Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
Type:
Grant
Filed:
October 12, 2020
Date of Patent:
September 13, 2022
Assignee:
XWPHARMA LTD.
Inventors:
Jia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-Si Eng
Abstract: The present invention is directed to novel silane disulfide vegetable oils, a method of making the oils, their use in rubber compositions, and their use in tires.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
September 13, 2022
Assignee:
The Goodyear Tire & Rubber Company
Inventors:
Joseph John Kulig, Kelsey Elizabeth Cantwell, Frank James Feher, Thomas Franklin Spilker, George Jim Papakonstantopoulos
Abstract: A fragrance composition comprising a compound represented by Formula (1): wherein, in Formula (1), R represents a linear, branched, or cyclic alkyl group having 2 to 6 carbon atoms.
Abstract: The present disclosure provides method for isolating a long chain dicarboxylic acid such as a substantially pure or pure long chain dicarboxylic acid from a fermentation broth containing microbial cells.
Abstract: Provided is a method for purifying organic acids, including: a first extraction which includes separating an aqueous solution of organic acids into a first organic layer and a first aqueous solution layer by adding a solvent containing an amine and an alcohol; removing the alcohol from the separated first organic layer; and a second extraction which includes separating the first organic layer from which the alcohol has been removed into a second organic layer and a second aqueous solution layer by adding water.
Abstract: Process for refining vegetable oil, to suppress the formation of monochloropropanediol esters (MCPDe) and reduce the content of glycidyl esters, comprising first and second refinement stages, wherein the first refinement stage comprises: a) providing a crude vegetable oil having a combined MCPDe and glycidyl ester content below 0.2 ppm; b) degumming the crude vegetable oil to produced degummed vegetable oil; c) bleaching of the degummed vegetable oil with activated bleaching earth under reduced pressure to yield bleached vegetable oil; d) adding a base to the bleached vegetable oil and subsequent stripping and deodorizing under reduced pressure at a temperature below 255° C. to yield an intermediate refined vegetable oil; and a second refinement stage comprising the steps of: e) bleaching of the intermediate refined vegetable oil using activated bleaching earth under reduced pressure to yield a bleached vegetable oil; and f) deodorizing at a temperature below 220° C.
Type:
Grant
Filed:
August 22, 2018
Date of Patent:
August 23, 2022
Assignee:
Bunge Loders Croklaan B.V.
Inventors:
Krishnadath Bhaggan, Erik Johan Anton Schweitzer, Jeanine Luvelle Werleman
Abstract: The present invention provide for preparing a formylalkenyl alkoxymethyl ether compound of the following general formula (2): R3CH2OCH2O(CH2)aCH?CHCHO (2), wherein R3 represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group; and “a” represents an integer of 1 to 10, the process comprising: hydrolyzing a dialkoxyalkenyl alkoxymethyl ether compound of the following general formula (1): R3CH2OCH2O(CH2)aCH?CHCH(OR1)(OR2) (1), wherein R1 and R2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, or R1 and R2 may form together a divalent hydrocarbon group, R1-R2, having 2 to 10 carbon atoms; and R3 and “a” are as defined above, in the presence of an acid while removing an alcohol compound thus generated to form the formylalkenyl alkoxymethyl ether compound (2).
Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.
Abstract: A process for extraction of crude oil from distillers dried grain solubles and/or distillers dried grains using a solvent extraction process and producing corn distillers meal that may be used as an animal feed supplement is disclosed. The corn distillers meal may be used as a crude protein supplement for use in a livestock feed diet, poultry feed diet, aquatic feed diet or the like. The solvent extracted crude oil may be suitable for other processes, including oleochemical processing for personal care and home care products, biodiesel production, and/or renewable diesel production from hydro-treating the extracted oil to make green diesel fuel.
Type:
Grant
Filed:
March 31, 2021
Date of Patent:
August 16, 2022
Assignee:
Novita Nurtition, LLC
Inventors:
Keith Bruinsma, Donald Endres, Steven J. Furcich
Abstract: The current invention relates to a method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica and to an oil and to a delipidated biomass as obtained by such a method.
Type:
Grant
Filed:
May 7, 2019
Date of Patent:
August 16, 2022
Assignees:
Evonik Operations GmbH, DSM IP Assets B.V.
