Patents Examined by Zachary J Miknis
  • Hypersensitive response elicitor peptides and use thereof
    Patent number: 10897900
    Abstract: Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: January 26, 2021
    Assignee: PLANT HEALTH CARE, INC.
    Inventors: Zhongmin Wei, Gregory A. Zornetzer
  • Topical agent for transdermal administration
    Patent number: 10894009
    Abstract: The present invention aims to provide a cyclosporine external preparation showing improved transdermal absorbability of cyclosporine. The present invention provides an external preparation containing cyclosporine and a ketone.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: January 19, 2021
    Assignee: MARUHO CO., LTD.
    Inventors: Hiroki Sakiyama, Noriaki Kaneda, Tomomi Shigeno
  • Multi-factor hair growth formulation
    Patent number: 10894074
    Abstract: A synergistic, multi-factor hair growth formulation and its method of use are described. A plurality of synthetic peptides and proteins are selected to maximize efficacy at discrete stages of the anagenic growth phase of a hair follicle, and these compounds may be further coated to promote uptake into the skin and/or hair root. The formulation itself is topical, so as to allow for direct, selective application alone or in combination with mechanical or energetic delivery techniques.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: January 19, 2021
    Assignee: SKINQRI, LLC
    Inventor: James Bartholomeusz
  • Polypeptide ligands specific for plasma kallikrein
    Patent number: 10894808
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are specific for the human and rat protease plasma kallikrein and are modified in one or two peptide loops to enhance potency and/or protease resistance.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: January 19, 2021
    Assignee: BicycleRD Limited
    Inventors: Daniel Teufel, Catherine Stace, Edward Walker
  • Process for extracting materials from biological material
    Patent number: 10865334
    Abstract: The invention is directed to a process for extracting materials from biological material, which process is characterized in that the naturally occurring biological material is treated with an extractant consisting of a deep eutectic solvent of natural origin or a an ionic liquid of natural origin to produce a biological extract of natural origin dissolved in the said solvent or ionic liquid.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: December 15, 2020
    Assignee: Universiteit Leiden
    Inventors: Jacob van Spronsen, Geert-Jan Witkamp, Frank Hollman, Young Hae Choi, Robert Verpoorte
  • Hypersensitive response elicitor peptides and use thereof
    Patent number: 10856547
    Abstract: Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: December 8, 2020
    Assignee: PLANT HEALTH CARE, INC.
    Inventors: Zhongmin Wei, Gregory A. Zornetzer
  • Hypersensitive response elicitor peptides and use thereof
    Patent number: 10856546
    Abstract: Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: December 8, 2020
    Assignee: PLANT HEALTH CARE, INC.
    Inventors: Zhongmin Wei, Gregory A. Zornetzer, Stephen Bornick
  • Modulators of complement activity
    Patent number: 10835574
    Abstract: The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: November 17, 2020
    Assignee: RA PHARMACEUTICALS, INC.
    Inventors: Steven James DeMarco, Michelle Denise Hoarty, Grace Victoria Parker, Alonso Ricardo, Sylvia Tobe, Douglas A. Treco
  • Amino acid-specific binder and selectively identifying an amino acid
    Patent number: 10836798
    Abstract: An amino acid-specific binder selectively binds to a binding amino acid. A binder complex selectively identifies the binding amino acid and includes an adjunct attached to the amino acid-specific binder. The adjunct includes a taggant, protein, substrate, or chemical modifier. Selectively identifying an N-terminal amino acid includes anchoring a C-terminal end; contacting an N-terminal amino acid of the anchored analyte with the binder complex; selectively binding when the N-terminal amino acid includes the binding amino acid; producing, by the taggant of the tagged complex, a taggant signal; detecting the taggant signal; and identifying the N-terminal amino acid based on the taggant signal.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: November 17, 2020
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Jennifer A. Tullman, Zvi Kelman, John P. Marino
  • Conjugates of islet neogenesis peptides and analogs, and methods thereof
    Patent number: 10829527
    Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: November 10, 2020
    Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.
    Inventors: Liping Liu, Ru Bai
  • Modified anti-inflammatory proteins and method of use
    Patent number: 10822395
    Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: November 3, 2020
    Inventors: Alex Loukas, Andrew Leech, Darren Pickering
  • Hypersensitive response elicitor-derived peptides and use thereof
    Patent number: 10793608
    Abstract: Disclosed are hypersensitive-response eliciting peptides and non-hypersensitive response eliciting peptides that induce active plant responses, and that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 6, 2020
    Assignee: PLANT HEALTH CARE, INC.
    Inventors: Zhongmin Wei, Gregory A. Zornetzer
  • Method for treating cancer
    Patent number: 10786544
    Abstract: The present disclosure relates to a method of treating prostate cancer comprising administering to a subject in need thereof a therapeutically effective amount of a vasopressin analogue.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: September 29, 2020
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Laurence H. Klotz, Vasundara Venkateswaran
  • Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof
    Patent number: 10774110
    Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 15, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jun Liu, Jingxin Wang, Zhaoli Sun, Sam Hong
  • Isolating traffic-enhancing mutants of drug delivery protein
    Patent number: 10752893
    Abstract: The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an organelle, comprising a polypeptide encoded by a mutant penton base gene. In another embodiment, the invention provides a method of enhancing trafficking to a cell by administering a composition comprising a penton base (PB) protein with one or more mutations that enhance cellular entry.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: August 25, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventor: Lali K. Medina-Kauwe
  • Chimeric inhibitor molecules of complement activation
    Patent number: 10752661
    Abstract: The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: August 25, 2020
    Assignee: Omeros Corporation
    Inventors: Peter Garred, Tina Hummelshoj Glue, Mikkel-Ole Skjodt
  • Methods and compositions for the prevention and treatment of disease
    Patent number: 10744178
    Abstract: The present technology is directed to compositions and methods for preventing, ameliorating, or reducing the severity of one or more signs, or symptoms associated with a reduction of function, decreased expression level of, and/or deficiency in one or more of COL4A3, COL4A4 and COL4A5 genes. Also disclosed herein are methods of preventing or treating Alport Syndrome in a mammalian subject, reducing risk factors associated with Alport Syndrome, and/or reducing the likelihood or severity of Alport Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 18, 2020
    Assignee: Stealth BioTherapeutics Corp
    Inventor: D. Travis Wilson
  • Elicitor peptides having disrupted hypersensitive response box and use thereof
    Patent number: 10743538
    Abstract: Disclosed are peptides that induce an active plant response, but not a hypersensitive response, when applied to plant tissue. These peptides also preferably exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 18, 2020
    Assignee: Plant Health Care, Inc.
    Inventors: Zhongmin Wei, Gregory A. Zornetzer
  • Therapy and kit for the prevention and treatment of cystic fibrosis
    Patent number: 10744180
    Abstract: Compositions, kits and methods for preventing or treating cystic fibrosis are provided, which include the use of a peptidomimetic that inhibits the interaction between CAL and mutant CFTR proteins.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: August 18, 2020
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Dean R. Madden, Nicholas P. Gill, Carrie Ann Davison, Mark R. Spaller
  • Fluorocarbon-linked peptide formulation
    Patent number: 10729759
    Abstract: The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: August 4, 2020
    Assignee: Altimmune UK Limited
    Inventors: Carlton Bradley Brown, Bertrand Victor Gilbert Georges, Jean Francois Thaburet