Patents Examined by Zachary Tucker
  • Patent number: 7855208
    Abstract: This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: December 21, 2010
    Assignee: NeuroSearch A/S
    Inventors: Dan Peters, Daniel B. Timmermann, Gunnar M. Olsen, Elsebet Ostergaard Nielsen
  • Patent number: 7329668
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: February 12, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yuping Qiu, Makonen Belema, Xuejie Yang, Fred Christopher Zusi, William J. Pitts
  • Patent number: 7186832
    Abstract: The present invention relates to substituted imidazopyrazines of the general Formula I which modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: March 6, 2007
    Assignee: Sugen Inc.
    Inventors: Connie Li Sun, Congxin Liang, Ping Huang, G. Davis Harris, Jr., Huiping Guan
  • Patent number: 7105506
    Abstract: Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: September 12, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Patent number: 6833471
    Abstract: A methods for producing a hydroxy-amino acid or derivative thereof, such as statine, phenylstatine or isostatine, is provided. A substituted &bgr;-ketodiester having a ketone group and two ester functional groups is contacted with a ketoreductase under conditions permitting the reduction of the ketone group to an alcohol. Only one of the ester functional groups is regioselectively hydrolyzed to the corresponding carboxylic acid, whereby a non-hydrolyzed ester functional group remains. Either the carboxylic acid or the non-hydrolyzed ester functional group is converted to an amine or a derivative thereof to produce a hydroxy-amino acid or derivative thereof.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: December 21, 2004
    Assignee: BioCatalytics, Inc.
    Inventors: J. David Rozzell, Jr., Spiros Kambourakis
  • Patent number: 6759550
    Abstract: The present invention pertains to an improved method of oxidizing substituted aromatic compounds (such as p xylene) to their corresponding aromatic acids (such as terephthalic acid). The improvement involves carrying out the oxidation reaction in an aqueous medium, wherein the aqueous medium contains at least 30 percent water, preferably up to 30 percent surfactant and preferably a low molecular weight material containing a hydrophilic end group as a co-surfactant. The reaction is carried out at a pH of less than 3.0.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: July 6, 2004
    Assignee: The Dow Chemical Company
    Inventors: John Klier, Christopher J. Tucker, Thomas H. Kalantar, Kenneth A. Burdett, Daniel Patrick Green, Luciano Piras, Sergio Schena, Guo-shuh John Lee
  • Patent number: 6506932
    Abstract: A method for oxidizing an aromatic compound possesssing at least one alkyl substituent by using a catalyst avoids containing a corrosive bromine ion, remains stably without being decomposed even in an oxidizing atmospherfe, and permits reclamation is provided. An aromatic compound possessing at least one alkyl substituent is oxidized by using a catalyst which has at least one kind of element selected from the group consisting of phosphorus, silicon, and germanium as a hetero atom and at least one kind of element selected from the group consisting of molybdenum, tungsten, vanadium, and niobium as a poly atom and comprises a heteropoly-oxometalate anion possessing two defective structure site and at least one kind of element selected from the group of elements of Periods 4˜6 of Groups IB, VA,VIIA, and VIII in the Periodic Table of the Elements.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: January 14, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yasutaka Sumida, Masahiro Wada, Noritaka Mizuno
  • Patent number: 6476076
    Abstract: The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 5, 2002
    Assignees: Pacific Corporation, Digital Biotech Co., Ltd.
