Patents Examined by Yelena Gakh
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Patent number: 6617169Abstract: The invention features methods of selecting chemical peaks from two-dimensional magnetic resonance spectra for one-dimensional extraction and quantification methods using these one-dimensional extractions. The methods permit enhanced differentiation of particular peaks in two-dimensional magnetic resonance spectroscopy and allow for quantification of chemical concentrations in test samples, such as human brain tissue, having complex magnetic resonance spectra due to the presence of numerous chemicals. These new techniques can be used to provide information about the concentrations of a variety of chemicals, including metabolites, in both biological and non-biological media.Type: GrantFiled: March 30, 2001Date of Patent: September 9, 2003Assignee: McLean Hospital CorporationInventors: Yong Ke, Perry F. Renshaw, Bruce Cohen
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Patent number: 6617168Abstract: The present invention provides an evaluation method and an evaluation system of free halogen concentration which eliminate the necessity of early exchanging or recycling of catalysts, as compared with a conventional method or system. In the present evaluation method of free halogen concentration, a main flow path of a sample liquid for evaluation and a sub-region that communicates with the main flow path are formed, a potential-measuring electrode is installed in the main path, while a reference electrode is installed in the sub-region at a position where free halogen in the sample liquid has been decomposed. Moreover, free halogen in the sample liquid is decomposed by a free-halogen decomposing substance in the sub-region, and the free halogen concentration is evaluated from the electric potential difference between the reference electrode and the potential-measuring electrode.Type: GrantFiled: January 6, 1999Date of Patent: September 9, 2003Assignee: Omega Co., Ltd.Inventors: Shinichi Nakamura, Kunihiko Fukutsuka, Yasushi Hanano
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Patent number: 6613574Abstract: A method of identifying interface residues in a biomolecular complex are identified by selecting one molecule with residues to be identified, and the nonexchangeable hydrogens (protons) and not less than 70% of exchangeable hydrogens (protons) in the one molecule are exchanged to deuteriums, followed by positional identification of the exchangeable hydrogens (protons) which are located on this molecule within 10 angstrom (Å) from hydrogen (s) (proton(s)) in a neighboring biomolecule in the complex and are cross-saturated by cross-saturation phenomena through the interface in the complex. Using the inventive method, the contact interfaces of biomolecular complex such as protein—protein complexes can be identified more accurately and easily than traditional methods.Type: GrantFiled: February 28, 2001Date of Patent: September 2, 2003Assignee: Ajinomoto Co., Inc.Inventor: Ichio Shimada
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Patent number: 6613577Abstract: The antioxidant power of an organic or inorganic liquid is determined by causing it to enter into competition with bathocuproine (BC) in a copper sulphate solution. Bathocuproine (BC) forms stable complexes with the monovalent Cu. Such a reaction is specific for Cu(I) and not for divalent Cu(II). Cu(II) in solution can be reduced to Cu(I) by a number of reducing compositions belonging to a class of compositions consisting prevailingly of both liposoluble and water soluble non-enzymatic antioxidants. When the reaction occurs in a bathocuproine (BC) buffer, the complex being formed is characterized by the concentration of the reducing agents and then, by good approximation, of the antioxidants present in the system. The quantitative analysis of such a reaction can be easily made by spectrophotometry at 480 nm both by macro- and micromethods with the use of a number of reducing standard compositions with known concentrations.Type: GrantFiled: May 9, 2001Date of Patent: September 2, 2003Assignee: Med. Dia SRL.Inventor: Giuseppe Da Cruz
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Patent number: 6610252Abstract: The present invention provides a system for lyophilization comprising one or more delivery containers, e.g. syringes, and a cover plate, which covers them during lyophilization. The cover plate includes a lid region and one or more protuberances, which project perpendicularly from the lid region and fit delivery containers such that the protuberances are not in complete and continuous contact with sidewalls of the delivery containers. The cover plate permits the escape of vapor from the delivery containers during lyophilization process through an annular gap between each protuberance and a sidewall of each container when the cover plate is resting on the top of the delivery containers. At the same the cover plate prevents the escape of lyophilizate, in particular a pharmaceutical, from the containers during lyophilization.Type: GrantFiled: January 22, 2002Date of Patent: August 26, 2003Assignee: Atrix Laboratories, Inc.Inventors: Dominic G. Madril, Cody L Yarborough, Rajan Bawa, Christopher J. Barrett
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Patent number: 6605258Abstract: A liquid chemical stripping or cleaning solution is selected by combinatorial high throughput screening. A high throughput screening well array assembly includes (A) a metal substrate and (B) a mask that defines an array of wells on the substrate. A combinatorial high throughput screening system includes (A) a metal substrate and (B) a mask that defines an array of wells on the substrate and a reaction vessel to receive the well array assembly.Type: GrantFiled: April 22, 2002Date of Patent: August 12, 2003Assignee: General Electric CompanyInventors: John Robert LaGraff, Xiao-Dong Sun, James Anthony Ruud, James Claude Carnahan
