Patents Examined by Yong Chu
  • LPA receptor agonists and antagonists and methods of use
    Patent number: 7947665
    Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: May 24, 2011
    Inventors: Duane D. Miller, Gabor Tigyi, Gangadhar G. Durgam, Tamas Virag, Michelle D. Walker, Ryoko Tsukahara
  • Biocompatible fluorescent imaging agents
    Patent number: 7947256
    Abstract: This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: May 24, 2011
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves
  • Crystalline chemotherapeutic
    Patent number: 7947843
    Abstract: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N?-(2-fluoro-5-methylphenyl)urea Hydrate Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: May 24, 2011
    Assignee: Abbott Laboratories
    Inventors: Thomas B. Borchardt, Michael J. Rozema, Shailendra V. Bordawekar, Alexander F. Chu-Kung
  • Preparation of pentafluorosulfanyl (SF) heterocycles: pyrroles and thiophenes
    Patent number: 7943787
    Abstract: The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 17, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Zhaoyun Zheng, William R. Dolbier, Jr.
  • Process for the preparation of almotriptan
    Patent number: 7943784
    Abstract: The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl)1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: May 17, 2011
    Assignee: Matrix Laboratories Limited
    Inventors: Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Ramdas Chavakula, Babu Rao Konudula
  • Crystalline chemotherapeutic
    Patent number: 7943782
    Abstract: N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N?-(2-fluoro-5-methylphenyl)urea Tolueneate Crystalline Form 1, ways to make it and ways to use it are disclosed.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: May 17, 2011
    Assignee: Abbott Laboratories
    Inventor: Rodger F. Henry
  • Process for the preparation of candesartan cilexetil
    Patent number: 7943780
    Abstract: The invention relates to process for the preparation of Candesartan cilexetil. More particularly, it relates to the preparation of pure candesartan cilexetil by the deprotection of Trityl candesartan cilexetil with inorganic acids.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: May 17, 2011
    Assignee: Matrix Laboratories Ltd.
    Inventors: Seeta Ramajaneyulu Gorantla, Mohan Bandari, Nageswara Rao Karusala
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7939556
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: May 10, 2011
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Imidazolidinone and imidazolidinethione derivatives
    Patent number: 7939523
    Abstract: Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: May 10, 2011
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Sheng-Ju Hsu, Yueh Andrew Yueh, Yu-Sheng Chao
  • Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
    Patent number: 7939527
    Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: May 10, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Genesis M. Bacani, Diego Broggini, Eugene Y. Cheung, Christa C. Chrovian, Xiaohu Deng, Laurent Gomez, Cheryl A. Grice, Aaron M. Kearney, Adrienne M. Landry-Bayle, Alice Lee-Dutra, Jimmy T. Liang, Susanne Lochner, Neelakandha S. Mani, Alejandro Santillán, Jr., Kathleen Sappey, Kia Sepassi, Virginia M. Tanis, Alvah T. Wickboldt, John J. M. Wiener, Hartmut Zinser
  • Enzyme inhibitors
    Patent number: 7939666
    Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: May 10, 2011
    Assignee: Chroma Therapeutics Ltd.
    Inventors: Alan Hornsby Davidson, Sanjay Ratilal Patel, Francesca Ann Mazzei, Stephen John Davies, Alan Hastings Drummond, David Festus Moffat, Kenneth William John Baker, Alistair David Graham Donald
  • Imidazole derivatives
    Patent number: 7935707
    Abstract: The invention is concerned with novel imidazole derivatives of formula (I), wherein m, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: May 3, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Alfred Binggeli, Luke Green, Guido Hartmann, Hans P. Maerki, Patrizio Mattei, Fabienne Ricklin, Olivier Roche
  • Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
    Patent number: 7935830
    Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 3, 2011
    Assignee: Athersys, Inc.
    Inventors: Youssef L. Bennani, Bayard Huck, Michael J. Robarge
  • Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
    Patent number: 7935693
    Abstract: Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
    Type: Grant
    Filed: December 29, 2007
    Date of Patent: May 3, 2011
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Jiaxin Yu, Sacha Holland, Jing Zhang, Thilo J. Heckrodt, Pingyu Ding, Joane Litvak
  • Peptide inhibitors of hepatitis C virus replication
    Patent number: 7932277
    Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: April 26, 2011
    Assignees: InterMune, Inc., Array Biopharma Inc.
    Inventors: Scott Seiwert, Steven W. Andrews, Leonid Beigelman, Lawrence M. Blatt, Brad Buckman, Kevin R. Condroski, Yutong Jiang, Robert J. Kaus, April L. Kennedy, Timothy S. Kercher, Michael A. Lyon, Bin Wang
  • Compounds from
    Patent number: 7932285
    Abstract: Compounds isolated from the fruiting body of A. camphorata in a solid culture or pharmaceutically acceptable salts thereof, which exhibit immunostimulatory or anti-inflammatory effects. Also disclosed are methods of stimulating immune responses and/or treating an inflammatory disorder with these compounds or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 26, 2011
    Assignee: Well Shine Biotechnology Development Co., Ltd.
    Inventors: Yueh-Hsiung Kuo, Bi-Fong Lin
  • Fungicide N-cyclopropyl-sulfonylamide derivatives
    Patent number: 7932283
    Abstract: The present invention relates to N-cyclopropyl-sulfonylamide derivatives of formula (I) wherein the substituents are cyclic groups, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions:
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: April 26, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Hans-Georg Schwarz, Sandra Gassmann, Karl-Heinz Kuck, Peter Dahmen, Ulrike Wachendorff-Neumann, Stéphane Carbonne, Stéphanie Gary, Christopher Steele, Alain Villier, Jean-Pierre Vors
  • Thienopyrazole derivative having PDE7 inhibitory activity
    Patent number: 7932250
    Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: April 26, 2011
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hidekazu Inoue, Hidenobu Murafuji, Yasuhiro Hayashi
  • Process for preparing pyrrole derivatives and intermediates
    Patent number: 7932403
    Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: April 26, 2011
    Assignee: ratiopharm GmbH
    Inventors: Pavel Bobal, Jaroslav Frantisek, Jiri Stohandl, Kane Denike, Armin Boerner, Vitali Tararov, Andrei Korostylev, Gerd Koenig, Nicolas Jeker
  • Imidazolidine carboxamide derivatives as P2X7 modulators
    Patent number: 7932282
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: April 26, 2011
    Assignee: Glaxo Group Limited
    Inventors: Paul John Beswick, David Kenneth Dean, Robert James Gleave, Andrew Peter Moses, Daryl Simon Walter