Abstract: The present invention relates to devices, systems and methods for detecting disturbances that may occur during the sleep of a subject using measurements and assessments of mandibular rotation and movement of a sleeping subject. A sensing unit may be positioned onto the exterior of the subject's mandible and may generate data measurements corresponding to mandibular rotation and movement. For example, measurements by an accelerometer and gyroscope corresponding to rotation and movement of the mandible provide the necessary information to arrive at an accurate assessment of sleep stages, sleep indicators and/or other sleep related information which may be used to make recommendations regarding sleep conditions and/or disorders. A report may be generated including such sleep stages, sleep indicators and/or other sleep related information as well as any recommendations regarding sleep conditions and/or disorders for use for diagnosing sleep events such as obstructive sleep apnea (OSA).

Abstract: A steerable guidewire. The steerable guidewire is fabricated includes an outer tube, an inner tube, a hub, and a distal articulating region. The steerable guidewire hub can be removed to permit advancement of catheters over its proximal end followed by re-attachment of the hub to permit deflection of the distal end of the steerable guidewire.

Abstract: An instrument for collecting tissue from a body cavity includes a hollow tubular body having a tubular wall. The hollow tubular body can collect material from a body cavity in a coring mode or an aspiration mode. The tubular wall defines a passage that extends from a proximal end portion of the tubular body to a distal end portion of the tubular body. A middle section of the tubular body includes an articulating section that allows the middle section to articulate relative to the proximal end portion. The distal end portion includes at least one suction port extending from an outer wall surface to an inner wall surface of the tubular wall. The suction port provides a path of fluid communication between the outer wall surface and the passage for drawing in tissue from a body cavity when the tubular body is connected to a source of negative pressure.

Abstract: A syringe-based device for procuring bodily fluid samples can include a housing having a port that can be coupled to a lumen-defining device for receiving bodily fluids, an actuator mechanism including a pre-sample reservoir, a removable plunger cap operably coupled with pre-sample reservoir, a plunger tube, a valve, a plunger seal, and a selectively attachable collection vial for capturing a bodily fluid sample.

Abstract: The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

Abstract: A mouth guard, or wearable device, senses impact forces, calculates risk factors for injury, and displays status of risk and potential injury. A mouth guard may be used to identify, treat and prevent exacerbating brain injury. A wearable device can be programmed with biometric data to better calculate and anticipate impact thresholds and more precisely predict and prevent injury.

Abstract: An allergy testing device is disclosed. The allergy testing device includes a first applicator, a second applicator, a capture device, and a processor. The first applicator is arranged to apply an allergen to a first predetermined area of a patient's skin. The second applicator is arranged to apply antigen epitopes within a second predetermined area of a patient's skin. The capture device has a projector and one or more cameras. The processor is in communication with the capture device and a drive device that is arranged to move the first applicator to apply the allergen to the patient's skin and to move the second applicator to apply antigen epitopes to the patient's skin.

Abstract: Generator systems and methods are provided for generating a neuromuscular-to-motion decoder from a healthy limb. The generator system is configured to receive neuromuscular signals from neuromuscular sensors associated to predefined muscle/nerve locations of at least one pair of agonist and antagonist muscles/nerves of the healthy limb, obtained during performance by the person of a predefined exercise (defined by predefined exercise data) with the healthy limb; to receive motion signals from motion sensors associated to predefined positions of the healthy limb, during performance by the person of the predefined exercise with the healthy limb; and to generate the neuromuscular-to-motion decoder by mapping the neuromuscular signals to the motion signals over time using a mapping method. Rehabilitation systems are also provided for rehabilitating a paretic limb by using a neuromuscular-to-motion decoder produced by a generator system.

Abstract: A modulated physiological sensor is a noninvasive device responsive to a physiological reaction of a living being to an internal or external perturbation that propagates to a skin surface area. The modulated physiological sensor has a detector configured to generate a signal responsive to the physiological reaction. A modulator varies the coupling of the detector to the skin so as to at least intermittently maximize the detector signal. A monitor controls the modulator and receives an effectively amplified detector signal, which is processed to calculate a physiological parameter indicative of the physiological reaction.

Abstract: The present invention relates to devices, systems and methods for detecting disturbances that may occur during the sleep of a subject.

