Abstract: The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in therapeutic, vaccine, and diagnostic applications. The invention is also directed to HCV vectors, e.g., for gene therapy of gene vaccines.
Type:
Grant
Filed:
November 6, 2003
Date of Patent:
June 26, 2007
Assignee:
Washington University
Inventors:
Charles M. Rice, Alexander A. Kolykhalov