Abstract: The present disclosure relates to Dsg2 binding molecules, nucleic acid molecules encoding the Dsg2 binding molecules and compositions comprising the same and methods of use thereof for treating or preventing cancer.

Abstract: This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.

Abstract: A surgical stapling system includes a motor, a gear reducer assembly, a drive train, and a motor controller. A method of controlling the motor includes applying a first signal to the motor, receiving drive train operational data, comparing the drive train data to baseline data, and applying a signal having a different shape than the first signal to the motor. A method of characterizing the motor includes transmitting a perturbation signal, receiving motor function parameters, determining stapler system characteristics, and adjusting a controller function. A method of controlling a stepper motor includes applying a signal to the stepper motor, receiving stepper motor operational data, comparing the data to baseline data, and adjusting the signal. Another method of controlling the motor includes receiving motor rotational data, receiving gear rotation data, calculating a mechanical transfer function, determining non-idealities of the stapling system, and modifying a control signal based on the non-idealities.

Abstract: Disclosed is a surgical instrument for treating tissue in a surgical procedure. The surgical instrument comprises an end effector, comprising an anvil, and a staple cartridge. The surgical instrument further comprises a drive train operably coupled to the end effector, a motor configured to motivate the drive train based on a default control algorithm to affect a tissue treatment motion of the end effector, and a sensor configured to monitor an independent parameter of the surgical procedure. The independent parameter is independent of the motion of the end effector. The surgical instrument further comprises a control circuit coupled to the motor and the sensor. The control circuit is configured to receive an input from the sensor indicative of the independent parameter, and adjust the default control algorithm based on the independent parameter.

Abstract: A surgical instrument is disclosed including an end effector, a firing member movable from an unfired position toward a fired position during a firing stroke, a firing system comprising a motor, and a control system. The end effector comprises a first jaw, a second jaw moveable relative to the first jaw, and a staple cartridge. The firing system is configured to drive the firing member through the firing stroke. The control system is configured to drive the firing member from the unfired position toward the fired position with the firing system, detect a force to fire the firing member toward the fired position, predict a future force to fire the firing member, based on the detected force to fire, and dynamically adjust a firing algorithm of the firing system, based on the prediction.

Abstract: Examples of the present disclosure describe systems and methods for detecting and remediating compression artifacts in multimedia items. In example aspects, a machine learning model is trained on a dataset related to compression artifacts and non-compression artifacts. Input data may then be collected by a data collection module and provided to a pattern recognition module. The pattern recognition module may extract visual and audio features of the multimedia item and provide the extracted features to the trained machine learning model. The trained machine learning model may compare the extracted features to the model, and a confidence value may be generated. The confidence value may be compared to a confidence value threshold. If the confidence value is equal to or exceeds the confidence threshold, then the input data may be classified as containing at least one compression artifact. Remedial action may subsequently be applied (e.g., boosting the system with technical resources).

Abstract: A snow and ice vehicle accumulation determination and removal system for an electrified vehicle uses weight/load estimation methods based on vehicle sensors and user input to determine if the vehicle has accumulated a significant amount of snow/ice that could negatively affect the vehicle range. When a weight variation exists above a predetermined threshold which can be accounted for only as being due to snow and ice, then the invention may (1) warn the driver of reduced range and the reason for it, (2) perform drivetrain and/or cabin heating that may contribute to melting of the snow and ice (e.g., automatically adjusting powertrain performance to generate increase heat, such as running at a higher RPM), and/or (3) instruct the driver to proceed to an environment which can warm the vehicle (such as a facility equipped with a hot water spraying device).

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4A, R4b, and R5, are as defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL.

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.

Abstract: A patient interface system for delivery of respiratory therapy to a patient comprises: a nasal portion including a nasal chamber and a nasal sealing portion adapted to form a seal with the patients including an opening; an inlet conduit connected to the nasal portion to deliver the pressurized, breathable gas to the nasal chamber; and a nasal chamber coupling component adapted to form part of a releasable fluid coupling to enable the nasal portion to be fluidly coupled to a mouth portion to communicate a portion of the pressurized, breathable gas through the nasal chamber opening to the mouth portion.

Abstract: A hydrocarbon control system includes a base device, a field device, and a mobile device. The base device includes a key generator configured to generate a temporary key. The field device is configured to restrict or allow access based on verification of a received key. The mobile device is configured to communicate with the base device to receive the temporary key when in proximity of the base device, communicate with the field device to provide the temporary key to the field device when in proximity of the field device, and exchange data with the field device in response to the field device verifying the temporary key.

Abstract: A surgical system is disclosed including a surgical instrument and a control system. The surgical instrument comprises an end effector, a first drive system, and a second drive system. The control system is configured to detect the actuation of the first drive system of the surgical instrument, drive a first function of the end effector using the first drive system, monitor a first parameter associated with a first function, set a second parameter associated with a second function of the end effector based on the monitored first parameter, and drive the second function of the end effector using the second drive system.

Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

Abstract: The invention relates to improvements in drug delivery and more particularly to the use of Cell Penetrating Agents (CPA's) or Cell Penetrating Peptides (CPP's) which have been stabilized by, for example: i) stapling two amino acids to form Stapled CPP's (StaP's) or ii) stitching three or more amino acids to form stitched CPP's (StiP's). These stabilized CPP's are conjugated to a drug or Biologically Active Compound (BAC) directly or via a Bi-Functional Linker (BFL) so that the BAC can be carried though a cell membrane by the CPP. The resulting molecules are referred to as Drug Carrying Cell Penetrating Molecules (DCCPM's). The preferred BAC is an electrically low charge carrying oligonucleotide such as a phosphorodiamidate morpholino oligonucleotide (PMO).

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: An apparatus includes an end effector, a motor, and a processing unit. The processing unit is configured to activate the motor to distally advance a firing member within a body of the end effector. The processing unit is further configured to detect an initiation condition. In response to detecting the initiation condition, the processing unit is configured to activate an algorithmic bumping mode. The bumping mode includes activating the motor to advance the firing member distally with a first plurality starting and stopping motions at a first rate and a first power level. The bumping mode further includes activating the motor to retract the firing member proximally with a second plurality of starting and stopping motions at a second rate and a second power level. The first rate is different than the second rate. The first power level is different than the second power level.

Abstract: A surgical instrument including a system for stopping a beam of the surgical instrument from impacting a distal pin when reversing a knife is disclosed. A knife assembly of the surgical instrument comprises the knife, the beam, and a firing nut. A firing lead screw can drive the firing nut distally and proximally. A firing screw compression spring extends along the firing lead screw and applies a load proximally on the firing nut when the firing nut is driven toward a distal end of the firing lead screw.

Abstract: Systems, computer program products, and methods are described herein for the parallel testing of multiple data processing channels. The present invention may be configured to generate a data packet, send the data packet to a processing channel for processing at a send time, receive the processed data from the processing channel at a return time, determine the percent accuracy for the processed data from the processing channel, and record the send time, return time, and percent accuracy in an analytics system. The present invention may also be configured to determine the security of the processing channel and record the security in the analytics system.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.