    Inventors: Jeewoo Lee, Uhtaek Oh, Young-Ho Park, Young-Ger Suh, Hyeung-Geun Park, Hee-Doo Kim
  • Patent number: 6458989
    Abstract: A process for preparing pure (meth)acrylic acid or a (meth)acrylate starting from a crude (meth)acrylic acid, which comprises the following stages: A: treating the crude (meth)acrylic acid with at least one compound which is able to remove aldehydes, to give an aldehyde-free crude (meth)acrylic acid; B: subjecting the aldehyde-free crude (meth)acrylic acid to imprecise distillation, to give a low-boiling fraction comprising (meth)acrylic acid and acetic acid and a high-boiling fraction comprising (meth)acrylic acid and high boilers; C: isolating a pure (meth)acrylic acid from the high-boiling fraction and, if desired, D: esterifying the low-boiling fraction comprising (meth)acrylic acid and acetic acid that is obtained in stage B by means of one or more alkanols, to give an esterification mixture comprising one or more (meth)acrylates, one or more acetic esters, and one or more alkanols.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: October 1, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinrich Aichinger, Hans Martan, Gerhard Nestler
  • Patent number: 6458994
    Abstract: A process for producing a polycarboxylic acid which comprises performing liquid phase oxidation of polyalkyl-substituted aromatic aldehyde and/or oxide derivative of polyalkyl-substituted aromatic aldehyde as raw material for oxidation with molecular oxygen at two stages in water solvent in the presence of a catalyst comprising bromine or both bromine and a heavy metal(s) at a temperature of 180 to 280 ° C., thereby producing trimellitic acid or pyromellitic acid, wherein said liquid phase oxidation is performed in a continuous operation at the first stage and in a continuous operation or in a batch operation at the second stage and a total amount of bromine in said catalyst is divided to add separately at each the first stage and the second stage.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: October 1, 2002
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Atsushi Okoshi, Etsuo Urabe, Masashi Yabuno, Hiroshi Ogawa, Kazuo Tanaka
  • Patent number: 6455733
    Abstract: Crude sorbic acid produced in a decomposition step 1 is subjected to a crystallization step 2 to precipitate crystalline sorbic acid, and the crystalline sorbic acid is separated from a mother liquor (filtrate). The mother liquor was subjected to an extraction step 3 in which a specific extractant is employed, and an extract (organic phase) is subjected to a back extraction step 4 and treated with an alkaline solution to extract the sorbic acid into an aqueous phase in the form of a salt. The aqueous phase is neutralized in a neutralization step 6 and the produced sorbic acid is recovered in a separation step 7. As the extractant, use can be made of an organic solvent which is separable from water and has a solubility in water of not more than 1% by weight and in which not less than 0.5% by weight of sorbic acid is dissolvable (e.g., aliphatic C6-20 alcohols, ketones, esters, aromatic ethers).
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: September 24, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Hiroshi Miura
  • Patent number: 6452041
    Abstract: An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. wherein R, R1 and R2 are as defined herein.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 17, 2002
    Assignee: Pfizer Inc.
    Inventors: Andrew Michael Derrick, Nicholas Murray Thomson
  • Patent number: 6441224
    Abstract: Disclosed is a method for selective carboxylation of naphthoic acid, or other aromatic mono-acids to form primarily 2,3-naphthalene dicarboxylic acid (2,3-NDA) or other aromatic diacids which comprises reacting said aromatic mono-acid in the presence of one or more metal oxide catalysts, alone, or in combination, and in the presence of about 0.2 to 0.8 moles excess of base over aromatic mono-acid, at a temperature of about 380° C. to about 420° C., and, in a second step, disproportionating the product of said selective carboxylation at a temperature above about 420° C. to form a product with a greatly improved yield of 2,6-naphthalene dicarboxylic acid, or other aromatic dicarboxylic acid.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: August 27, 2002
    Assignee: Mossi & Ghisolfi Overseas, S. A.
    Inventors: Thomas Fairchild Brownscombe, Donn Anthony DuBois, Susan Secor Pfrehm, William Larry King
  • Patent number: 6441225
    Abstract: A method is provided to produce dicarboxylic or tricarboxylic aromatic acid from salts of such acids, the method including the steps of providing an aqueous solution of a salt of a dicarboxylic or tricarboxylic aromatic acid, the aqueous solution having a pH of about 7 or greater; contacting the aqueous solution with sufficient carbon dioxide to lower the pH of the aqueous solution resulting in precipitation of at least a portion of the dicarboxylic or tricarboxylic aromatic acid; separating precipitated dicarboxylic or tricarboxylic aromatic acid from the solution; and recovering carbon dioxide from the solution.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: August 27, 2002
    Assignee: Mossi & Ghisolfi Overseas, S.A.
