Patents Examined by Yong Chu
  • ?-hydroxy-?-aminophosphonates and methods for the preparation and use thereof
    Patent number: 8536362
    Abstract: The present invention provides ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: September 17, 2013
    Assignee: Nucitec S.A. de C.V.
    Inventors: Ricardo Abraham De La Cruz Cordero, Miguel Ångel Duarte Vázquez, Jorge Luis Rosado Loria
  • Indole modulators of S1P receptors
    Patent number: 8530462
    Abstract: The present invention relates to novel indole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: September 10, 2013
    Assignee: Allergan, Inc.
    Inventors: Santosh C. Sinha, Smita S. Bhat, Ken Chow, Michael E. Garst, Wha Bin Im
  • Ester compound and use thereof
    Patent number: 8530669
    Abstract: An ester compound represented by formula (1): wherein R1 represents C1-C4 alkyl, has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: September 10, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Noritada Matsuo
  • Deuterated compounds for luminescent applications
    Patent number: 8531100
    Abstract: This invention relates to deuterated compounds that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 10, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Norman Herron, Vsevolod Rostovtsev, Jeffrey A. Merlo, Michael Henry Howard, Jr., Adam Fennimore, Weiying Gao, Kalindi Dogra, Nora Sabina Radu, Weishi Wu, Eric Maurice Smith, Daniel David Lecloux
  • Substituted pyrimidinyl-amines as protein kinase inhibitors
    Patent number: 8530480
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: September 10, 2013
    Assignee: The Scripps Research Institute
    Inventors: Theodore Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael Darin Cameron, Derek R. Duckett
  • Heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
    Patent number: 8524718
    Abstract: The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 3, 2013
    Assignee: Addex Pharma S.A.
    Inventors: Christelle Boléa, Sylvain Celanire
  • 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases
    Patent number: 8524751
    Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: September 3, 2013
    Assignee: GlaxoSmithKline Intellecutual Property Development
    Inventors: Julie Nicole Hamblin, Zoe Alicia Harrison, Paul Spencer Jones, Suzanne Elaine Keeling, Joelle Le, Christopher James Lunniss, Nigel James Parr
  • (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds
    Patent number: 8524750
    Abstract: A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: September 3, 2013
    Assignee: Glaxo Group Limited
    Inventors: Lluis Ballell Pages, Julia Castro Pichel, Raquel Fernandez Menendez, Esther Pilar Fernandez Velando, Silvia Gonzalez Del Valle, Maria Luisa Leon Diaz, Alfonso Mendoza Losana, Matthew James Wolfendale
  • Cyclosporin derivatives for treating inflammatory diseases and conditions
    Patent number: 8524671
    Abstract: The present invention provides a method for the treatment of inflammatory diseases and/or conditions, e.g. allergic conjunctivitis, uveitis or phacoanaphylactic endophthalmitis in an eye of a mammal, said method comprising administering to said mammal in need of treatment a therapeutically effective amount of a novel cyclosporin A derivative selected from the group consisting of compounds represented by the formula: wherein R1 is S-Alk-R wherein Alk is an alkylene linkage, preferably a methylene or poly methylene linkage, or a polyalkenylene linkage, e.g. a C3 to C6 alkenylenyl linkage and R is a hydrogen or a unsubstituted or substituted hydrocarbyl group.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: September 3, 2013
    Assignee: Allergan, Inc
    Inventors: Michael E. Garst, Michael E. Stern
  • Heteroalkyl biphenyl antagonists of prostaglandin Dreceptors
    Patent number: 8524748
    Abstract: Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: September 3, 2013
    Assignee: Panmira Pharmaceuticals, LLC
    Inventors: John Howard Hutchinson, Thomas Jon Seiders, Jeannie M. Arruda, Jeffrey Roger Roppe
  • Hydrocarbon synthesis and production onboard a marine system using varied feedstock
    Patent number: 8513316
    Abstract: A process for producing Fischer-Tropsch hydrocarbon products onboard a marine vessel from carbonaceous feedstock by gasification in a thermal conversion plant connected to an onboard power plant unit includes the steps of forming Fischer-Tropsch hydrocarbons in a Fischer-Tropsch reactor having a recycle line from the Fischer-Tropsch reactor to the thermal conversion plant and recycling at least one of carbon dioxide and tail gas from the Fischer-Tropsch reactor to the thermal conversion plant during gasification.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: August 20, 2013
