Abstract: Methods and compositions for preventing or treating cognitive decline associated with dementia and/or mild cognitive impairment and/or neurodegeneration using antibodies, peptides, fusion proteins, or genome editing systems that modulate HSPG/heparin binding affinities of ApoE.

Abstract: The invention relates to Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) antagonists, such as antibodies and fragments, as well as methods, uses and combinations.

Abstract: Systems involving distributed control functions are described herein. Each member or device within the system has responsibility for controlling part of the system's behavior, and includes logic to determine what action, if any, will follow as a response to determining information or receiving information from other members or devices within the system. A change of status of one member of a system may provide a basis for action by another member of the system. Status may be the result of sensing a condition of the environment, sensing the condition of a component, receiving the output of a conventional sensor, and/or sensing the condition of a link between components. In some embodiments, action taken by a member of the system may include collecting data during law enforcement activities.

Abstract: Apparatuses and methods for coupling semiconductor devices are disclosed. In a group of semiconductor devices (e.g., a stack of semiconductor devices), a signal is provided to a point of coupling at an intermediate semiconductor device of the group, and the signal is propagated away from the point of coupling over different (e.g., opposite) signal paths to other semiconductor devices of the group. Loading from the point of coupling at the intermediate semiconductor device to other semiconductor devices of a group may be more balanced than, for example, having a point of coupling at semiconductor device at an end of the group (e.g., a lowest semiconductor device of a stack, a highest semiconductor device of the stack, etc.) and providing a signal therefrom. The more balanced topology may reduce a timing difference between when signals arrive at each of the semiconductor devices.

Abstract: Some embodiments are directed to obtaining computer network connection data of the client-side transaction entry program, the computer network connection data allowing a connection to be made with the client-side transaction entry program, receiving a begin transaction message from the client-side computer indicating a request to launch a transaction, the computer network connection data being obtained before receiving the begin transaction message, and setting up a connection between the transaction system and the client-side transaction entry program using the computer network connection data enabling the client-side transaction entry program and the transaction system to cooperate in performing the transaction.

Abstract: Certain aspects of the present disclosure provide techniques for collision mitigation in sidelink. A method that may be performed by a user equipment (UE) includes measuring channel busy ratio (CBR), estimating a number of UEs using the channel, estimating a congestion level based on the CBR and the estimated number of UEs. A method that may be performed by a sidelink UE includes determining a semi-persistent scheduling (SPS) resource reservation including first subframes, determining second subframes for generated packet transmission, determining to skip transmission in the second subframes, listening during the second subframes for another sidelink UE's transmission, and determining whether to reselect resources. Another method includes listening during a first subframe for another sidelink UE's transmission, detecting the transmission collides with a scheduled transmission resource for the sidelink UE based on an amount of frequency resource overlap, and determining to reselect resources.

Abstract: A method of rendering, in a rendering space, a scene formed by primitives in a graphics processing system. A rendering phase receives data describing one or more primitives and one or more associated fragment shading rates to be used during rendering. Fragments for the one or more primitives corresponding to sample positions of the one or more primitives within a region of the rendering space are stored in a buffer sampler. The buffer is parsed to produce microtiles, each microtile corresponding to an array of sample positions within the region and containing sampler fragments from the one or more primitives, the microtiles are analysed to identify shader fragment task instances to be shaded, and the shader fragment task instances are arranged into blocks, wherein at least one block of shader fragment task instances comprises shader fragment task instances from more than one microtile. The blocks of shader fragment task instances are shaded.

Abstract: A kit for an adjustable stimulator for male genitalia comprises a cylindrical core having a cylindrical axis and an opening on its surface, a vibratory module having at least one vibrating unit thereon, a mount for mounting the vibratory module on the interior of the core, and a plurality of penetration lips for application to a selected end of the core, each of the plurality of lips having an annular opening of differing diameters, whereby a user is able to configure the stimulator to accommodate the dimensions of the user's erection.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: Disclosed are a data flow table for high-speed large-scale concurrent data flows, method and apparatus for processing the data flow table, and a storage medium. The method includes: acquiring, according to a data flow identifier of a data flow to be inserted, addresses of candidate buckets in a fingerprint table and a data flow fingerprint; detecting whether there is an idle unit in the candidate buckets in the fingerprint table, if there is an idle unit, selecting the candidate bucket having the idle unit as target bucket; and sequentially searching for the idle unit from bottom unit to top unit of the target bucket, and when the idle unit is found in the target bucket, writing data flow fingerprint of said data flow into the found idle unit, and writing data flow record of said data flow into a recording bucket corresponding to the candidate bucket.

