Abstract: Stabilized nanoparticles capable of being filtered under sterile conditions and including at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) emulsified in a solution of phospholipids and an oleic acid salt.

Abstract: The present invention describes the use of croscarmellose sodium to coat bitter-tasting active agents in a manner that will mask the bitter taste of these materials, taste masked pharmaceutical compositions in which the particles of pharmaceutically active agent are coated with croscarmellose sodium, taste masked pharmaceutical tablets made therefrom, in which the rapid disintegration of tablets that is imparted by croscarmellose sodium is preserved, and to a method for preparing such coated particles by preparing them in a fluidized bed coating process.

Abstract: The present invention relates to moisture absorbing body powder compositions. Through careful formulation of the powder carrier, the present invention also provides moisture absorbing body powders with surprisingly good skin feel characteristics. The powder carrier which provides the good skin feel characteristics comprises skin feel components selected from the group consisting of: starch, metallic stearates, fatty acid derivatives, nylon, polyethylene, polytetrafluoroethylene, and platelet-shaped powders.

Abstract: A dry powder that contains carotenoids produced by grinding a mixture of carotenoids and oil to reduce the carotenoid particle size, emulsifying the mixture with an encapsulating mixture, and drying the emulsification. The encapsulating mixture includes a starch encapsulating agent, a sugar, and an anti-oxidant. The resulting water-dispersible powder contains a high concentration of carotenoids, yet is protected from oxidation.

Abstract: Preparation method for preparing a therapeutical composition for internal use, particularly to be administered by mouth, in galenical presentation, and containing at least one active principle in solid form adsorbed on a substrate, the active product being distributed therein as finely dispersed microparticles. The method includes dissolving the starting active principle in an appropriate solvent, impregnating the solution thus formed on a food support having an appropriate structure and pharmaceutically compatible with the active principle, and evaporating the solvent from the solution adsorbed in the support by causing the reconstitution of the active principle by formation of microcrystals adsorbed on the walls of the substrate and within the substrate. The solvent is comprised of a binary system including a main solvent of organic nature and an adjuvent of the solid type at room temperature and soluble in the main solvent. The adjuvent additionally has lubricating properties.

Abstract: There is provided a pharmaceutically acceptable taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of polyethylene glycol and cellulosic material.

Abstract: Disclosed is an improved method of extracting neem seeds. The method involves co-solvent extracting neem seeds with a solvent mixture of a nonpolar, aliphatic hydrocarbon solvent and a polar solvent to simultaneously remove the hydrophilic and hydrophobic extracts from the neem seeds. The method provides novel neem extract mixtures which contain both the hydrophobic and hydrophilic portion of the neem seeds. The extract mixtures may be further extracted to yield an azadirachtin-containing solid product having greater than 10 weight percent of azadirachtin.

Abstract: Microcapsules containing at least one sun filter having been hardened so as to be impervious with a size of 1 to 1250 micrometers whereby the sun filters do not come in contact with the skin.

Abstract: A sustained release tablet adapted to provide an initial immediate release of an active agent, a period of no release of the active agent, followed by a substantially constant, rate of release of the active agent. The tablet includes (a) a compressed tablet core containing an active agent, an insoluble binder and an insoluble; (b) a barrier coating formed over the tablet core, the barrier coating including a mixture of soluble and insoluble polymers and a plasticizer; (c) an active coating deposited over the barrier coating, the active coating including an active agent, a soluble polymer and a plasticizer; and (d) a film coating formed over the active coating, the film coating containing a soluble polymer and plasticizer.

Abstract: A three component system and method for whitening teeth comprising a pre-conditioning mouth rinse, a bleaching gel, and a polishing and pigmenting paste wherein each component is applied to the teeth independently and in sequential order.

Abstract: Disclosed is a process of preparing granules involving first preparing a carrier comprising diluent, binder, and optionally a disintegrating agent. In a container separate from said carrier, asteroid, lubricant and, optionally, an antioxidant are dissolved in an, optionally pre-heated, organic solvent. The resulting solution is added to the carrier contained within an, e.g. vacuum mixer, followed by further blending of the mixture. The organic solvent is removed from the mixture. The mixture is blended further to form granules. The process may further include incorporating a flow enhancer such as colloidal silicon dioxide into the granules. A granule for making a pharmaceutical dosage unit is granule characterized in comprising: a) a carrier comprising diluent and binder, and b) a film coating said carrier, said film comprising desogestrel and a lubricant, and has the characteristic of by retaining 90% of the desogestrel at a pressure of 150 mbar and at a temperature of 70.degree. C. over 72 hours.

