Abstract: In an ampoule for a medicament the space accommodating the medicament is defined by an ampoule wall (1) a pierceable seal (5) closing one end of the ampoule and a piston (7) closing the other end of the ampoule. A metal containing fixation element (8) is secured to one of the parts defining the medicament accommodating space. A mixing element (9, 10) also containing a metal and having a density larger than 1,0 g/cm.sup.3 is movable in medicament accommodating space. At least one of the elements, the fixation element (8) and the mixing element (9, 10), can be attracted by a magnet, and at least one of these elements is a magnetic element, the magnetic strength being so that the mixing element (9, 10) can during normal handling of the ampoule be fixed relative to this ampoule by the magnetic attraction between the fixation element (8) and the mixing element (9, 10) but may be released from its fixed position by manual operation.

Abstract: A safety vein syringe with retractable special needle, including a syringe barrel, a plunger, an injection needle and a guiding mechanism formed between the needle holder and the plunger. By means of the guiding mechanism, the plunger can be only axially moved within the barrel without rotation and two needle pulling members can be easily aligned with each other and latched together. The first needle pulling member is formed on the needle holder or the plunger, having at least one rotatable click. The second needle pulling member is formed on the plunger or the needle holder, having a detent. When the piston of the plunger is pushed to the bottom, the detent is easily and firmly engaged and hooked with the click. Thereafter, the injection needle and the needle holder can be together pulled into the barrel with the tip of the injection needle positioned under the shoulder section of the barrel.

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.

Abstract: The invention relates to a process for manufacturing an injection device of the pre-filled type comprising producing, in a deformable plastics material, a tubular syringe body (101) equipped with an external locking element (104) suitable for deforming radially between retracted and dilated positions, producing a tubular sheath (109) equipped with an internal locking element (110, 111) paired with that of the syringe body (101), fitting the sheath (109) round the syringe body (101), by a relative sliding of these latter permitted by the radial retraction of the locking element (104) of the syringe body (101), and introducing into the syringe body (101) a rigid pre-filled container suitable for bringing the locking element (104) of the said syringe body into its dilated position, enabling an irreversible locking of the sheath (109) to be obtained once it has been brought, after injection, into an advanced, post-use protection position.

Abstract: Dimensionally stable plunger rod for use with a plunger in a cartridge or syringe barrel for manual or power-assisted withdrawing of fluid from a site or expelling fluid from the cartridge or syringe barrel having:a plunger rod body with distal end proximal ends;an end disc at the distal end;a threaded member integral with the end disc designed to engage a plunger;a thumb rest at the proximal end;a reinforcing disc at about the longitudinal mid point of the plunger body;a first pair or rectangular radially extending vanes connecting the end and reinforcing discs;a second pair or rectangular radially extending vanes connecting the reinforcing disc and the thumb rest;a first pair of triangular radially extending vanes connecting the end disc and the reinforcing disc; anda second pair of triangular radially extending vanes connecting the reinforcing disc and the thumb rest.

Abstract: A transdermal system (1) for the administration of at least two substances through the skin with the aid of an electric current has a reservoir, which comprises a storage layer (2) for the substances, and a transfer means, which may be arranged in the form of a separating layer (3), that is connected to both the reservoir and the patient's skin (5) during administration. The transdermal system also has electrodes (4) which generate a current that transports the substances from the reservoir into the skin (5). In the transdermal system (1) means for the physical separation of the substances are provided that render possible a sequential administration of the substances.

Abstract: A steerable catheter (310) having a handle, a manifold strain relief (314) securely mounted at a front distal end of the handle, a steering dial (316) rotatably mounted within the handle, the steering dial (316) comprises a steering dial left fastener (316L) and a steering dial right fastener (316R). A lumen extrusion shaft (318) is securely fastened at a rear distal end to the manifold strain relief(314). The lumen extrusion shaft (318) has at least one lumen extrusion shaft large lumen opening (318B) and at least one lumen extrusion shaft small lumen opening (318C) contained therein. A lumen extrusion tip (320) is securely fastened at a front distal end of the lumen extrusion shaft (318) by a lumen extrusion shaft connection (318A). A manifold (334) is securely fastened at a rear end of the manifold strain relief (314). At least one luer lock (324) is securely mounted at a rear distal end of the handle. A steering wire (328) securely fastened at a rear distal end to the steering dial (316).