Abstract: The invention relates to: a composition for culturing natural killer cells, comprising, as an active ingredient, a fusion protein comprising an IL-2 protein and a CD80 protein; and a method for preparing natural killer cells by using same. Particularly, a composition for culturing natural killer cells, comprising, as an active ingredient, a fusion protein comprising IL-2 or a variant thereof and CD80 or a fragment thereof, of the present invention; promotes the proliferation of natural killer cells, induces the expression of CD16 and NKp46, and increases the expression and secretion of granzyme B and perforin, thereby being effectively usable in the preparation of natural killer cells having an excellent anticancer immune function.

Abstract: An exoskeleton network. The exoskeleton network includes an exoskeleton system that has one or more sensors and a memory; a user device that is local to the exoskeleton system and that operably communicates with the exoskeleton system; and a classification server that operably communicates with at least one of the exoskeleton system and the user device. The exoskeleton network performs feature extraction on sensor data obtained from the one or more sensors to generate feature-extracted sensor data and performs label derivation on the feature-extracted sensor data to generate labeled sensor data.

Abstract: The invention relates to peptides capable of inhibiting neuronal exocytosis and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions, disorders and/or diseases mediated by neuronal exocytosis, such as wrinkles, excessive perspiration, pruritus, cutaneous inflammation, dermatitis, atopia, psoriasis, vascular hyperreactivity, rosacea, acne, hair growth, wound healing, calluses, warts, or sensitive skin conditions, such as ulcers and lesions on the skin.

Abstract: The present inventive concept relates to a substrate processing apparatus comprising: a chamber; a substrate support part which supports one or more substrates in the chamber; an upper electrode which is disposed above and arranged opposite to the substrate support part; and a lower electrode which is disposed below and spaced apart from the upper electrode, wherein the lower electrode includes a first electrode to which first RF power having a first frequency is applied and a second electrode to which second RF power having a second frequency different from the first frequency is applied.

Abstract: The present invention provides an anti-TIGIT immunosuppressant and use thereof. The immunosuppressant can bind to the extracellular region of human TIGIT, and can be used for treating diseases such as a cancer.

Abstract: In a semiconductor device according to the present disclosure, one end and the other end of a plurality of insulation covering wires are joined to a connection region in an upper electrode of a DBC substrate over a semiconductor element while an insulation covering portion in a center region has contact with a surface of the semiconductor element. The plurality of insulation covering wires are provided along an X direction in the same manner as the plurality of metal wires. The plurality of insulation covering wires are provided with no loosening, thus have press force of pressing the semiconductor element in a direction of the solder joint portion.

Abstract: An antenna adaptation is provided for a communication node as controlled by an antenna adaptation command. The antenna adaptation command adjusts the number of active transmit antennas and/or the number of active receive antennas in the communication node such as for reducing interference at the communication node.

Abstract: A first set of subconditions is obtained. Approximate matching of the first set of subconditions against a plurality of sets of subconditions is performed. A second set of subconditions among the plurality of sets of subconditions is accessed, wherein a representation of a subcondition in the first set and/or the second set of subconditions comprises a value having one of a plurality of states, and wherein the plurality of states comprises a state of “don't care”. The first set of subconditions is approximately matched against the second set of subconditions. The first set of subconditions is compared against the second set of subconditions. A matching criterion is determined to be met based on a result of the matching. Information indicating that the second set of subconditions is at least an approximate match for the first set of subconditions is output.

Abstract: Various aspects of the present disclosure generally relate to signaling in frame-based equipment (FBE) mode for channel occupancy time (COT) sharing. In some aspects, a user equipment (UE) may receive, in association with an FBE mode, a message associated with a designation of the UE for either COT sharing or non-COT sharing. The UE may detect whether there is an initial signal at a boundary of a time frame for COT and sleep, monitor, or communicate during the time frame, based at least in part on the designation and the detecting. Numerous other aspects are provided.