Abstract: The present invention relates to mutant 1,3-propanediol dehydrogenase and a novel microorganism that is capable of growing in concentrations of at least 105 g/l 1,3-propanediol, levels normally toxic to wild-type microorganisms. The present invention also provides expression vectors and host cells comprising the mutant 1,3-propanediol dehydrogenase as well as methods for producing 1,3-propanediol comprising the use of cells comprising the mutant 1,3-propanediol dehydrogenase.
Type:
Grant
Filed:
May 14, 2000
Date of Patent:
October 22, 2002
Assignee:
Genencor International, Inc.
Inventors:
Trimbur E. Donald, Whited M. Gregory, Olga V. Selifonova
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
March 6, 2001
Date of Patent:
November 27, 2001
Assignee:
PE Corporation (NY)
Inventors:
Jane Ye, Karen A. Ketchum, Valentine Di Francesco, Ellen M. Beasley
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