Patents Examined by Yvonne (Bonnie) Eyler
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Patent number: 7510825Abstract: The present invention provides kits and in vitro, in vivo or ex vivo detection methods by using compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their cell membranes, such as cells undergoing apoptosis, while binding to a lesser degree to normal cells.Type: GrantFiled: July 5, 2005Date of Patent: March 31, 2009Assignee: NST NeuroSurvival Technologies LtdInventors: Ilan Ziv, Anat Shirvan
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Patent number: 7435814Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.Type: GrantFiled: December 8, 2005Date of Patent: October 14, 2008Assignee: Rigel Pharmaceuticals, Inc.Inventors: Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha J. Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B. Rossi
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Patent number: 7425656Abstract: Provided are a catalyst composition including a transition metal catalyst and a nitrogen-containing bidentate phosphorus compound and a process for hydroformylation reaction of olefins to prepare aldehydes which includes stirring the catalyst composition, an olefin compound, and a gas mixture of of carbon monoxide and hydrogen, under high temperature and pressure condition. Therefore, very high catalytic activity and high selectivity in normal-aldehyde or iso-aldehyde according to the type of a substiuent are ensured.Type: GrantFiled: September 15, 2005Date of Patent: September 16, 2008Assignee: LG Chem, LtdInventors: You Moon Jeon, Donghyun Ko, Sungshik Eom, O Hak Kwon, Jaehui Choi
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Patent number: 7393980Abstract: The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.Type: GrantFiled: May 16, 2002Date of Patent: July 1, 2008Assignee: Rhodia ChimieInventors: Maxime Garayt, Virginie Le Boulaire, Danielle Gree, René Gree, Vincent Schanen, Jean-Francis Spindler
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Patent number: 7388110Abstract: A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.Type: GrantFiled: July 25, 2005Date of Patent: June 17, 2008Assignee: Terumo Kabushiki KaishaInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Patent number: 7385087Abstract: A process for preparing ?-(3-arylthio)acetophenones of the general formula I where the substituents R1 and R2 are each independently C1-C6-alkyl or an optionally substituted phenyl or benzyl radical, which comprises A) reacting acetophenones of the general formula II where the substituent R1 is as defined above with sulfuryl chloride and subsequently hydrolyzing, and B) reacting the reaction mixture obtained in this way with a thiophenol of the general formula III where the substituent R2 is as defined aboveType: GrantFiled: February 20, 2004Date of Patent: June 10, 2008Assignee: BASF AktiengesellschaftInventors: Marco Altmayer, Wolfgang Siegel
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Patent number: 7384580Abstract: The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.Type: GrantFiled: April 1, 2005Date of Patent: June 10, 2008Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Paul Knochel, Arkady Krasovskiy
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Patent number: 7381846Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: July 25, 2007Date of Patent: June 3, 2008Assignee: IM&T Research, Inc.Inventors: Teruo Umemoto, Rajendra P. Singh
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Patent number: 7378556Abstract: Disclosed is a process for making a thiophosphine compound of formula (I): wherein X represents SH or with R1 being H or —CH3, R and R? represent, independently from each other, an alkyl radical, an alkoxy radical, an aryl radical or a phenyl radical which may be substituted with one or more alkyl and/or alkoxy groups, n is an integer from 0 to 4, n? is an integer from 0 to 5, x is an integer from 0 to 2, y is an integer from 1 to 5 with the proviso that y+n is an integer from 1 to 5, wherein y =1, X is in para position with regard to phosphorus and represents SH.Type: GrantFiled: October 20, 2006Date of Patent: May 27, 2008Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Sirisoma Wanigatunga, Aref Jallouli, Martin Rickwood, Yassin Yusef Turshani
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Patent number: 7375251Abstract: The present invention provides processes and intermediates for the preparation of aminoethoxybenzyl alcohols of Formula I useful in the production of pharmaceutically useful compoundsType: GrantFiled: January 11, 2006Date of Patent: May 20, 2008Assignee: WyethInventors: Pietro Allegrini, Giuseppe Barreca, Giorgio Soriato
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Patent number: 7365198Abstract: Provided is an organic light emitting device capable of emitting light with high efficiency by incorporating a silyl compound in which a silyl group is directly bonded to an anthracene ring particularly into its light emitting layer.Type: GrantFiled: February 22, 2007Date of Patent: April 29, 2008Assignee: Canon Kabushiki KaishaInventors: Akihito Saitoh, Masataka Yashima
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Patent number: 7361786Abstract: The present invention relates to ligands of the general formula (I). In addition, a process for the production thereof and the use thereof are demonstrated.Type: GrantFiled: December 12, 2006Date of Patent: April 22, 2008Assignee: Degussa AGInventors: Armin Boerner, Jens Holz, Axel Monsees, Thomas Riermeier, Renat Kadyrov, Carsten A. Schneider, Uwe Dingerdissen, Karlheinz Drauz
