Patents Examined by Wu-Cheng Winston Shen
  • Fused ring analogues of anti-fibrotic agents
    Patent number: 9062076
    Abstract: The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: June 23, 2015
    Assignee: Fibrotech Therapeutics PTY LTD
    Inventors: Spencer John Williams, Steven Zammit, Darren James Kelly
  • Liquid ganaxolone formulations and methods for the making and use thereof
    Patent number: 9056116
    Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: June 16, 2015
    Assignee: Marinus Pharmaceuticals
    Inventors: Kenneth Shaw, Mingbao Zhang
  • Bridged heterocyclic compounds and methods of use
    Patent number: 9051314
    Abstract: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: June 9, 2015
    Assignee: Medivation Technologies, Inc.
    Inventors: David T. Hung, Andrew Asher Protter, Sarvajit Chakravarty, Rajendra Parasmal Jain
  • Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient
    Patent number: 9045423
    Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: June 2, 2015
    Assignee: KOWA COMPANY, LTD.
    Inventors: Masanori Ashikawa, Junya Tagashira, Akiyasu Koketsu, Toshiharu Morimoto, Takahiro Kitamura, Syunji Takemura, Gen Watanabe, Tatsuaki Nishiyama, Satoshi Goda, Masaki Yamabi, Takeshi Doi, Hiroyuki Ishiwata
  • 7,11-methanocycloocta [B] quinoline derivative as highly functionalizable acetylcholinesterase inhibitors
    Patent number: 9040506
    Abstract: New highly functionalizable Huprine derivatives of formula I: and a method for preparing such compounds and their use for treating neurological diseases in which the level of acetylcholine is affected such as Alzheimer's disease.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: May 26, 2015
    Assignee: UNIVERSITE DE ROUEN
    Inventors: Cyril Ronco, Pierre Yves Renard, Ludovic Jean, Florian Nachon, Anthony Romieu
  • Water-insoluble reaction product of a polyamine and an oil-soluble high carbon polar modified polymer
    Patent number: 9040593
    Abstract: The invention relates to a water-insoluble reaction product of an oil-soluble high carbon polar modified polymer and a polyamine.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: May 26, 2015
    Assignee: L'OREAL
    Inventors: Hy Si Bui, Mohamed Kanji, Chunhua Li, Anita Chon Tong, Susan Halpern, Bruno Bavouzet
  • Veterinary compositions for controlling ecto- and endoparasites in bovines, use of these compositions, use of IGR substances associated with microminerals, method for controlling ecto- and endoparasites in bovines and kit
    Patent number: 9040586
    Abstract: Veterinary compositions are described for controlling ecto- and endo-parasites in animals, such as bovine. The compositions contain an IGR compound(s) or a benzoyl substituted urea(s) along with a mineral mix and at least one carrier.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: May 26, 2015
    Assignee: Champion Farmoquimico Ltda.
    Inventor: Flávio Alves da Rocha
  • Combination for the treatment of osteoarthritis
    Patent number: 9040575
    Abstract: The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: May 26, 2015
    Assignee: PROFESSIONAL DIETETICS, S.R.L.
    Inventors: Franco Conti, Francesco Saverio Dioguardi
  • Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same
    Patent number: 9034850
    Abstract: Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: May 19, 2015
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Seon Mi Kim, Min Hee Lee, Jae Sun Kim, Hoe Chul Jung, So Young Lee, Soo Min Lee, Eun Jeong Kim, Eui Sun Park, Sung Hoon Park, Bong Yong Lee, Key An Um
  • Composition for maintaining function of platelets
    Patent number: 9034922
    Abstract: A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein X represents a phenylene group; Y represents any one of a hydrogen atom and —(CH2)mR1; wherein m represents an integer of any one of 0 to 4; and R1 is any one of —NR5COR2, —NR5SO2R2, and —NR3R4; wherein R2 represents any one of a C1 to C6 alkyl group, an aryl group, a C1 to C6 alkoxy group, and the like; R3 and R4 represent a C1 to C6 alkyl group or the like; and R5 represents any one of a hydrogen atom, a C1 to C6 alkyl group, and the like; and Z represents any one of a hydrogen atom and a C1 to C6 alkyl group.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 19, 2015
    Assignees: THE UNIVERSITY OF TOKYO, KAKEN PHARMACEUTICAL CO., LTD.