Abstract: A disposable irrigation device for a motorized surgical tool comprises a cannula with a cylindrical clip bonded near one end. The clip has a C-shaped cross-section with a slot. Both the cannula and the clip are formed from malleable material which may be manually formed into a resilient desired shape. The surgical tool has a rotatable tool implement extending from a cylindrical guide member. The device is attached to the tool by inserting the guide member into the clip so that one end of the cannula is located near the implement. The malleable clip clamps around and frictionally engages the guide member. The malleable cannula may be bent to precisely direct the flow of irrigation fluid relative to the implement. For implements of greater length, the device may be inverted and attached in the opposite direction.

Abstract: The invention features a catheter particularly for the delivery of a therapeutically active substance comprising a catheter body and an inflatable structure comprising three inflatable elements and a diaphragm fixed to these elements and defining with them, a passage duct for the body fluid and a sealed cavity to contain a therapeutically active substance. The said first (3), second (4) and third (7) inflatable elements are made of one preformed piece consisting of a helically coiled tube, said third element (7) being constituted by one or more turns of the coil, the diameter of the said tube at the portion constituting the third element being less than the diameter of the said tube at the tube portions constituting the said first and second elements respectively and intended to rest against the internal wall of said body duct; the said catheter body is disposed inside the coil of the said tube, in the aforementioned duct. This invention is useful in the preventive treatment of restenosis.

Abstract: A system for enhancing and improving the transcutaneous or transdermal delivery of topical chemicals or drugs. A disposable container contains a substantially sterile unit dose of an active agent adapted for a single use in a medical treatment. The unit dose is formulated to enhance transport of the active agent through mammalian skin when the active agent is applied to the skin and the skin is exposed to light and/or ultrasound defined by at least one specific parameter.

Abstract: In the performance of vascular anastomosis, in order to improve and simplify the making of the connection between the vessels, a surgical instrument is proposed which is characterized by a tubular shaft closed at the front end thereof, with an outer diameter which enables introduction into one of the vessels, with suction openings in the wall of the shaft in the area of the front end thereof, and with a suction connection on the shaft at a distance from the front end thereof.

Abstract: A gastrostomy apparatus includes an elongated tube having an inflatable balloon at its distal end, the tube passing through a flexible hemisphere. A spacer, which can be another tube or sheath, surrounds the primary tube in the region between the hemisphere and the proximal end of the tube. When the tube has been inserted into the patient, the balloon is inflated, and the tube pulled back so that the balloon abuts the interior wall of the stomach. The hemisphere is positioned to abut the skin or the exterior of the abdominal wall, and the spacer is affixed to the tube so that the hemisphere cannot migrate towards the proximal end of the tube. The spring action of the hemisphere counteracts the peristaltic motions of the stomach, and tends to keep the apparatus in place. The apparatus thus reduces the likelihood of leakage of gastric contents, and thus minimizes the risk of infection at the gastrostomy site.

Abstract: A steerable direct myocardial revascularization catheter comprises a catheter body, a tip section and a control handle. The catheter body has an outer wall, proximal and distal ends and at least one lumen extending therethrough. The tip section comprises flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The control handle comprises a first member fixedly attached to the proximal end of the catheter body, a second member being movable relative to the first member, and a first guide tube extending through the control handle from the proximal end to the distal end of the control handle. The first guide tube is fixedly attached to one of the first or second members. The catheter also comprises an optic fiber having a distal end and a proximal end.

