Patents Examined by Yvonne Pyla
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Patent number: 10751276Abstract: The present invention relates to a composition comprising ex-vivo expanded adipose tissue derived stem cell (ASC) or ex-vivo expanded adipose tissue-derived stem cells (ASC) mixed with harvested fat tissue at a ratio of 5.0×104-2.0×108ASCs/mL fat; for example 1.0×105-2.0×107 and the use of ex-vivo expanded adipose tissue-derived stem cells or ex-vivo expanded adipose tissue-derived stem cell enriched fat grafts as an agent for cosmetic breast filling/augmentation or for facial filling/reju-venation.Type: GrantFiled: June 26, 2014Date of Patent: August 25, 2020Assignee: STEMFORM APSInventor: Stig-Frederik Trojahn Kølle
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Patent number: 9932545Abstract: A peanut food product with reduced levels of allergenic proteins such as Ala h1/h2/h3 is produced by initiating the germination process in raw peanuts, holding the peanuts in moist conditions to initiate germination, and then treating with bromelain.Type: GrantFiled: April 15, 2015Date of Patent: April 3, 2018Assignee: Molecular Epidemiology Inc.Inventor: Mansour Samadpour
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Patent number: 9856438Abstract: A peanut food product with reduced levels of allergenic proteins such as Ala h1/h2/h3 is produced by initiating the germination process in raw peanuts, holding the peanuts in moist conditions to initiate germination and then treating with bromelain.Type: GrantFiled: February 25, 2013Date of Patent: January 2, 2018Assignee: Molecular Epidemiology Inc.Inventor: Mansour Samadpour
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Patent number: 9840745Abstract: A variety of products may incorporate cultured leather, which is produced in vitro. Examples of products that may incorporate cultured leather include footwear, apparel, athletic equipment, furniture, handbags or any other consumer or industrial product that commonly incorporates conventional leather or synthetic leather.Type: GrantFiled: February 28, 2014Date of Patent: December 12, 2017Assignee: NIKE, Inc.Inventor: Pamela S. Greene
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Patent number: 9814803Abstract: There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.Type: GrantFiled: October 12, 2015Date of Patent: November 14, 2017Assignee: ALLOSOURCEInventor: Yaling Shi
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Patent number: 9808558Abstract: There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.Type: GrantFiled: October 12, 2015Date of Patent: November 7, 2017Assignee: AlloSourceInventor: Yaling Shi
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Patent number: 9801975Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.Type: GrantFiled: September 18, 2015Date of Patent: October 31, 2017Assignee: AlloSourceInventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
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Patent number: 9801976Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.Type: GrantFiled: September 18, 2015Date of Patent: October 31, 2017Assignee: AlloSourceInventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
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Patent number: 9795088Abstract: A self-supporting composite material is made with a shape conforming to the shape of an enclosure within which the composite material is incubated and molded. In on embodiment, a lid with at least one extrusion is placed over the enclosure to form a void in the final product corresponding to the extrusion. In another embodiment, a tool with extruded features is pressed into a face of the product in the enclosure to mold features into the finished product.Type: GrantFiled: November 18, 2013Date of Patent: October 24, 2017Assignee: Ecovative Design LLCInventors: Eben Bayer, Gavin McIntyre, Burt L. Swersey
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Patent number: 9765301Abstract: The invention relates to a liver organoid, uses thereof and method for obtaining them.Type: GrantFiled: July 29, 2011Date of Patent: September 19, 2017Assignee: Koninklijke Nederlandse Akademie van WetenschappenInventors: Meritxell Huch Ortega, Johannes Carolus Clevers
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Patent number: 9763984Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.Type: GrantFiled: December 21, 2013Date of Patent: September 19, 2017Assignee: Astellas Institute for Regenerative MedicineInventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
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Patent number: 9744266Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.Type: GrantFiled: September 18, 2015Date of Patent: August 29, 2017Assignee: AlloSourceInventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