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Patent number: 7351847Abstract: Three improved Grignard processes are used for preparing phenyl-containing chlorosilane products wherein the yield of diphenylchlorosilanes as a product is maximized, while the yield of phenylchlorosilanes as a product is minimized. In one embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent and a trichlorosilane. In another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, a trichlorosilane, and a phenylchlorosilane. In yet another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, and a phenylchlorosilane. In each embodiment, the reactants are present in particular mole ratios of the components.Type: GrantFiled: December 17, 2004Date of Patent: April 1, 2008Assignee: Dow Corning CorporationInventor: Binh Thanh Nguyen
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Patent number: 7348303Abstract: A quaternary ammonium composition is claimed which essentially consists of a) a cationic compound with general formula: wherein R1 is C8-C22-alkyl, C8-C22-alkenyl, C8-C22-alkylamidopropyl, C8-C22-alkenyl-amidopropyl, C8-C22-alkyl/alkenyl(poly)alkoxyalkyl, C8-C22-alkanoylethyl or C8-C22-alkenoylethyl, R2, R3 and R4 are C1—C22-alkyl, C2-C22-alkenyl or a group of the formula -A-(OA)n-OH, A is —C2H4— and/or —C3H6—, n is a number from 0 to 20 and X is an anion, b) water and c) a non-ionic solvent of the general formula R—O-(AO)nH, where R is hydrogen, alkyl or alkenyl containing 8 to 22 carbon atoms, or phenyl, A is C2H4 and/or C3H6 and n is a number from 0 to 20, which composition is characterized in that it contains less than 20% by weight of water.Type: GrantFiled: November 26, 2003Date of Patent: March 25, 2008Assignee: Clariant International, Ltd.Inventors: Manlio Gallotti, Patricia Ramos Pereira De Moraes, Cássio Queiroz Cavalcante
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Patent number: 7345185Abstract: The present invention relates to a process for preparing organophosphites, organosphonites and organophosphinites by condensing phosphorus trihalides or organophosphorus halides with organic compounds bearing hydroxyl groups in the presence of polymeric basic ion exchange resins. The process according to the invention makes possible in a simple manner the preparation of trivalent organophosphorus compounds which may serve, for example, as ligands in rhodium complexes which may be used as a catalyst in hydroformylation.Type: GrantFiled: October 27, 2004Date of Patent: March 18, 2008Assignee: OXENO Olefinchemie GmbHInventors: Dagmara Ortmann, Klaus-Diether Wiese, Oliver Moeller, Dirk Fridag
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Patent number: 7342061Abstract: The invention relates to a method for producing novel reactive organic compounds containing poly-DOPO and having a higher phosphorus content than known comparable DOPO (9,10-dihydro-9-oxa-10-phospha-phenenthrene-10-oxide) adducts, and to the use thereof for flameproofing thermoplastic polymers, such as polyesters and polyamides. The same flameproofing effect is achieved with smaller additive quantities than previously, thus reducing the influence of the physical, especially textile-physical properties of the polymers. The adducts containing poly-DOPO are formed by reacting DOPO with acetylenes carrying reactive groups, in the presence of a catalyst.Type: GrantFiled: June 18, 2003Date of Patent: March 11, 2008Assignee: Thueringisches Institut f{umlaut over ())}{umlaut over (})}r Textil-und Kunstsoff-Forschung e.V.Inventors: Wolfgang Mueller, Erich Meusel, Klaus Heinemann, Eberhard Taeger
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Patent number: 7339070Abstract: A method for recovering a product mixture from a waste stream in a diaryl carbonate manufacturing process comprising reacting the waste stream with an alkyl alcohol to form a reaction mixture, and separating the product mixture from the reaction mixture.Type: GrantFiled: May 15, 2006Date of Patent: March 4, 2008Assignee: General Electric CompanyInventors: Vutukuru Lakshmi Narasimha Murthy, Ignacio Vic Fernandez, Venugopal Boddapaty Venkata
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Patent number: 7338669Abstract: The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture therapy of cancer, and as synthetic building blocks in the synthesis of boranonucleotides of various lengths.Type: GrantFiled: February 2, 2005Date of Patent: March 4, 2008Assignee: Bar-Ilan UniversityInventors: Bilha Fischer, Victoria Nahum
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Patent number: 7339081Abstract: A process for preparing bromo-1-oxypentafluorosulfanylbenzene is provided, the process including the step of brominating pentafluorosulfanyloxybenzene with a bromination agent to provide the bromo-1-oxypentafluorosulfanylbenzene. The process is more effective than prior art processes for preparing such compounds.Type: GrantFiled: July 10, 2006Date of Patent: March 4, 2008Assignee: Air Products and Chemicals, Inc.Inventors: Robert George Syvret, Gauri Sankar Lal
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Patent number: 7335797Abstract: This invention refers to a process for the synthesis of cumene hydroperoxide and to the product thus obtained. More in particular, this invention refers to a process for the production of cumene hydroperoxide by oxidating cumene with oxygen, where this process is run in the presence of a basic medium insoluble in the reaction environment, and such as not to release inorganic cations to the reaction environment. Such a basic medium is preferably a pyridinic resin. The cumene hydroperoxide thus obtained, characterized by the fact of being free of inorganic cations, is a further object of the invention.Type: GrantFiled: March 14, 2002Date of Patent: February 26, 2008Assignee: Eurotechnica Development & Licensing S.p.A.Inventor: Franco Codignola