Abstract: The present invention includes systems, devices and methods for treating and/or diagnosing a heart arrhythmia, such as atrial fibrillation. Specifically, the present invention provides a system including a diagnostic catheter and an ablation catheter. The diagnostic catheter includes a shaft, multiple dipole mapping electrodes and multiple ultrasound transducers. The ablation catheter is slidingly received by the diagnostic catheter shaft.

Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.

Abstract: A medical electrical stimulator provides selective control of stimulation via a combination of two or more electrodes coupled to respective regulated current paths and one or more electrodes coupled to unregulated current paths. Constant current sources may control the current that is sourced or sunk via respective regulated current paths. An unregulated current path may sink or source current to and from an unregulated voltage source that serves as a reference voltage. Unregulated electrodes may function as unregulated anodes to source current from a reference voltage or unregulated cathodes to sink current to a reference voltage.

Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.

Abstract: Implantable medical leads and implantable lead extensions include a shield. The implantable medical lead is coupled to the implantable lead extension. Stimulation electrodes of the implantable medical lead contact stimulation connectors within a housing of the implantable extension to establish a conductive pathway for stimulation signals from filars of the implantable extension to filars of the implantable medical lead. Continuity is established between the shield of the implantable medical lead and the implantable extension by providing a radio frequency conductive pathway within the housing. The radio frequency conductive pathway extends from a shield of the implantable extension to a shield connector that contacts a shield electrode of the implantable medical lead. The radio frequency conductive pathway may have various forms such as a jumper wire or an extension of the shield within the implantable extension.

Abstract: Disclosed in an improved medical implantable device system including an improved external charger that is able to communicate with an external controller and IPG using the communication protocol (e.g., FSK) used to implement communications between the external controller and the implant. The external controller as modified uses its charging coil to charge the implant, and also to communicate with the other devices in the system. As such, the external charger is provided with transceiver circuitry operating in accordance with the protocol, and also includes tuning circuitry to tune the coil as necessary for communications or charging. Communication or charging access to the charging coil in the external charger is time multiplexed. The disclosed system allows charging information to be provided to the user interface of the external controller so that it can be reviewed by the user, who may take corrective action if necessary.

Abstract: Methods to identify and risk stratify disease states, cardiac structural defects, functional cardiac deficiencies induced by teratogens and other toxic agents, pathological substrates, conduction delays and defects, and ejection fraction using single channel biological data obtained from the subject. A modified Matching Pursuit (MP) algorithm may be used to find a noiseless model of the data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to characterize the cardiac system. In another method, space-time domain is divided into a number of regions (which is largely determined by the signal length), the density of the signal is computed in each region and input to a learning algorithm to associate them to the desired cardiac dysfunction indicator target.

Abstract: Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (LCP) that is implanted within or proximate the heart. From this location, the LCP may provide pacing therapy to the heart based at least in part on the sensed cardiac electrical data. An implantable medical device located remotely from the heart may sense patient activity, and may wirelessly communicate patient activity data from the implantable medical device to the LCP, sometimes using conducted communication. The LCP may be then determine an adjustment to the provided pacing therapy (e.g. adjust the pacing rate) based at least in part on the received patient activity data signal.

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Abstract: Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.

Abstract: A biological information processing system includes a pulse wave information acquisition unit which acquires pulse wave information of a user, and a processing unit which determines the sleep state of the user based on the pulse wave information. The processing unit obtains index information relating to an arousal state during sleep based on the pulse wave information.

Abstract: A camera coupled to a processor is disclosed. The camera is configured to capture images of the subject. The processor is configured to amplify microscopic temporal variations between the images of the subject and generate a profile of at least one microscopic temporally detected physiological variation of the subject. The processor is further configured to compare the profile of the subject to a pre-existing first aggregate profile of a plurality of third-party subjects, said aggregate profile corresponding to the at least one microscopic temporally detected physiological variation of the third-party subjects, the aggregate third-party profile corresponding to a known state of the third-party subjects.

Abstract: A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.