    Inventor: Thomas Fairchild Brownscombe
  • Patent number: 6437181
    Abstract: The invention describes a process for the preparation of (S,S)-N,N′-ethylenediaminedisuccinic acid or analogous compounds or their salts by reaction of L-aspartic acid, L-glutamic acid or L-cysteic acid with 1,2-bissulfooxyethane, 1,3,2-dioxathiolane 2,2-dioxide or mixtures thereof or 1,3-bissulfooxy-2-hydroxypropane in the presence of a base, and optional subsequent acidification with an acid. Also described is a process for the preparation of (S,S)-N,N′-ethylenediaminedisuccinic acid or analogous compounds or their salts by reaction of N-(2-sulfooxyethyl)-L-aspartic acid or its salts with L-aspartic acid or corresponding compounds based on L-glutamic acid, L-cysteic acid and/or 1,3-bissulfooxy-2-hydroxypropane in the presence of a base, and optional subsequent acidification with an acid.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: August 20, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Alfred Oftring, Christian Ott, Birgit Potthoff-Karl
  • Patent number: 6437180
    Abstract: A process for preparing aliphatic C4-18 &agr;,&ohgr;-dicarboxylic acids by oxidation of C6-20 &agr;,&ohgr;-dienes with hydrogen peroxide or compounds which release hydrogen peroxide under the reaction conditions as is characterized in that the reaction is carried out in the presence of a transition metal catalyst of group VI and of a mixture containing at least one organic acid and one aprotic organic solvent. A specific temperature profile is maintained at different phases of the reaction, which increases yield and selectivity.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: August 20, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Schelhaas, Helmut Greiving, Manfred Jautelat
  • Patent number: 6437182
    Abstract: The invented process produces sorbic acid by hydrolysis of a polyester in the presence of an acid, which polyester is obtained from ketene and crotonaldehyde. The process includes the step of subjecting a decomposition reaction mixture of the polyester to solid-liquid separation at temperatures ranging from 30° C. to 60° C. to yield sorbic acid as a solid. The process may further include the step of rinsing the sorbic acid obtained by solid-liquid separation with an aqueous solution containing sorbic acid, which aqueous solution is formed in a purification process of sorbic acid subsequent to the solid-liquid separation. The invented process can easily and efficiently remove tar substances by-produced in the reaction and can mitigate loads on a purification process.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: August 20, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Akira Yamashita, Mitsuhiro Kouno
  • Patent number: 6423856
    Abstract: The present invention relates to a process for preparing ester plasticizers from ethylene glycol or the dimers, trimers or tetramers of this compound and linear or branched aliphatic monocarboxylic acids having from 3 to 20 carbon atoms. The reaction is carried out in the presence of organic substances having a boiling point of <112° C., in particular cyclohexane, as azeotrope formers (entrainers) for removing the water of reaction.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: July 23, 2002
    Assignee: Celanese Chemicals Europe GmbH
    Inventors: Helmut Springer, Klaus-Dieter Merscher, Rudolf Heumuller, Klaus Schimmer, Heinz Strutz
  • Patent number: 6420350
    Abstract: Supplement compositions designed to support weight loss and increase energy.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: July 16, 2002
    Assignee: Goen Group, Inc.
    Inventor: Albert M Fleischner
  • Patent number: 6414170
    Abstract: The present invention relates to a method for preparing a cationic surfactant in which physical chemical characteristics such as softness, antistatic properties, etc. as well as biodegradability are quite excellent due to having an ester group and a hydrophilic hydroxyl group in its molecules. A cationic surfactant of the present invention is prepared by reacting tertiary amine drivatives, fatty acid, and epihalohydrin, and prepared simply by reacting esterification and quaternary reactions in one step with a high yield. The above cationic surfactant is a high grade alkyl quaternary ammonium compound as represented in General Formula (1), wherein R1 is a C1-C4 alkyl group; R2 is a C7-C21 linear or branched alkyl or alkenyl group; A is OCOR3, NHCOR3 or OH; R3 is a C7-C21 linear or branched alkyl or alkenyl group; X is a halogen atom; and n is an integral number from 2 to 6.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: July 2, 2002
    Assignee: LG Chemical Ltd.
    Inventors: Dong-Il Kim, Jeong-Wook Ha, Tae-Seong Kim, Moon-Jeong Rang