Abstract: An aqueous solution or dispersion for oral intake of at least two different pharmaceutical active substances is prepared by dissolving or suspending at least two different effervescent, soluble and/or disintegrating mixtures in tablet or granule form, each of which contains a different active substance or a different active substance combination, in one and the same quantity of water. At least one of the tablets may be used only as a fragment, and at least one of the mixtures may weigh less than 2000 mg, preferably less than 1500 mg, in particular less than 1000 mg. In particular at least one of the mixtures contains diuretic, in particular hydrochlorothiazide and/or furosemide, and at least one of the further mixtures contains a beta-blocker and/or a vasodilator, in particular naftidrofuryl, calcium antagonist, ACE inhibitor or alpha-1-blocker. Such effervescent, soluble and/or disintegrating mixtures in tablet or granule form are preferably used for the treatment of hypertension.

Abstract: Pharmaceutical formulations for oral administration coated by an enterosoluble gastroresistant film, preferably selected from gastroresistant granulates, gastroresistant tablets, gastroresistant hard gelatine capsules containing powders or granulates or two or more tablets or oily suspensions, gastroresistant soft gelatine capsules containing oily suspensions and hard gelatine capsules containing gastroresistant granulates or two or more gastroresistant tablets, containing therapeutically effective amounts of bile acids mixed with physiologically compatible basic substances which favor bile acids salification and therefore bile acids absorption in the intestinal tract, process for their preparation and therapeutic use thereof in the treatment of biliary calculoses, biliary dyspepsias, biliary cirrhosis and chronic and cholestatic hepatopathies.

Abstract: A novel fungicide derived from a neem seed extract comprising neem oil which is substantially free of azadirachtin, said neem oil being prepared by extracting dried, coarsely ground neem seeds with a non-polar, hydrophobic solvent to obtain a neem oil extract, and then removing the solvent to obtain the neem oil. These neem oil fungicides exhibit the ability to control various fungi.

Abstract: There is disclosed a hair cleansing composition having excellent detergency against oily dirts such as aged high-viscosity silicone compounds. The composition comprises the following components (a) to (d):(a) : 0.05 to 15% by weight of a surfactant,(b) : 0.5 to 40% by weight of an alcohol,(c) : 0.1 to 25% by weight of water, and(d) : 20 to 98% by weight of a liquid oil,wherein a viscosity ratio of a mixture of the components (a) to (c) to a mixture of oil components comprising component (d) is 1 or more.

Abstract: The invention disclosed comprises apparatus in the nature of resiliently flexible laminated pads, with or without magnetic tape, used to apply pressure to various areas of a human body, particularly the back, to alleviate back pain and related symptoms due to muscle strain, tension or nerve irritation, as well as headaches and menstrual discomfort.

Abstract: A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.

Abstract: A free-flowing, fine white powder of a substantially aqueous stable complex of a strongly swellable, moderately crosslinked polyvinylpyrrolidone (PVP) having an aqueous gel volume of about 15 to 150 ml/g of PVP and a Brookfield viscosity in 5% aqueous solution of at least about 10,000 cps, and H.sub.2 O.sub.2, in substantially a 1:1 molar ratio of said constituents.

Abstract: The present invention relates to a device for the topical and systemic administration of active substances to or through the skin consisting of a backing layer, at least one self-adhesive layer, and a removable protective layer, wherein the self-adhesive layer consists of(a) 100 parts by weight of a polyacrylate adhesive,(b) 5 to 150, preferably 10 to 100, and in particular 15 to 50 parts by weight of a film former compatible with polyacrylates,(c) 0 to 250 parts by weight of a non-softening active substance and/or adjuvant, and(d) 10 to 250 parts by weight of a softening active substance and/or adjuvant.

Abstract: Controlled release pharmaceutical formulations for oral administration coated by an enterosoluble gastroresistant film, preferably selected from gastroresistant granulates, gastroresistant tablets, gastroresistant hard gelatine capsules containing powders or granulates or two or more tablets or oily suspensions, gastroresistant soft gelatine capsules containing oily suspensions and hard gelatine capsules containing gastroresistant granulates or two or more gastroresistant tablets, containing therapeutically effective amounts of a mixture of bile acids and their salts with alkali metals or organic bases, process for their preparation and therapeutic use thereof in the treatment of biliary calculoses, biliary dyspepsias, biliary cirrhosis and chronic and cholestatic hepatopathies.