Abstract: The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises: (a) a discontinuous oil phase; (b) a continuous aqueous phase comprising water; (c) a thickening agent; (d) at least one lamellar membrane structure comprising (i) a phospholipid, (ii) a fatty alcohol, and (iii) a fatty acid; and wherein in use the composition has a water vapor transmission rate of less than about 70 g.m?2.hr?1 measured in vitro using the modWVTR test methodology.
Type:
Grant
Filed:
May 26, 2020
Date of Patent:
May 10, 2022
Assignee:
LG HOUSEHOLD & HEALTH CARE LTD.
Inventors:
Pallav Arvind Bulsara, Martyn J. Clarke, Anthony V. Rawlings
Abstract: New natural-based, eye make-up cosmetic composition, comprising graphene, being free from synthetic polymers, provided with optimal features for ease of distribution and high-definition.
Type:
Grant
Filed:
December 3, 2018
Date of Patent:
March 15, 2022
Assignee:
PRODOTT GIANNI S.R.L
Inventors:
Cecilia Anselmi, Marisanna Centini, Giulia Signori, Maria Francesca Tola
Abstract: The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.
Type:
Grant
Filed:
January 7, 2020
Date of Patent:
March 8, 2022
Assignee:
Ecolab USA Inc.
Inventors:
Junzhong Li, Steven J. Lange, Richard K. Staub, David D. McSherry
Abstract: Disclosed herein is a liquid pharmaceutical formulation substantially free of water, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. Also disclosed herein is a liquid pharmaceutical formulation substantially free of water and ethanol, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin.
Type:
Grant
Filed:
February 24, 2021
Date of Patent:
February 22, 2022
Assignee:
LIQMEDS WORLDWIDE LIMITED
Inventors:
Jayanta Kumar Mandal, Malay Patel, Swati Nagar, Michael Paul DeHart
Abstract: The invention provides for a topical o/w emulsion having moisturizing, and protecting, repairing or restoring the skin lipid barrier of the lips of a mammal, and is a topical oil-in-water emulsion composition comprising: (a) a discontinuous oil phase; (b) a continuous aqueous phase comprising water; (c) a thickening agent; (d) at least one lamellar membrane structure comprising (i) an alkyl amphiphilic component, (ii) an ester of a branched fatty acid and a branched fatty alcohol, (iii) a fatty acid, (iv) a fatty alcohol, and optionally (v) a phospholipid; and wherein in use the composition has a water vapor transmission rate of less than 65 g·m?2·hr?1 measured in vitro.
Type:
Grant
Filed:
June 4, 2020
Date of Patent:
February 22, 2022
Assignee:
LG HOUSEHOLD & HEALTH CARE LTD.
Inventors:
Pallav Arvind Bulsara, Martyn J. Clarke, Anthony V. Rawlings
Abstract: Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.
Abstract: The present invention relates to a novel pharmaceutical composition comprising doxycycline for topical application, in particular to the eye and eyelids. The invention also relates to this topical composition for use in the treatment of bacterial infections of the skin and mucous membranes.
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
January 25, 2022
Assignees:
HORUS PHARMA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Marion Dubald, Sandrine Bourgeois, Hatem Fessi, Martine Claret
Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Type:
Grant
Filed:
November 21, 2018
Date of Patent:
January 25, 2022
Assignee:
Amarin Pharmaceuticals Ireland Limited
Inventors:
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Abstract: A solid temporal colorimetric hydrogel cosmetic composition includes 15 to 99.90 wt % of the water phase part and 0.10 to 85 wt % of the oil phase part, having a refractive index difference of 0 to 0.02 therebetween, and having a color change according to variations in a refractive index difference between the water phase part and the oil phase difference when applied to the skin. The cosmetic composition not only has flexibility through irradiation of gamma-rays, but also enables an optimal application time of the cosmetic composition to be visually confirmed through a color change from transparency to ivory white due to a change in the refractive index difference caused by absorbency and volatilization of water when applying the composition to the skin. The cosmetic composition is capable of improving quality of a product although a preservative irritating to the skin is not added.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
January 4, 2022
Assignee:
COSMECCA KOREA CO., LTD.
Inventors:
Hyun Dae Cho, Jae Yong Seo, Ju Tae Jeong, Soon Ho Choi, Jung Won Shin
Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. Taste-modified compositions also are provided.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
November 30, 2021
Assignee:
ST IP Holding AG
Inventors:
Anthony Chris Garland, Barbara-Jean Anne Bormann-Kennedy, Bomi Framroze, Bret Berner, Michael Edward Grass, Casey Keith Jager, Corey Jay Bloom, Mark Joseph Kastantin, Romain Bachelard
Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a hydrophobic polymer/fatty acid blend. The microparticles of hydrophobic polymer/fatty acid blend selectively absorb preservative allowing the drug to remain in solution for delivery.
Abstract: The present invention relates to an oral soluble film (OSF), methods of orally administering the same, and methods of manufacturing the same. The oral soluble film includes sildenafil citrate, and can further include a binder, filler, flavoring agent, plasticizer, sweetening agent, preservative, solvent, and optionally coloring agent. The active ingredient and excipients can be provided and present in an amount effective to achieve desired physical and performance characteristics of the OSF.
Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Type:
Grant
Filed:
September 3, 2020
Date of Patent:
November 23, 2021
Assignee:
Amarin Pharmaceuticals Ireland Limited
Inventors:
Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
Abstract: Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.
Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
November 9, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Igor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
Abstract: A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
Abstract: The present technology provides methods for preventing or treating dry eyes in a subject in need thereof. The methods include administering to the subject an effective amount of a composition comprising C16:1n7-palmitoleate, its derivatives, pharmaceutically acceptable salts thereof, or a combination thereof.
Abstract: A weight loss composition including banaba leaf extract, apple fruit extract, Rhodiola root extract, zinc chelate, and magnesium chelate are described. The weight loss composition may further include gardenia fruit extract, chromium chelate, Salacia extract, berberine, inositol, or mixtures thereof. Embodiments are also directed to a bulk food product and a weight management plan, which may be used in conjunction with the weight loss composition. Embodiments are also directed to kits and methods of use for treating or preventing obesity, promoting weight loss, and improving insulin resistance.
Type:
Grant
Filed:
May 7, 2020
Date of Patent:
October 12, 2021
Assignee:
GOLO LLC
Inventors:
Christopher Brian Lundin, Terry Shirvani
Abstract: The invention relates to a pharmaceutical composition in the form of an aqueous solution, preferably a syrup, containing inosine pranobex and zinc gluconate, characterised in that it contains a sweetener selected from the group of disaccharides, preferably sucrose or/and from the group of polyols, preferably maltitol, a solubilizer from the group of hydroxy alcohols or mixtures thereof, preferably propylene glycol, glycerol, preservatives selected from the group of parahydroxybenzoic acid esters and mixtures thereof, preferably methyl parahydroxybenzoate, propyl parahydroxybenzoate, a sweetener, preferably sodium saccharine or sucralose, and pH regulators in the range from 5.7 to 12.0 preferably aroma, and a method of preparation thereof.
Type:
Grant
Filed:
June 21, 2018
Date of Patent:
October 5, 2021
Assignee:
AFLOFARM FARMACJA POLSKA SP. Z O. O.
Inventors:
Hanna Wahl, Marek Dąbrowa, Anna Ostrowska, Malgorzata Kowalska - Parteka, Jaroslaw Pasiński, Arkadiusz Madejczyk