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Patent number: 9687511Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.Type: GrantFiled: April 9, 2015Date of Patent: June 27, 2017Assignee: Vivex Biomedical, Inc.Inventors: Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaëtan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito, Timothy Ganey
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Patent number: 9675644Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.Type: GrantFiled: March 25, 2016Date of Patent: June 13, 2017Assignee: Vivex Biomedical, Inc.Inventors: Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaëtan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito, Timothy Ganey
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Patent number: 9675643Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.Type: GrantFiled: April 10, 2015Date of Patent: June 13, 2017Assignee: Vivex Biomedical, Inc.Inventors: Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaëtan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito, Timothy Ganey
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Patent number: 9670443Abstract: A method of forming an implantable tissue engineered construct, a bioreactor for forming a tissue engineered construct, and a tissue engineered construct itself are disclosed The method includes seeding a scaffold with cells to form a tissue construct; locating the tissue construct in a space defined by a tissue construct support element; locating the tissue construct support element within a bioreactor; and operating a load applicator of the bioreactor to apply a cyclical compressive mechanical load to the tissue construct, to stimulate the deposition of tissue matrix in the tissue construct, in which the tissue construct, the tissue construct support element and the load applicator are arranged so that the load applicator can at least initially contact both the tissue construct and the tissue construct support element, so that at least part of a total load generated by the load applicator is borne by the tissue construct support element.Type: GrantFiled: June 25, 2014Date of Patent: June 6, 2017Assignees: UNIVERSITY OF LEEDS, XIROS LIMITEDInventors: Scott Finlay, Bahaa Botros Seedhom
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Patent number: 9637770Abstract: Provided is a biosensor including a scaffold and a dye complex, the dye complex including a clay material associated with a dye material, where the dye complex is at least partially embedded in the scaffold. Also provided is a process for preparing the biosensor, an apparatus including the biosensor and methods for detecting viable microorganisms in an aqueous fluid test sample making use of the biosensor, for predicting biofouling in a fluid flowing system and for determining a concentration of disinfectant required to disinfect an aqueous fluid.Type: GrantFiled: March 7, 2012Date of Patent: May 2, 2017Assignee: MEKOROT WATER COMPANY, LTD.Inventors: Eli Kotzer, Robert Armon
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Patent number: 9623042Abstract: The invention relates to a combination preparation for improving the sperm quality and capacitation of a male individual. Said combination preparation comprises effective amounts of L-carnitine, coenzyme Q10, at least one vitamin E, particularly ?-tocopherol, at least one source of zinc, especially zinc sulfate or zinc chloride, at least one source of vitamin B, particularly folic acid, at least one source of selenium, glutathione, and arginine or salts or derivatives thereof as active substances.Type: GrantFiled: February 5, 2007Date of Patent: April 18, 2017Assignee: Fapa Vital AnstaltInventor: Brigitte Annerl
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Patent number: 9611177Abstract: Microcapsules for inclusion in concrete are disclosed. The microcapsules are adapted to reduce the area of defects in the concrete. The microcapsules may include carbonatogenic bacteria spores in a liquid core, contained in a polymer layer. Also disclosed are concrete compositions including the microcapsules.Type: GrantFiled: August 8, 2013Date of Patent: April 4, 2017Assignees: UNIVERSITEIT GENT, DEVAN CHEMICALS NVInventors: Hugo Soens, Nele De Belie, Jianyun Wang, Maxime Durka
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Patent number: 9581587Abstract: A method of sex sorting sperm is disclosed. The sperm may be stained with a DNA selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the DNA selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye. The stained sperm may then sorted into one or more gender enriched subpopulations of viable sperm.Type: GrantFiled: September 28, 2012Date of Patent: February 28, 2017Assignee: Inguran, LLCInventors: Kenneth Michael Evans, Thomas B. Gilligan, Clara Gonzalez-Marin