Abstract: Pulverulent compounds of outstanding thermal stability and solvent resistance are provided which are based on epoxy resins having more than one 1,2-epoxide group and one or more hydroxyl groups in the resin molecular chain, curing agents and optionally, one or more conventional auxiliaries and additives, wherein the curing agents contain one or more polyisocyanates which are blocked with inert blocking agents and with cyclic amidines of the general formulae I and/or II ##STR1## wherein R is as described herein, at an OH:NCO ratio of from 1 -0.1 to 1:1, the content of cyclic amidine in bound form is from 2 to 9% by mass, based on the epoxy resin employed, and the hardener contains from 0.9 to 0.3 mol of inert blocking agents and from 0.1 to 0.6 mol of cyclic amidines per NCO group, the preparation of these pulverulent compounds and their use as one-component adhesives.

Abstract: The present invention relates to a process for the preparation of spherical or substantially spherical, practically dust-free aromatic and odoriferous granulated material which is free-flowing, mechanically stable and has a narrow grain-size distribution.

Abstract: Disclosed is a process for the preparation of pharmaceutical dosage units containing as an active substance of from 0.005 to 1.0% by weight of micronised Org 30659, comprising (a) a mixing step comprising bringing into association the active substance and a suitable carrier to form a mixture, and (b) a granulating step in which the mixture is granulated to form agglomerates or granules by wetting the mixture with a binder liquid, the wetting being conducted under agitation, characterised in that the granulation step (b) is conducted so as to exert on the granules a shear force which does not exceed the tensile strength of the agglomerates or granules. The process leads to granules and tablets having an excellent content/uniformity.

Abstract: A method for preparing .beta.-sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.

Abstract: The invention relates to a method for the treatment or prevention of hypoperfusions of abdominal organs comprising administering a gaseous medication containing nitrogen monoxide and carbon dioxide to the patient. The gaseous medication is administered by the intra-abdominal route.

Abstract: The present invention relates to an antimicrobial pigment, its production process, and a cosmetic composition containing the pigment. More particularly, it relates to an antimicrobial cosmetic pigment produced by forming an amorphous glassy inorganic coating layer of metal oxides over the surface of inorganic cosmetic pigment and intercalating antimicrobial metals inside the lattice structure of the coating layer, it's production process, and a cosmetic composition containing it. Silica, either alone or as the principal ingredient in combination with one or more oxides selected from the group consisting of zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, lithium oxide, sodium oxide, potassium oxide, and ferric oxide is utilized as the metal oxide and the composition utilizes silver, copper and zinc as the antimicrobial metals.

Abstract: A bolus for delivery of pulsed doses of biologically active material to a ruminant comprises a series of distinct and separate bolus elements. Each bolus element is constructed of a degradable outer sheath and a core of biologically active material. The elements are adapted to separate following administration to the ruminant, and to disperse in the rumeno-reticular sac. In due course the elements degrade or corrode to release the biologically active material. Example boli include bolus elements of different respective corrosion characteristics and, as such, are capable of releasing pulsed doses of the active material to the ruminant.

Abstract: The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a film-forming polymer derivative, a hydrophobic plasticizer, a functional agent and a nitrogen-containing polymer. These microcapsules are also characterized by their ability to remain in the small intestine for a long time (at least 5 hours) and to allow, during the residence, release and absorption of the AP. The invention also relates to a process for the production of the said microcapsules.

Abstract: The present invention relates to a method for making spray-dried tablettable powders with high edible oil loadings based on non-hydrolyzed gelatin. Said edible oils can be vitamin, flavor and fragrance oils.

Abstract: The hair treatment composition includes (A) at least one polydimethylsiloxane with hydroxy end groups, advantageously .alpha.-hydroxy-.omega.-hydroxy-poly[oxy(dimethylsilylene)]; (B) at least one volatile, linear or cyclic polydimethylsiloxane, advantageously octamethylcyclotetrasiloxane, and (C) at least one isoparaffin, advantageously an isomeric mixture of isododecanes. Also the composition is advantageously free of water or contains no more than 5 % water and is free of cross-linking agents. The composition forms a smooth protective film on hair which is treated with it, with brilliant luster, without loading the hair.