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Patent number: 6599753Abstract: This invention is directed to the use of 19F NMR spectroscopy to monitor and quantitate solid-phase reactions and fluorine-containing solid-phase reagents useful therefor.Type: GrantFiled: June 23, 1999Date of Patent: July 29, 2003Assignee: Aventis Pharmaceuticals Inc.Inventors: Vasant K. Nagulapalli, Edward Orton, John E. Airey, Paul H. Krolikowski, Joseph M. Salvino
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Patent number: 6599754Abstract: A reaction vessel and method of identifying a ligand having affinity for a target molecule are disclosed. The reaction vessel includes a first member defining a first chamber, the first chamber including an organic solvent and a plurality of reactants which form a combinatorial library of products; a second member defining a second chamber, the second chamber including a target molecule and an aqueous solvent immiscible in the organic solvent; and a semipermeable membrane separating the contents of the first chamber from the contents of the second chamber, wherein said semipermeable membrane is permeable to one or more products of the combinatorial library of products.Type: GrantFiled: April 20, 2001Date of Patent: July 29, 2003Assignee: University of RochesterInventors: Benjamin L. Miller, Bryan Klekota
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Patent number: 6589438Abstract: A device for detection of one or more analytes in a sample is disclosed. The device can simultaneously detect and quantitate multiple analytes in a sample. The device comprises an eletromagnetic radiation generator having one or more chemical sensors thereon. The chemical sensor interacts with or reacts with specific analytes in a sample. The presence of an analyte is detected by a comparison of the spectroscopic properties of the chemical sensor in the absence and presence of the analyte. A method is also disclosed for the detection and quantitation of analytes using the device of the present invention. In addition, a method of making the device of the present invention is also disclosed.Type: GrantFiled: September 25, 2002Date of Patent: July 8, 2003Assignee: The Research Foundation of State University of New YorkInventors: Frank V. Bright, Brett R. Wenner, Meagan A. Doody, Gary A. Baker
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Patent number: 6589795Abstract: The present invention relates to a method and a device for detecting mercury in a sample solution, the mercury being contained in the sample solution in cationic form and as an organic compound, by means of a detection device comprising an atomic spectroscope provided with a measuring cell which is suitable for detecting mercury gas, a noble-metal concentrator for concentrating the mercury and a control unit, the mercury being converted into the gas phase and being adapted to be concentrated by means of the noble-metal concentrator. The method according to the present invention is characterized in that the control unit controls the supply of the mercury gas to the measuring cell in such a way that, in addition to the measurement of the concentrated mercury, mercury gas of the same sample, which has not been subjected to the concentration step, is introduced in the measuring cell for the purpose of measurement.Type: GrantFiled: March 8, 2001Date of Patent: July 8, 2003Assignee: PerkinElmer Bodenseewerk Zweigniederlassung der Berthold GmbH & Co. KGInventors: Julian F. Tyson, Gerhard Schlemmer, Christopher Palmer
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Patent number: 6589788Abstract: The present invention is directed to a method for the rapid screening of potential reactants, catalysts, and associated process conditions. In an embodiment, the invention comprises a method for evaluating catalyst efficacy in polymerization reactions by the determination of product molecular weight and Fries products.Type: GrantFiled: October 19, 2000Date of Patent: July 8, 2003Assignee: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Ralph Joseph May, Ronald Eugene Shaffer, John Patrick Lemmon, Ronald James Wroczynski
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Patent number: 6586257Abstract: A multiwell plate scanner comprises a detector for measuring an attribute of a sample which is scanned continuously over wells of a multiwell plate. A signal obtained during the scan may be sampled and digitized based on detector position over the multiwell plate. The scanner is also disclosed for scanning microarrays, bio-chips and areas of samples not having physical separations. The scanner may be used in a high throughput screening system comprising a storage and retrieval module, a sample distribution module, a reagent distribution module, and a detector which incorporates the scanner. The screening system may further comprise a transport module and a data processing and integration module for transporting samples between the components of the system and for controlling system operation.Type: GrantFiled: September 19, 2000Date of Patent: July 1, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventor: T. Minh Vuong
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Patent number: 6582966Abstract: A device for detection of one or more analytes in a sample is disclosed. The device can simultaneously detect and quantitate multiple analytes in a sample. The device comprises an eletromagnetic radiation generator having one or more chemical sensors thereon. The chemical sensor interacts with or reacts with specific analytes in a sample. The presence of an analyte is detected by a comparison of the spectroscopic properties of the chemical sensor in the absence and presence of the analyte. A method is also disclosed for the detection and quantitation of analytes using the device of the present invention. In addition, a method of making the device of the present invention is also disclosed.Type: GrantFiled: September 25, 2002Date of Patent: June 24, 2003Assignee: The Research Foundation of State University of New YorkInventors: Frank V. Bright, Brett R. Wenner, Meagan A. Doody, Gary A. Baker