    Inventors: Koji Eto, Ryoko Ohnishi, Hiromitsu Nakauchi, Takahiko Murata
  • Bridged heterocyclic compounds and methods of use
    Patent number: 9034869
    Abstract: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic[4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: May 19, 2015
    Assignee: Medivation Technologies, Inc.
    Inventors: David T. Hung, Andrew Asher Protter, Sarvajit Chakravarty, Rajendra Parasmal Jain
  • Solid ganaxolone compositions and methods for the making and use thereof
    Patent number: 9029355
    Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: May 12, 2015
    Assignee: Marinus Pharmaceuticals
    Inventors: Kenneth Shaw, Mingbao Zhang
  • Intranasal carbetocin formulations and methods for the treatment of autism
    Patent number: 9023793
    Abstract: Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: May 5, 2015
    Assignee: Retrophin, Inc.
    Inventors: Alexis Kays Leonard, Joshua Orion Sestak, Henry R. Costantino, Anthony P. Sileno, Lalit Raj Peddakota, Kayvon Emile Sharghi, Garland M. Bellamy, Jason Philip Gesty, Steven C. Quay
  • Method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells
    Patent number: 9018251
    Abstract: Provided is a method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells in a subject, comprising administrating to the subject an effective amount of an active ingredient selected from the group consisting of (Z)-butylidenephthalide of formula (I), a pharmaceutically acceptable salt of (Z)-butylidenephthalide, a pharmaceutically acceptable ester of (Z)-butylidenephthalide, and combinations thereof:
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: April 28, 2015
    Assignee: China Medical University
    Inventors: Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou, Po-Cheng Lin
  • Monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)-piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, preparation, and pharmaceutical composition thereof
    Patent number: 9012459
    Abstract: The disclosure is directed to a monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, possessing diffraction peaks of about 12.9°, 15.9°, 17.9°, 21.2°, 22.9°, 23.5° and 24.5°. Its preparation method and pharmaceutical composition thereof are also provided.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 21, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Yen-Fang Wen, Yuan-Jang Tsai, Wan-Ru Chen, Tsan-Lin Hu, Chia-Mu Tu, Chih-Peng Liu
  • Lipophilic curcumin analogs and methods of inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia
    Patent number: 9012490
    Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: April 21, 2015
    Assignee: Howard University
    Inventors: Evaristus A. Nwulia, Amol Kulkarni
  • Couplers for medium-chain fatty acids and disinfecting compositions
    Patent number: 9006286
    Abstract: A disinfecting shower cleaner composition including a medium-chain fatty acid coupled with a nonionic surfactant providing temperature stable antimicrobial compositions. The invention specifically relates to antimicrobial compositions including fatty acid antimicrobial agents coupled with an ethoxylated amine and methods of using the antimicrobial compositions.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: April 14, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Elizabeth R. Kiesel, Michael E. Besse, Lisa A. Hellickson, Mark D. Levitt, Daniel E. Pedersen
  • Bridged heterocyclic compounds and methods of use
    Patent number: 8999977
    Abstract: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: April 7, 2015
    Assignee: Medivation Technologies, Inc.
    Inventors: David T. Hung, Andrew Asher Protter, Sarvajit Chakravarty, Rajendra Parasmal Jain
  • Fungicide hydroximoyl-heterocycles derivatives
    Patent number: 9000012
    Abstract: The present invention relates to hydroximoyl-heterocycle derivatives, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: April 7, 2015
    Assignee: Bayer Cropscience AG
    Inventors: Christian Beier, Jurgen Benting, David Bernier, Pierre-Yves Coqueron, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Pierre Genix, Daniela Portz, Ulrike Wachendorff-Neumann
  • Anthraquinone based near IR emitting compounds and uses thereof
    Patent number: 8999965
    Abstract: Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: April 7, 2015
    Assignee: Life Technologies Corporation
    Inventors: Stephen Yue, Shih-Jung Huang, Jolene Bradford