Abstract: A femoral region supporter (2) supports a femoral region of a user (1) in a travel direction. A force detector (3) detects force received by the femoral region supporter (2) from the femoral region of the user (1). A walking motion estimator (4) estimates walking motion of the user (1) based on the force detected by the force detector (3). The video generator (5) generates a video to be presented to the user (1) based on the walking motion estimated by the walking motion estimator (4). The video presenter (6) presents the video generated by the video generator (5) to the user (1).

Abstract: A biological fluid collection device that is adapted to receive a blood sample is disclosed. The biological fluid collection device includes a housing, a puncturing element transitionable between a pre-actuated position wherein the puncturing element is retained within the housing and a puncturing position wherein at least a portion of the puncturing element extends through the housing, and a cartridge removably connectable to a portion of the housing. After collecting a blood sample, the cartridge is removable from the housing and the cartridge is able to transfer the blood sample to a point-of-care testing device. The biological fluid collection device provides a closed system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer.

Abstract: The disclosure provides a dynamic interaction-oriented subject's limb time-varying stiffness identification method and device. The method includes: the combination of subject's limb displacement and measured force data or the combination of angle and measured torque data is collected; based on the time-varying dynamic system constructed based on a second-order impedance model, the linear parameter varying method is utilized to substitute the time-varying impedance parameters and reconstruct the restoring force/torque expression; iterative identification is performed on variable weights, dynamic interaction force/torque, and restoring force/torque by using time-varying dynamic parameters based on the dynamic interaction force/torque expression expanded from basis function; the time-varying stiffness is solved by using variable weights and dynamic interaction force/torque according to expression with substituted the time-varying impedance parameters.

Abstract: A gait evaluation apparatus that evaluates a training gait of a paralyzed patient suffering from paralysis in a leg includes an acquisition unit configured to acquire a plurality of motion amounts of a paralyzed body portion according to a gait motion and an evaluation unit configured to evaluate that the gait motion is an abnormal gait in a case where at least one of the motion amounts acquired by the acquisition unit meets any one of a plurality of abnormal gait criteria set in advance. The abnormal gait criteria include at least two or more first criteria, which are criteria relevant to motion amounts of different parts of the paralyzed body portion, or at least two or more second criteria, which are criteria relevant to motion amounts of the same part of the paralyzed body portion in different directions.

Abstract: There is provided herein a motion-based evaluation of reaction time that utilizes motion detection hardware of a mobile device to determine auditory and visual stimulated reaction time. In an embodiment, the subject holds a mobile computing device equipped with built-in triaxis accelerometer and gyroscope with both hands at arms length away from the face. A visual or auditory stimulus is then presented on screen via a software application that also records the response time for the individual to initiate a movement of the device. A simple reaction time test could include the movement of the device in any direction that exceeded a threshold of movement beyond what would be expected from static holding. An embodiment of a choice reaction time test would provide for specific directional movements as it related to an instructed stimulus.

Abstract: A measurement chamber that is essentially dome shaped and has a base area with a membrane and has at least two connection points fora fluid flow. The measurement chamber has two outer webs opposite each other, one of the webs engaging a clamping edge of a coupling element.

Abstract: Provided is an apparatus for measuring implant osseointegration, and the apparatus for measuring implant osseointegration includes: a vibration generation unit configured to apply multiple vibrations with frequencies in different bands, respectively, to an implant fixture; a vibration sensor configured to measure three-axis vibration information of the implant fixture caused by the vibrations from the vibration generation unit; and a control unit configured to determine the degree of osseointegration based on the measured vibration information.

Abstract: Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.

Abstract: Disclosed is an apparatus for diagnosing vertigo and balance related ailment using Craniocorpography (CCG) technique. The apparatus includes a helmet adapted to be worn over a head of a patient. The helmet includes a plurality of light emitting diodes (LEDs). Further, the apparatus includes a camera placed directionally above at a vertical distance from the helmet while the helmet is being worn over the head of the patient. The camera is adapted to track movement of the patient when the CCG is performed on the patient. Furthermore, the apparatus includes an interface card adapted to connect the camera. The interface card is adapted to relay images captured by the camera. A computing system in communication with the interface card is also provided. The computing system is adapted to analyze and present at least a plurality of patient alignment parameters based on the images captured by the camera.

Abstract: A wearable device for monitoring medical properties of a patient, the device having a rigid frame, multiple members coupled to the rigid frame, and a housing having an electrical circuit, where the housing is secured to the rigid frame, where the rigid frame surrounds a void, and where the void is configured to accommodate a bottom surface of the housing.