    Inventor: How Kiap Gueh
  • Preparation of -pyrazine-methylamines
    Patent number: 8513415
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 20, 2013
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Yunyu Mao, Josef A. Rechka, Paula A. Tavares-Greco
  • Substituted imidazole derivatives and methods of use thereof for treating cancer
    Patent number: 8513294
    Abstract: Disclosed are compounds of the general formula (I): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumor tissue growth. These compounds attenuate the oxidative damage associated with increased heme-oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: August 20, 2013
    Assignees: Osta Biotechnologies, Queens University at Kingston, The Sir Mortimer B. Davis-Jewish General Hospital
    Inventors: Ajay Gupta, Hyman M. Schipper, Moulay Alaoui-Jamali, Walter A. Szarek, Kanji Nakatsu, Jason Z. Vlahakis
  • Ester compound and use thereof
    Patent number: 8507692
    Abstract: An ester compound represented by formula (1): wherein R1 represents C1-C4 alkyl, has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: August 13, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Noritada Matsuo
  • N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
    Patent number: 8507541
    Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: August 13, 2013
    Assignee: Incyte Corporation
    Inventors: Andrew P. Combs, Brian M. Glass, Richard B. Sparks, Eddy Wai Tsun Yue
  • Bi-aryl amide compounds as CRTh2 receptor modulators
    Patent number: 8507544
    Abstract: The present invention relates to (2S)-2-({3?-Chloro-4?-[(2,2-dimethylpyrrolidin-1-yl) carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid and (2R)-2-({3?-chloro-4?-[(2,2-dimethylpyrrolidin-1-yl) carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid of formula (I), and crystalline forms and pharmaceutically acceptable salts thereof useful as pharmaceuticals.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: August 13, 2013
    Assignee: Astrazeneca AB
    Inventors: Roger Victor Bonnert, Timothy Jon Luker, Anil Patel, Aaron Rigby
  • Polymerizable monomers
    Patent number: 8501942
    Abstract: A monomer of formula (1) is provided wherein R1 is hydrogen or a monovalent C1-C6 hydrocarbon group, and R2 is a group having polymerization functionality. Using the monomer, crosslinking units can be incorporated into a polymer chain. A chemically amplified negative resist composition comprising a base polymer having crosslinking units incorporated therein has a high sensitivity and forms a resist pattern with minimized LER.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: August 6, 2013
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Daisuke Domon, Satoshi Watanabe
  • Polyethylene and catalyst composition and process for the preparation thereof
    Patent number: 8501884
    Abstract: The invention relates to a bimodal or multimodal polyethylene which comprises ethylene homopolymers and/or copolymers of ethylene with ?-olefins, has a polydispersity index Mw/Mn of the low molecular weight component of less than 10 and can be prepared using a polymerization catalyst based on a Ziegler component and a late transition metal component having a tridentate ligand which bears at least two ortho,ortho-disubstituted aryl radicals and also a catalyst system and a process for preparing the polyethylene and also fibers, moldings, films and polymer blends comprising this material.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: August 6, 2013
    Assignee: Basell Polyolefine GmbH
    Inventors: Shahram Mihan, Harald Schmitz
  • Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators
    Patent number: 8501726
    Abstract: The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: August 6, 2013
    Assignee: Allergan, Inc.
    Inventors: Wenkui K. Fang, Liming Wang, Evelyn G. Corpuz, Ken Chow, Wha Bin Im
  • Pyrrolinone derivative and pharmaceutical composition comprising the same
    Patent number: 8497263
    Abstract: The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3 and/or P2X2/3 receptor antagonist.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 30, 2013
    Assignee: Shionogi & Co., Ltd.
    Inventors: Hiroyuki Kai, Shunji Shinohara, Takayuki Kameyama