching substances from the membranes is limited especially small.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: April 10, 2001
    Inventors: Tamiyuki Eguchi, Kiyoshi Ando, Yasuo Shimizu
  • Patent number: 6214384
    Abstract: Microspheres, having a size lower than 1&mgr; and comprising a biocompatible polysaccharidic polymer, are prepared with a process comprising the precipitation of polymer induced by means of a supercritical antisolvent (SAS). These microspheres are used as vehicling agents or carriers in the preparation of pharmaceutical compositions administrable by oral, nasal, pulmonary, vaginal or rectal route. These microspheres can also be advantageously used as vehicling agent or carriers in the preparation of pharmaceutical compositions for the treatment of human diseases associated with genic defects, for the preparation of diagnostics and in the agro-alimentary industry.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: April 10, 2001
    Assignee: Fidia Advanced Biopolymers S.r.l.
    Inventors: Paolo Pallado, Luca Benedetti, Lanfranco Callegaro
  • Patent number: 6197343
    Abstract: The invention relates to a complexion-improving beauty composition comprising disintegrable granules and a blood circulation accelerator. The composition can synergistically exhibit a blood circulation-accelerating effect in a short period of time, is excellent in the effect of improving a complexion, and does not irritate the skin and eyes, thus being highly safe.
    Type: Grant
    Filed: October 1, 1998
    Date of Patent: March 6, 2001
    Assignee: Kao Corporation
    Inventors: Takahide Minami, Akiko Suzuki, Hidetaka Iwai, Yukihiro Yada, Yoshinao Nagashima
  • Patent number: 6183782
    Abstract: The present invention relates to a pharmaceutical composition which is suitable for the administration of medicaments by inhalation. In particular, the pharmaceutical composition comprises microfine particles of medicament and at least one lactose pellet having a diameter of from about 10 to about 1500 micrometers, which pellet comprises a plurality of microfine lactose particles. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of medicament selected from the group consisting of anti-allergics, bronchodilators, anti-inflammatory steroids and mixtures thereof in the pharmaceutical composition as defined is also described.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: February 6, 2001
    Assignee: Glaxo Group Limited
    Inventor: Gerald Wynn Hallworth
  • Patent number: 6180141
    Abstract: The invention relates to vectors for delivering medicinal, nutritional, plant-protection or cosmetic active principles, these delivery particles being of small, controllable and adjustable particle size, which protect the active principle, and being biocompatible, biodegradable, non-immunogenic, stable and free of solvent. The particles do not denature the active principle and allow the active principle to be released. The microparticles of the invention are of a cohesive structure made of a physicochemically stable and integral composite gel which includes an oil such as coconut oil, an aqueous phase and a linear, non-crosslinked copolyamino acid of Leu/Glu type (random or diblock). The microparticles have a controllable and adjustable size of between 0.05 and 500 &mgr;m.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: January 30, 2001
    Assignee: Flamel Technologies
    Inventors: Alain Lemercier, R{acute over (e)}mi Meyrueix, Sylvain Huille, G{acute over (e)}rard Soula
  • Patent number: 6165511
    Abstract: A polyol composition useful for the production of tablets for consumption. The polyol is obtained by co-spray drying or co-fluidized bed granulating at least two polyols, one of which is a non-hygroscopic polyol, and the non-hygroscopic polyol is present in an amount of at least 80% by weight. An optional binder may be present. An active medicament may be present.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: December 26, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Eugen Schwarz, Gernot Moschl, Karin Maul
  • Patent number: 6165510
    Abstract: A cosmetic composition includes an inorganic material in granular form which, under condition of use of the cosmetic composition, breaks down to a particle size wherein less than 5% by weight, preferably less than 2% by weight, most preferably less than 1% by weight is above 45 microns, as measured by wet sieve analysis.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: December 26, 2000
    Assignee: Crossfield Limited
    Inventors: Pamela Baines, Peter William Stanier
  • Patent number: 6162463
    Abstract: An extended release formulation of diltiazem which is suitable for once-daily oral administration comprises a quantity of a quick release preparation of diltiazem or a pharmaceutically active salt thereof, mixed with a quantity of a slow release (or delayed release) preparation of diltiazem or a pharmaceutically active salt thereof. The quick release preparation used obtains a maximal release of diltiazem within approximately 1-2 hours after administration, and then falls toward baseline levels. The delayed release preparation individually shows a maximal release of diltiazem at between approximately 6-8 hours after administration.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: December 19, 2000
    Inventor: Arnold S. Lippa