Abstract: Provided is a method for manufacturing a terephthalate-based composition, the method comprising: a step (S1) of flowing in a dialkyl terephthalate in which alkyl has 7 to 10 carbon atoms and a primary alcohol with a low boiling point having 4 or 5 carbon atoms into a reactor and performing transesterification of the dialkyl terephthalate and the primary alcohol with a low boiling point; and a step (S2) of extracting in a reduced pressure an unreacted material and a by-product from the reactor after finishing the transesterification, wherein the step S1 comprises a pressure-applying step in which the pressure of the reactor is 1.5 to 2.5 bar.
Type:
Grant
Filed:
September 18, 2019
Date of Patent:
August 9, 2022
Assignee:
LG Chem, Ltd.
Inventors:
Seok Goo Lee, Sung Kyu Lee, Joon Ho Shin
Abstract: The present disclosure relates to the formation of dimethyl terephthalate (DMT). The present invention also relates to the depolymerization of polyethylene terephthalate (PET) and the recovery of dimethyl terephthalate (DMT).
Abstract: A compound, represented by Formula (1): where X represents an isopropyl group or a t-butyl group, and R represents a linear, branched, or cyclic alkyl group having 1 to 5 carbon atoms; provided that one where X is an isopropyl group, and R is a t-butyl group is excluded.
Abstract: The present invention provides a method for introducing substituents into the ?-position and the ?-position of an ?,?-unsaturated ketone, which not only can be used for the synthesis of a prostaglandin by a three-component coupling process, but also enables synthesis of a prostaglandin in a high yield by one-pot operation without requiring the use of a large excess amount of any of the three components required for the synthesis or using a highly toxic heavy metal as a catalyst or a solvent that is highly toxic to living bodies, and a method for synthesizing a prostaglandin using the same technical means.
Type:
Grant
Filed:
May 29, 2018
Date of Patent:
July 12, 2022
Assignee:
NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY
Abstract: A catalyst for catalytic oxidation of furfural to prepare maleic acid is composed of a carbon nitride doped with a potassium salt. A method for preparing the catalyst includes mixing the potassium salt, a precursor of the carbon nitride and a solvent to obtain a mixture, and drying and calcining the mixture to obtain the catalyst. A use of the catalyst in catalytic oxidation of furfural to prepare maleic acid, wherein the maleic acid is prepared by the step of oxidizing furfural in a solvent in the presence of the catalyst. The invention has the advantages that by using the method provided by the invention to prepare maleic acid, the conversion rate of furfural can be 99% or more and the yield of maleic acid can be up to 70.40%.
Abstract: A process for production fatty acids comprising: adjusting pH of a saponifiable material to a value above pH 7 by adding alkaline material; saponifying all saponifiable material by passing alternate electrical current through the material, wherein the said step of saponification occurs in a saponification reactor; acidulating the saponified material by adding acid to pH value below 4; isolating obtained free fatty acids from aqueous layer.
Type:
Grant
Filed:
September 8, 2018
Date of Patent:
July 5, 2022
Assignee:
SLGK ZAKLAD BADAWCZO-WDROZENIOWY PROCESÓW CHEMICZNYCH SPÓLKA Z ORGANICZONA ODPOWIEDZIALNOSCIA
Inventors:
Felix Samuel Sirovski, Henryk Lisaj, Jerzy Stanislaw Grzesiak, Mieczyslaw Karwowski
Abstract: A branched estolide compound of the formula: wherein x and y are equal to 1 or greater; wherein x+y=14; wherein n is 0, 1, or greater than 1; wherein R is H or wherein R=C1 to C18 straight alcohols or C4 to C12 branched alcohols; wherein R1 is a residual fragment of octanoic, decanoic, lauric, coconut, myristic, palmitic, stearic, oleic, iso-stearic or iso-oleic acids.
Type:
Grant
Filed:
January 25, 2021
Date of Patent:
June 28, 2022
Assignee:
The United States of America, as represented by the Secretary of Agriculture
Inventors:
Girma Biresaw, Steven C. Cermak, Helen N. Lew
Abstract: The use of hypophosphorous acid as a corrosion inhibitor for esterification reactions of free fatty acids contained in a fatty substance is described, particularly in the presence of an organosulfonic acid. The invention also relates to a method for the esterification of fatty acids.