Abstract: A non-toxic edible enteric film coating dry powder composition for use in making an aqueous enteric coating suspension which may be used in coating pharmaceutical tablets and the like comprises an enteric film forming polymer, a detackifier, a viscosity modifier, and an alkalizing/anti-coagulating agent. Advantageously, the inventive dry powder compositions may include a solid plasticizer, a lubricant, an anti-caking agent, a liquid plasticizer, and a pigment.

Abstract: The invention relates to a tabletting excipient based on disintegrated starch granules, which is characterized by a content of long-chain amylose of at least 10% by weight based on the dry substance, a cold water-solubility of at most 25% by weight and a specific area of at least 1 m.sup.2 /g. The invention further relates to a method for preparing such tabletting excipient and to the use of the tabletting excipient in tablets.

Abstract: The analgesic effectiveness of a narcotic agonist-antagonist analgesic is significantly potentiated by administering a narcotic agonist-antagonist analgesic together with at least one nontoxic NMDA receptor antagonist.

Abstract: Invented is a novel pharmaceutical composition containing Paroxetine.

Abstract: A powder formulation for the administration of medically useful polypeptides, comprising a medically useful polypeptide with melezitose as diluent.

Abstract: A composition and method which increases the bioavailability of ingested Ginkgo Biloba extract (GBE). The composition comprises a mixture of polyol(s), and GBE. The composition is ingested, either in the concentrated paste form, diluted with edible liquid or food as an additive. Increased serum levels of gingolide A, B and bilobalide are demonstrated for individuals ingesting the composition over ingesting GBE without the polyol(s).

Abstract: A biomaterial composition for the resorption/substitution of organic supporting tissues, including 20-75 wt. % of an inorganic phase consisting of particles that include either hydroxyapatite (A) optionally mixed with tricalcium phosphate .beta. (B), or calcium-titaniumphosphate (Ca(Ti).sub.4 (PO.sub.4).sub.6) (C), and 80-25 wt. % of a liquid phase including an aqueous solution of a water-soluble biocompatible polymer that is cross-linkable under the effect of the pH of the medium. The composition is sterilizable, injectable and curable in biological media to form a biomaterial for replacing supporting tissues.

Abstract: In accordance with the present invention, there are provided stabilized total nutrient admixture (TNA) compositions which are useful for the in vivo parenteral delivery of pharmacologically acceptable lipids or fats, as well as methods for the preparation thereof. In particular, the pharmacologically acceptable lipid or fat is contained within a protein walled shell. In a particular embodiment of the invention, a TNA composition using human serum albumin (HSA) as a stabilizer has been prepared as a convenient three-in-one formulation (i.e., containing a fat emulsion, dextrose, and amino acids plus electrolytes). This "three-in-one" formulation can be prepared in liquid form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation). This serves to rehydrate the powder into a TNA suitable for injection.

Abstract: A dermatitis-curing agent, characterized by comprising (A) a zinc compound and (B) at least one compound selected from the group consisting of multivalent unsaturated fatty acids and their esters as effective components is very effective for enteropathic acrodermatitis syndrome, and seborrheic dermatitis, psoriasis vulgaris, bullous dermatitis and puritus cutaneus, which show similar skin symptoms, or for symtoms due to zinc deficiency caused by injuries, burn injuries and frostbites.

Abstract: Microspheres prepared by emulsifying an aqueous phase containing a drug and an oil phase containing a biodegradable polymer to form a W/O emulsion, and then mixing and agitating this emulsion with another aqueous phase constituting a continuous phase to form a W/O/W emulsion. These microspheres can release a major portion of the drug after a predetermined period of time has elapsed after their administration to the patient, and are especially suitable for intracerebral implantation.