Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Abstract: In an example embodiment, a data model, software architecture, and process for synchronizing information about tags is provided, that permits assignment between different microservices. When a tag is added to an entity, then an assignment is made. The assignment is a record that contains a reference to a unique identifier for the tag and also describes the entity's domain and entity type. Each service uses at least one distinct domain, so tag assignments from different services should not conflict with one another.

Abstract: Disclosed herein are non-naturally occurring vesicle comprising a chimeric vesicle localization moiety comprising a surface-and-transmembrane domain of a first vesicle localization moiety and a cytosolic domain of a second vesicle localization moiety, the method of making said vesicle and uses thereof.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Abstract: A design control architecture and software quality assurance system for analyzing stimulus-response patterns in user activity data. A design control architecture and software quality assurance system may process user activity data according to a classifier model to assess an impact of an incremental design change to one or more quality measures of a software product. In accordance with certain embodiments the one or more quality measures may include one or more efficacy, safety, and/or performance metrics associated with one or more features of the software product. In certain embodiments, the software product may comprise a digital health intervention or software as a medical device product.

Abstract: The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.

Abstract: Systems and network devices configured to use Stateless Address Auto-Configuration (SLAAC) to provide different internet protocol (IP) address information to user equipment (UE) devices that are connected to the same local area network (LAN). A network device (e.g., default router, etc.) may determine whether a UE device is eligible to receive special treatment based on a link-layer address of the UE device. The network device send the UE device an unicast router advertisement that includes a special prefix in response to determining that the UE device is eligible to receive special treatment. The network device may send the UE device an unicast router advertisement that includes a base prefix for the LAN in response to determining that the UE device is not eligible to receive special treatment.

Abstract: A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is above a predetermined amount, the subject is treated as a low-risk patient.

Abstract: A protection system for a battery system includes a battery control module configured to selectively open at least one contactor to isolate the battery system from a load in response to a sensed current being greater than a first threshold and within a first current range, at least one fuse connected between first and second terminals of the battery system and configured to open to isolate the battery system from the load in response to the sensed current being greater than a second threshold and within a second current range that is greater than and offset from the first current range, and an auxiliary protection module configured to selectively form a short circuit between first and second terminals in response to the sensed current being greater than the first threshold, less than the second threshold, and within a coverage gap region between the first and second current ranges.

Abstract: A method is provided for resharding a sharded database sharded according to a first shard key. The method includes: receiving, by a processor an instruction to reshard the sharded database; receiving, at the processor, a new shard key to be used in a resharding process to reshard the sharded database; determining, by the processor, whether a duration of unavailability of the sharded database during the resharding process is less than a predetermined amount of time; and automatically performing, by the processor, the resharding process according to the new shard key to produce a resharded database, if the duration of unavailability is less than the predetermined amount of time. The method may be performed without users noticing a significant interruption to read/write operations from/to the database.

Abstract: The invention provides ultraviolet light absorber suitable for use as an additive in polymers, comprising particles of inorganic oxide having UV light-absorbing compound on their surface, wherein said UV light-absorbing compound is chemically bonded, either to a spacer provided on the surface of said particle, or directly to the surface of the particle. Process for preparing the additive absorber and a thermoplastic polymer (e.g., a film) comprising the absorber additive are also provided.

Abstract: A processor-implemented method includes obtaining measurement data indicative of a physiological condition measured by a sensing arrangement located at a site on a body, determining a lag associated with the sensing arrangement based on a relationship between the measurement data and reference data, and identifying, based on the lag, the site at which the sensing arrangement is located from a plurality of sites on the body.

Abstract: Aspects relate to systems and methods of use for a crash safe battery pack that includes a case, a first battery module located within the case and mounted to the case with at least a breakaway mount, a second battery module located within the case, a frangible connection configured to provide electrical conduction between the first battery module and the second battery module, and a die configured to contact and separate the frangible connection when the crash safe battery pack is impacted with a sufficiently great connection breaking force.

Abstract: Methods and systems for providing multiple techniques to a customer premises equipment to acquire network connectivity. A method for acquiring an Internet Protocol (IP) lease includes sending, by a network device at a customer premises to a service provider system, a request for a preferred acquisition posture, where the network device is provisioned with multiple acquisition postures including the preferred acquisition posture, receiving, by the network device from the service provider system, a selected acquisition posture, attempting, by the network device, to acquire the IP lease using the selected acquisition posture, and operating, by the network device, using the acquired IP lease.

Abstract: A medical device includes a base having a first surface to be secured to a patient's skin. A first insertable member has a length portion extending from the first surface of the base for insertion. A second insertable member has a length portion extending from the first surface of the base for insertion through the patient's skin. The first insertable member includes a sensor member for sensing a biological condition, and the second insertable member includes an infusion cannula for infusing an infusion media. The distal end of the first insertable member and the distal end of the second insertable member are spaced apart by a first distance of at least 5.0 mm, for reducing interference of the infusion media from the infusion cannula with an operation of the sensor member.

Abstract: A power control system for a battery system of a vehicle includes a first contactor, a second contactor, N fuses and N vehicle loads. An active sacrificial protection device includes a third contactor and a first fuse. The active sacrificial protection device is connected to a positive or negative terminal of the battery system. A current sensor is configured to sense a measured load current flowing through one of the first contactor and the second contactor. A battery management module is configured to selectively close the third contactor to reduce current flowing through one of the first contactor or the second contactor and selectively open the one of the first contactor or the second contactor after closing the third contactor.

Abstract: A database system comprising a database comprising a plurality of data storage nodes, the plurality of data storage nodes including a primary storage node and a plurality of secondary storage nodes. The database system may also include at least one processor configured to: perform at least one write command to a secondary storage node of the plurality of secondary storage nodes; and perform at least one backup command, at least partially in parallel with the at least one write command being performed to the secondary storage node, of at least some data from a snapshot of data stored in the secondary storage node. A method for performing at least one backup command in a database at least partially in parallel with the at least one write command being performed.

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, the system may include a device (e.g., an implantable pulse generator) and an electrode device electrically coupled to the device. In some examples, the device may be configured to generate a current that is to be applied to the anatomical element via the electrode device to stimulate the anatomical element as part of a therapy aimed at achieving or supporting glycemic control in the patient. Additionally, the current may be applied to the anatomical element based on a machine learning algorithm that uses inputs gathered for determining one or more characteristics for the current. Accordingly, the machine learning algorithm may be configured to determine the one or more characteristics for the current specific to the patient (e.g., to provide personalized therapy settings for the patient).

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, a device may be configured to generate a current, and an electrode device coupled to the device may be configured to apply the current to the anatomical element. Additionally, the system may include a user interface in communication with the implantable pulse generator, the electrode device, or both. In some examples, the user interface may include a first element that is configured to display information associated with the patient. Additionally, the user interface may include a second element that is configured to receive inputs for programming parameters of the current. The user interface may also include a third element that is configured to display diagnostic information associated with applying the current to the anatomical element.