Abstract: The present disclosure describes use of oxytocin, in combination with one or more other agents as described herein, for use for example in the treatment of certain conditions.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting the use of remote procedure calls in microservices environments. A microservices (e.g., Helidon) environment provides a development framework that enables a software developer to create and use microservices. A remote procedure call (RPC) framework or component, such as, for example, a gRPC framework, enables client and server applications to communicate within the microservices environment, to build connected systems. In accordance with an embodiment, the gRPC framework enables communication between client and server applications associated with an in-memory data grid environment, such as, for example, an Oracle Coherence environment.

Abstract: An apparatus is provided for subcutaneous implantation in a patient using a tunneling instrument. The implantation apparatus comprises a vascular graft and a connector adapted to couple a distal end of the tunneling instrument and a proximal end of the graft. The connector comprises a tip, a first end of the tip configured to be received within the proximal end of the graft, a clip for securing the graft to the tip, and a coupler for a rotatable connection of the tip to the tunneling instrument such that the tip is rotatable about its longitudinal axis relative to the coupler to facilitate attachment of the graft to the tunneling instrument. The implantation apparatus may further comprise a removable sheath configured to substantially cover the length of the graft.

Abstract: Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. The canonical cancer-testis antigen, NY-ESO-1, is not expressed in normal tissues but is aberrantly expressed across a broad array of cancer types. It has also been targeted with A2-restricted TCR gene therapy without adverse events or notable side effects. To enable the targeting of NY-ESO-1 in a broader array of HLA haplotypes, we isolated TCRs specific for NY-ESO-1 epitopes presented by four MHC molecules: HLA-A2, -B07, -B18, and -C03. Using these TCRs, we have developed an approach to extend TCR gene therapies targeting NY-ESO-1 to patient populations beyond those expressing HLA-A2.

Abstract: Embodiments of the disclosure provide a method and system for processing a customer inquiry. The method includes obtaining multiple conversations. Each of the conversations includes multiple conversation entries associated with the conversation. The method also includes, for each of the conversations, generating a directed path from a start to an end of the historical conversation. The directed path includes multiple edges and vertices. Each of the edges represents a conversation entry or an API call associated with the conversation, and each of the vertices represents a state of the conversation. The method further includes generating a directed graph based on the generated directed paths and determining an optimized directed path based on the directed graph. The method also includes receiving a customer inquiry from a user device associated with a customer, and generating a response based on the optimized directed path.

Abstract: A method of covering a portion of a fastener, protruding from a surface, that comprises providing a cap comprising a wall, a base, an interior, at least partially delimited by the wall and the base, and pawls, located in the interior of the cap. The method further comprises coupling a tooth to the fastener, covering the portion of the fastener with the cap, and positively engaging the pawls with the tooth, such that the pawls are loaded in tension against the tooth.

Abstract: Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof: wherein Q1, Q2, Q3, R2a, R2b, R3 and X are as defined herein.

Abstract: A pneumatic fastener driver operable in a single sequential mode and a bump-fire mode, and includes a housing, a nosepiece, a trigger moveable between a default position and a depressed position, a contact arm movable relative to the nosepiece between an extended position and a retracted position, and a timeout mechanism operable in the bump-fire mode to inhibit the drive cycle from being initiated in response to inactivity of the contact arm over a preset time interval defined by unwinding of a mainspring that is initially wound in response to the trigger being actuated from the default position to the depressed position. The pneumatic fastener driver also includes a counting assembly having a female barrel pivotably coupled to a pivot shaft of the trigger and driven by the mainspring and a lockout linkage coupled to the female barrel that is capable of interfering with a portion of the trigger.

Abstract: A genetically-modified bacterium, for example of the class Actinobacteria, and the use of such a bacterium in the bioconversion of a steroidal substrate into a steroidal product of interest. A method of converting a steroidal substrate into a steroidal product of interest, wherein the method comprises: inoculating culture medium with genetically-modified bacteria according to any of Claims 1 to 28 and growing the bacterial culture until a target OD600 is reached; adding a steroidal substrate to the bacterial culture when the target OD600 is reached; culturing the bacterial culture so that the steroidal substrate is converted to the steroidal product of interest; and extracting and/or purifying the steroidal product of interest from the bacterial culture.

Abstract: A mule shoe or UBHO sub with internal flow control is provided. The device has a fluid flow controlling interior surface feature which produces a predictable fluid flow. Specifically, the device, which is an elongated hollow cylinder, has internal “rifling” to produce a swirling flow pattern within the device. This flow pattern reduces turbulence within the sub, and prevents washing out of the pin during heavy fluid flow.

Abstract: A filter element includes first filter media, second filter media, a frame, and a seal member. The frame is coupled to the first filter media and the second filter media, the frame securing the first filter media and the second filter media into a V-shape. The seal member is attached to and extends from the frame. The seal member includes a U-shaped channel structured to receive a ridge of a housing when the filter element is installed in the housing. The seal member is structured to form a seal between the filter element and the housing when the filter element is installed in the housing.

Abstract: A fully digital integrated circuit apparatus (200) and method (300) are provided for generating a test mode enable signal with a digital non-resettable state retention storage circuit (210) connected to store an authentication control pattern for authorizing test mode access to a secure circuit, a digital safety interlock gate circuit (220) connected to store a safety interlock gate setting that may be accessed independently from a test mode enable signal, and combinatorial logic circuitry (205) for generating the test mode enable signal only when the interlock safety gate setting is set to a first value and the digital non-resettable state retention storage circuit stores the authentication control code.

Abstract: A refiner plate segment including a plurality of bars and grooves for refining lignocellulosic materials, where the grooves between adjacent bars includes a plurality of teeth having a wave-like profile with alternating high and low points. The wave-like profile of the teeth within the grooves increases turbulence in the refining process to tumble the fibers and push them toward the refining gap to reduce energy and improve the efficiency of the fiber reduction process.

Abstract: A code scanning system has a syntax generation component that receives source code and generates an abstract syntax tree file. The system includes a white list of permitted pure functions, and a black list of prohibited impure functions. In addition, the system includes a static code analyzer for performing static analysis of the source code. The static code analyzer includes a function analyzer that receives the AST file and identifies the functions. Each function is compared to the white list, and if it is present, marked as permitted in a static analysis file. If the function is not on the white list, it is compared to the black list. If it is present on the black list, it is marked as prohibited in the static analysis file. If the function is not on the white or black list, it is marked as “unknown” and subjected to manual analysis.

Abstract: A clamp device to clamp to a fishing pole and strip fishing line may include a first clamp member, a second clamp member to pivotably connect to the first clamp member, and a spool member to connect to the first clamp member and the second clamp member to the fishing rod and to rotate and to strip fishing line. The first clamp member may include a first clamp pivoting device. The second clamp member may include a second clamp pivoting device. The first clamp member may include a first clamp arm. The second clamp member may include a second clamp arm. The first clamp arm may include a first clamp slot.

Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

Abstract: A roofing system for a Jeep type multiple row seating Jeep type SUV having a parallel separated longitudinal support beam structure extending roll cage with rear ends of the longitudinal support beams inclined to a belt line of the vehicle, the system including a rear rigid portion extending transverse of the vehicle, a cloth portion forward of the rigid portion covering at least a front seating row of the vehicle being openable.

Abstract: Force modulating tissue bridges, and associated applicators, kits and methods are provided. A force modulating tissue bridge can be a medical article for at least partially covering a wound and/or scar tissue. The medical article can include an elastic arch extending over an area, and a medial strut connected to the arch and extending into the area over which the central section extends.

Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.