  • Patent number: 6156320
    Abstract: Methods for treating or preventing diseases or conditions, which are associated with or caused or contributed to by an opportunistic or pathogenic microorganism in a subject, comprising administering to the subject an effective amount of a culture of lactic acid fermentation microorganisms of the species Lactobacillus acidophilus are disclosed.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: December 5, 2000
    Assignee: Harry Parsekian
    Inventors: Tamara Georgievna Izvekova, Alexandr Viktorovich Kornilov, Irina Surenovna Amirian
  • Patent number: 6149941
    Abstract: The invention relates to a process for improving the taste of solid formulations containing one or more active ingredients.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: November 21, 2000
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Eugen Schwarz, Gernot Moschl, Siva Tallavajhala
  • Patent number: 6149932
    Abstract: A dietary supplement for humans and hair-bearing pets such as dogs and cats, comprising safflower oil, sunflower oil, olive oil, soya oil, cod liver oil, lecithin, natural flavors, herbs, garlic, and zinc. When fed to a dog or cat daily in a proper dosage, the supplement reduces or eliminates non-seasonal shedding and promotes healthy skin and a glossy coat, silky coat, without affecting the dog's or cat's natural shedding cycle and without causing any harmful effects. The composition also may be administered topically to a human to reduce hair loss.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: November 21, 2000
    Assignee: Stabar Enterprises, Inc.
    Inventor: Barabra A. Allen
  • Patent number: 6146664
    Abstract: An ascorbic acid (Vitamin C) composition in a nonaqueous or substantially anhydrous silicone vehicle has superior stability. Particulate ascorbic acid is substantially insoluble in the disclosed polyorganosiloxane vehicles, and the vehicle substantially excludes environmental oxygen. The ascorbic acid particles have surprisingly been found to have a high degree of bioavailability and effectiveness, for example in topical applications to reduce wrinkles and increase collagen growth and elasticity.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: November 14, 2000
    Assignee: Shaklee Corporation
    Inventor: Mukhtar Siddiqui
  • Patent number: 6139870
    Abstract: Stabilized nanoparticles capable of being filtered under sterile conditions and including at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) emulsified in a solution of phospholipids and an oleic acid salt.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: October 31, 2000
    Assignee: Aventis Pharma SA
    Inventor: Thierry Verrecchia
  • Patent number: 6132772
    Abstract: The present invention relates to extended-release solid oral dosage forms of a drug having low solubility in water are obtained by dissolving the drug in polyethylene glycol having a mean molecular weight of at least 1000 and adding thereto a hydrophilic gel-forming polymer.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: October 17, 2000
    Inventor: Bernard Charles Sherman
  • Patent number: 6132737
    Abstract: A method for reducing the formation of sunburn cells in mammalian skin exposed to ultraviolet radiation, comprising applying a cosmetic composition containing stabilized ascorbic acid to the the skin prior to exposure to ultraviolet radiation.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: October 17, 2000
    Assignee: Revlon Consumer Products Corporation
    Inventors: Barbara Ann Wolf, Patricia Beatrice Siuta
  • Patent number: 6123964
    Abstract: The present invention relates to a pharmaceutical composition and a process for the preparation of a tablet containing a growth hormone secretagogue as the active ingredient. The tablet is prepared by forming a powder blend of the active ingredient N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, or a pharmaceutically acceptable salt thereof, in particular the methanesulfonate salt, with a binder/diluent, a first diluent, a second diluent, a first portion of a disintegrant, and a lubricant; wet granulating the powder blend with a solution of ethanol/water to form granules; drying the granules to remove the ethanol/water; adding a second portion of a disintegrant; lubricating the granules; and compressing the dried granules into the desired tablet form.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: September 26, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Mandana Asgharnejad, Jerome Draper, David Dubost, Michael Kaufman, David Storey
  • Patent number: 6120787
    Abstract: A method of preparing parenterally administrable sustained release microparticles, which comprises preparing core particles in an aqueous medium that is essentially free from organic solvent, a biologically active substance being entrapped therein during or after said preparation, drying the core particles and coating the same with a release-controlling polymer by air suspension technique so as to create a shell on the core particles without any detrimental exposure of the active substance to organic solvent. Microparticles obtainable by such a method also are provided.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: September 19, 2000
    Assignee: Biogram AB
    Inventors: Nils-Ove Gustafsson, Timo Laakso, Peter Fyhr, Monica Jonsson