Abstract: A self-administration device for liquid drugs, which can be filled in a short time without troubles such as leakage and is capable of a pushing operation in one-touch. The self-administration device for liquid drugs includes a casing 1; a port portion 2; a reservoir 3 having an open end which is closed by the port portion 2 and is capable of being restored to its original shape; and pushing means 4 for pushing the reservoir 3, wherein the reservoir 3 is pressed by the pushing means 4 to inject the liquid drug. The pushing means 4 includes a cylindrical member inserted slidably into the inner wall of the casing 1, and a spring member housed in the cylindrical member. The cylindrical member and the port position 2 are respectively provided with a male hook 425 and a female hook 25, for acting as detachable mutual engagement means.

Abstract: A syringe type apparatus which includes a unique fill assembly for use in controllably injecting medicinal fluids into a patient. The filling assembly includes a prefilled vial which is partially received within a novel adapter assembly that functions to operably couple the prefilled vial with the syringe assembly of the apparatus. The body of the prefilled vial is surrounded by a protective covering until immediately prior to mating the assembly with the syringe assembly.

Abstract: The invention relates to a catheter device and method of use for exchanging a catheter having a full-length guidewire lumen over a conventional-length guidewire without the use of a guidewire extension or an exchange wire. The catheter device includes an elongated shaft defining an inflation lumen and a guidewire lumen extending longitudinally throughout its length, and a hydraulic exchange lumen extending from the proximal end of the shaft and terminating proximal the distal end of the shaft, wherein the hydraulic exchange lumen is in fluid communication with the guidewire lumen. A balloon is coupled to the distal section of the shaft and is in fluid communication with the inflation lumen. A flow guiding member is disposed within the guiding catheter and functions to redirect the distal flow of pressurized fluid traveling through the hydraulic exchange lumen in a proximal direction through the guidewire lumen.

Abstract: A catheter introducer is disclosed having a splittable introducer and an introducer needle. The splittable introducer includes a pair of wings and a tray with an open top extending from the proximal end of the introducer cannula between the wings to lead the distal end of a long, thin and flexible medical device into the open proximal end of the splittable introducer cannula.

Abstract: A balloon dilatation catheter having a catheter shaft with an oblong transverse cross-section with one transverse dimension in a first direction being significantly larger than a second transverse dimension in a direction perpendicular to the first direction. The first dimension is about 1.1 to about 3 times greater, preferably about 1.2 to about 2.5 times greater than the second dimension. In one embodiment, a length of the distal shaft section has inner and outer tubular members where about 30% to not more than about 90% of the inner periphery of the outer tubular member takes the shape of and is secured to the exterior of the inner tubular member. In another embodiment the flexible distal shaft section is an extruded section having an oval or elliptical transverse cross-section. Preferably a pseudoelastic hypotube of NiTi alloy defines at least part of the inflation lumen within the catheter shaft.

Abstract: A method for simultaneously isolating the flow of blood in a nasal cavity and withdrawing the blood from the nasal cavity is disclosed. The method comprises the steps of inserting a catheter into the nasal cavity. The catheter is composed of a tube and a duct and a forward end capable of being enlarged to form a balloon. Once the catheter is positioned in the nasal passage, air is pumped into the catheter through the tube to inflate the balloon. The inflated balloon forms a seal within the nasal cavity that prevents the flow of blood beyond the seal.Simultaneously, blood is drawn into the catheter by applying a suction force to the duct. Suction may be accomplished by attaching a vacuum at the opposite end of the catheter and connecting it to the duct. The blood is drawn into the duct through a plurality of holes that connect the periphery of the catheter with the duct. The blood thus drawn into the duct is removed from the nasal cavity and disposed away from it.

Abstract: A tip cap is provided for positive sealing engagement with the tip of a syringe barrel. The tip cap includes an inner cap formed from an elastomeric material dimensioned for sealing engagement with the tip of the syringe barrel. The tip cap further includes an outer cap engaged with the inner cap to limit or prevent both axial movement and rotational movement therebetween. The outer cap includes an array of threads for threaded engagement with a luer collar. The luer collar may be a separate component mountable to a syringe barrel or an integral part of the syringe barrel.