Abstract: An automated external defibrillator (AED) is described which spends an increased proportion of a rescue in a CPR mode. This is accomplished by use of a single shock protocol which causes the AED to spend less time in shock analysis and delivery activities as compared with the typical multiple shock protocol. An AED of the present invention preferably is configured such that the rescue protocol can be modified or changed easily without the need to remove the battery or use specialized hardware or software. Preferably the shock waveform of the single shock is a biphasic waveform delivering at least 150 Joules of energy and more preferably at least 200 Joules of energy.

Abstract: The electrosurgical systems and methods of the present disclosure perform cable compensation using an electrosurgical generator that includes a plurality of sensors configured to sense voltage and current waveforms, a plurality of medium-band filters, a plurality of narrowband filters, and a signal processor. The plurality of medium-band filters and narrowband filters pass sensed voltage and current waveforms at a plurality of predetermined frequencies. The signal processor calculates medium-band RMS voltage and current values using the output from the plurality of medium-band filters, calculates narrowband phase and magnitude values using the output from the plurality of narrowband filters, calculates tissue impedance based on the medium-band RMS voltage and current values and the narrowband phase value, and generates a control signal to control the energy generated by the electrosurgical generator based on the calculated tissue impedance.

Abstract: The electrosurgical systems and methods of the present disclosure perform cable compensation using an electrosurgical generator that includes a plurality of sensors configured to sense voltage and current waveforms, a plurality of medium-band filters, a plurality of narrowband filters, and a signal processor. The plurality of medium-band filters and narrowband filters pass sensed voltage and current waveforms at a plurality of predetermined frequencies. The signal processor calculates medium-band RMS voltage and current values using the output from the plurality of medium-band filters, calculates narrowband phase and magnitude values using the output from the plurality of narrowband filters, calculates tissue impedance based on the medium-band RMS voltage and current values and the narrowband phase value, and generates a control signal to control the energy generated by the electrosurgical generator based on the calculated tissue impedance.

Abstract: A signal processing system is described for a hearing implant system. A band pass filter bank processes an audio input signal to generate band pass signals. An implant signal processor processes the band pass signals to generate electrode stimulation signals. The processing includes: i. monitoring a key feature characteristic of the audio input signal, ii. using an original coding strategy to generate the electrode stimulation signals when the key feature is less than or equal to an initial value, and iii. using a different new coding strategy to generate the electrode stimulation signals when the key feature is greater than or equal to a coding change value. The implant signal processor automatically transitions from the original coding strategy to the new coding strategy over a transition period of time by adaptively changing the original coding strategy to become the new coding strategy.

Abstract: The present invention is related to an implantable medical device. The medical device comprises an implantable component having a receiver unit; an external charging module having a power transmitter unit; and a data module having a data transmitter unit. The units are configured to establish a transcutaneous communication link over which data and power is transmitted on a single frequency channel via a time interleaving scheme comprising successive frames each divided into at least two time slots, and wherein one or more of the time slots in each frame is allocated to the data transmitter unit, and wherein one or more of the time slots in each frame is allocated to the power transmitter unit, and wherein data and power are transmitted by the transmitter units during their allotted time slots.

Abstract: Bipolar electrosurgical devices may include a handle assembly configured to control movement of components of the electrosurgical device to perform an electrosurgical procedure and a power cord assembly configured to electrically connect the bipolar electrosurgical device with a power source. For bipolar sphincterotomes, an active portion of the handle assembly may include a first active member that contacts and slides across a second active member as the gripping portion moves about a handle stem component of the handle assembly. The power cord assembly may include a pair of return contacts that are shorted together when connected with the handle assembly, which in turn may deactivate an alarm output by the power source.

Abstract: A system and method for catheter placement using ECG is provided. In certain embodiments, the system and method can generate a patient specific window for tracking a characteristic of an ECG waveform, such as the amplitude of a P-wave. The patient specific window can be utilized in a system and method for assisting in the placement of a catheter within a patient. In other embodiments, a tip location algorithm can be used with an anti-thrombogenic catheter and an intravascular electrode assembly for maintaining a high resolution intravascular signal in an ECG based catheter tip placement system.