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Patent number: 6576471Abstract: A method for analyzing a patient's risk of coronary heart disease by determining the presence of NMR-derived or based lipoprotein constituent value abnormalities includes determining the presence of atherogenic dyslipidemia based on the existence of a clustering of lipoprotein constituent abnormalities as defined by predetermined test criteria. Computer program products and automatically produced reports for presenting NMR-derived lipoprotein risk assessment based on patient-specific lipoprotein subclass results present the measurement results adjacent to a segmented reference risk analysis portion. The actual measured results are visually aligned and enhanced within the risk analysis portion to provide easy reference and understanding of the results relative to a risk of developing coronary heart disease.Type: GrantFiled: November 14, 2001Date of Patent: June 10, 2003Assignee: LipoScience, Inc.Inventor: James D. Otvos
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Patent number: 6576197Abstract: The invention relates to a process for detecting the catalytic activity of solid materials, in which process one or more starting materials are brought to reaction in the presence of the solid materials, characterized in that the solid materials are present, spatially separated from one another, on a support, in that the starting materials are brought into contact with the solid materials and in that the resultant product or products are analyzed by a mass spectrometer, with resolution of location regarding the solid materials on the support. The advantages of the process according to the invention are essentially that a rapid serial or parallel detection of the catalytic activity of solid materials under identical conditions is now possible.Type: GrantFiled: April 8, 1999Date of Patent: June 10, 2003Assignee: Degussa AGInventors: Norbert Windhab, Christian Miculka, Hans-Ulrich Hoppe
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Patent number: 6573105Abstract: A test method for a coating liquid for an electrophotographic photoconductor includes calculating a peak area ratio of a component to be analyzed in a coating liquid by pyrolysis gas chromatography, and comparing the peak area ratio with a pre-obtained peak area ratio of the component in a reference coating liquid having a known content of the component, to determine the ratio and/or content of the component in the coating liquid. A control method for controlling a coating liquid based on the test result as obtained is also provided.Type: GrantFiled: June 6, 2000Date of Patent: June 3, 2003Assignee: Sharp Kabushiki KaishaInventors: Tomoko Kanazawa, Yoshihide Shimoda, Sayaka Fujita, Tadashi Nakamura, Masayuki Sakamoto, Tatsuhiro Morita
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Patent number: 6572826Abstract: Chemically sensitive sensors, suitable for detecting analytes in fluids (in gaseous or liquid phase), wherein the chemically sensitive sensors comprise a chemically sensitive probe, which comprises one or a blend of several arylene alkenylene oligomers.Type: GrantFiled: November 23, 1999Date of Patent: June 3, 2003Assignee: OligoSense NVInventors: Michaƫl De Wit, Emmanuel Vanneste, Frank Blockhuys, Gunter Verreyt, Wim Tachelet, Luc J. Nagels, Herman J. Geise
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Patent number: 6569686Abstract: This invention relates to a method for the determination of solubility of a compound and an analytical device for carrying out said method. The basic method involves determining solubility of a compound by measuring the UV spectrum of a reference solution of the compound, under conditions avoiding or suppressing precipitation, and comparing it to the UV spectrum of a saturated sample solution of the compound. Variations of the basic method include: (a) making reference solutions either by dilution of the sample solution to the point where precipitation is avoided, or making reference solutions by adding a water-miscible cosolvent to the sample solution so that precipitation is suppressed, and comparing the UV absorbances of the compound under reference conditions to the compound in a saturated solution, (b) determining the true aqueous solubility from the effect on the pKa that results from dissolving the compound in an aqueous solution containing some DMSO (typically 0.Type: GrantFiled: January 25, 2001Date of Patent: May 27, 2003Assignee: Pion, Inc.Inventors: Alex Avdeef, Konstantin L. Tsinman
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Patent number: 6566144Abstract: The present invention provides a cover plate that covers one or more delivery containers (e.g., syringe) during lyophilization. The cover plate includes a lid region and one or more protuberances which project perpendicularly from the lid region. The one or more protuberances are adapted to fit in the one or more delivery containers. The cover plate permits the escape of vapor from the one or more delivery containers during the lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during the lyophilization process. The present invention also provides a system for lyophilizing a solution that contains a pharmaceutical. The system includes one or more delivery containers. The one or more delivery containers contains the solution that contains the pharmaceutical. The system also includes a cover plate used to cover the one or more delivery containers during the lyophilization.Type: GrantFiled: March 27, 2000Date of Patent: May 20, 2003Assignee: Atrix LaboratoriesInventors: Dominic G. Madril, Cody L Yarborough, Rajan Bawa, Christopher J. Barrett
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Patent number: 6562627Abstract: Methods are provided for determining a dissociation constant for each one of at least a portion of a set of compounds. The methods include contacting a solution of the set of compounds with a membrane mimetic surface exhibiting a non-specific compound-dependent affinity for at least the portion of the compounds. A parameter dependent on the non-specific affinity of the surface for each one of at least the portion of the set of compounds in the test solution is measured and used to calculate the dissociation constant.Type: GrantFiled: December 23, 1999Date of Patent: May 13, 2003Assignee: BDC Pharma LLCInventors: Charles Pidgeon, Jianming Yin, Nadege Rooke, Ling Han Morgan