Abstract: Provided herein, in some embodiments, are fusion proteins comprising recombinantly engineered variant of stefin polypeptide (an AFFIMER® polypeptide) that binds to PD-L1 and a polypeptide that binds to human serum albumin (HSA). Also provided herein, in some embodiments, are compositions containing the fusion proteins, methods of using the fusion proteins, and methods of producing the fusion proteins.

Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseases a sole agent or in combination with other active ingredients.

Abstract: Systems, devices, methods, and non-transitory computer-readable instructions for detecting deception of a subject from a media stream that capture a media stream of the subject including, the media stream including a sequence of frames, process each frame of the media stream to track a plurality of biometrics, and determine whether the subject in the media stream is deceptive based upon changes to respective biometrics.

Abstract: Disclosed is a method for determining an atmospheric radiative forcing difference by optimising or preventing contrail formation caused by an aircraft. The method comprises receiving one or more weather parameters to determine contrail forecast data; receiving one or more flight parameters associated with aircraft to determine flight data; determining tentative atmospheric radiative forcing quantity, along tentative flight trajectory, based on contrail forecast data and flight data; altering one or more flight parameters to determine optimised flight trajectory having optimum atmospheric radiative forcing quantity, wherein optimised flight trajectory is validated using imagery data; and determining an atmospheric radiative forcing difference to evaluate offset value for at least one forcing parameter associated with atmospheric radiative forcing difference. Disclosed also is an apparatus for determining atmospheric radiative forcing caused by aircraft by optimising or preventing contrail formation.

Abstract: The present invention relates to compounds that act as DUX4 repressors, suitable for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: A series of substituted 4,4-difluorocyclohexyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: Systems, computer-implemented methods, apparatus and/or computer program products are provided that facilitate improving the accuracy of global positioning system (GPS) coordinates of indoor photos. The disclosed subject matter further provides systems, computer-implemented methods, apparatus and/or computer program products that facilitate generating exterior photos of structures based on GPS coordinates of indoor photos.

Abstract: A method of operating a door system includes sensing a user on an exterior side of a door panel in physical propinquity to the lock such that the lock transitions from a sleep state to an active state, authenticating the user when the lock is in the active state before converting the lock from a locked configuration to an unlocked configuration, and converting the lock from the locked configuration to the unlocked configuration in response to transition to the active state. Authenticating the user includes receiving an authentication signal from a remote device on the user in physical propinquity to the to the lock.

Abstract: Provided are methods and systems related to communications between a social media service or provider (e.g., Twitter®, Facebook®) or other resource (e.g., web page) and one or more content providers. In an aspect, provided are methods comprising receiving a request for content, wherein the request comprises a user agnostic identifier, determining user information associated with the request, determining time information associated with the request, determining media content associated with the user agnostic identifier based on the time information, determining one or more access rights to the media content based on the user information, and providing access to the media content based on the one or more access rights.

Abstract: A zone mobility system and method for an autonomous device includes a work area within which the autonomous device is intended to operate, one or more electrically separated boundary conductors, each boundary conductor surrounding a work zone within the work area, a transmitter base electrically connected to at least one of the boundary conductors, and a removably coupled transmitter configured to transmit a signal for directing movement of the autonomous device on the boundary conductor wire. The transmitted signal can be adjusted to optimize the power consumption of the transmitter, and a work operation can be commenced utilizing a transmitter interface, and/or utilizing an autonomous device user interface.

Abstract: In one embodiment, an apparatus includes at least one vertical transistor, where the at least one vertical transistor includes: a substrate comprising a semiconductor material, an array of three dimensional (3D) structures above the substrate, a gate region, and an isolation region positioned between the 3D structures. Each 3D structure includes the semiconductor material. Each 3D structure also includes a first region having a first conductivity type and a second region having a second conductivity type, the second region including a portion of at least one vertical sidewall of the 3D structure. The gate region is present on a portion of an upper surface of the second region and the gate region is coupled to a portion of the at least one vertical sidewall of each 3D structure.

Abstract: A retarding control assembly for a brake valve may include a bleed line configured for arrangement between a spring chamber of a brake command assembly and a tank line. The bleed line may include a check valve configured to allow fluid flow from the spring chamber to the tank and a check valve bypass configured to allow fluid flow from the tank line to the spring chamber passed the check valve and defining a restricted pathway.

Abstract: In one inventive concept, a method for etching an optic includes obtaining a microemulsion, where the microemulsion includes a continuous oil phase, a surfactant system comprising at least one surfactant, and water, submerging at least a portion of the optic in the microemulsion, and agitating by ultrasonication the microemulsion for etching the optic submerged therein.

Abstract: A ventilation device includes a mechanical ventilator (10), respiratory sensors (30, 32) configured to acquire measurements of respiratory variables including at least measurements of airway pressure and airway flow, and an electronic processor (14) programmed to perform a ventilation method including: operating the mechanical ventilator to provide mechanical ventilation controlled using measurements acquired by the respiratory sensors; performing a pause maneuver comprising closing at least one of an inhalation valve (38) and an exhalation valve (40) for a pause interval and estimating a respiratory mechanics index from one or more respiratory system parameters estimated from measurements acquired by the respiratory sensors during or after the pause interval; and triggering a pause maneuver in response to detecting a change in the estimated respiratory mechanics index.

Abstract: Techniques and apparatuses directed to improved pawl-latching devices are described in this document. The disclosed techniques and apparatuses provide pawl-latching devices with pawls structured to avoid the sinking and warping problems present in some conventional injection molding processes. In aspects, the pawl-latching devices include a pawl having at least one of a pivot member including a notch, a release feature on the pawl spaced apart from the front and sides of the pawl, a recess defined in the top of the pawl, and/or a recess defined in the bottom of the pawl.

Abstract: The principles of the present invention further provide both a shaped metal container and its preforms that exhibit a rounded grain structure characteristic created by an annealing process and a method for making a shaped metal container. The process of making said metal container results in a quicker process time and uses less metals (at least 10% metal weight savings), thus allowing for a decrease in the costs of making such shaped metal containers. A shaped metal container may include work hardened rolled sheet-metal defining a sidewall, an opening, and a base, where at least one section along the sidewall has grains with an average aspect ratio less than about 4 to 1.

Abstract: A manual release assembly for a surgical tool includes a first release plate including a first pair of arms engageable with a first pair release gears arranged within a drive housing, a second release plate including a second pair of arms engageable with a second pair release gears arranged within the dive housing, and a first angled slot defined in the first release plate and a second angled slot defined in the second release plate. A release switch provides a transition pin extendable into the angled slots and manually movable between disengaged and engaged positions. When in the disengaged position, the arms are disengaged from the release gears, and when manually moved to the engaged position, the transition pin moves through the angled slots and urges the release plates in opposing lateral directions such that the arms engage and rotate the release gears.

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient. The drug delivery system may further include one or more sensors coupled to the drug delivery device, a wireless transmitter, and a controller coupled to the one or more sensors and the wireless transmitter. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device, and control the wireless transmitter to wirelessly transmit one or more reports representative of the condition or the operational state of the drug delivery device. A method for use with a drug delivery device is also disclosed.

Abstract: Provided herein are method, apparatus, and computer program products for automatically outputting a wearer interface or a redemption interface. The wearer interface and the redemption interface may contain information related to a wearer of a wearable device and a provider respectively. The wearable device may reference a merchant redemption parameters database to facilitate the output of the redemption interface, and the wearable device my reference a wearer parameters database to facilitate the output of the wearer interface. Both the wearer interface and the redemption interface may be displayed on the wearable device by an interactive display.

Abstract: In accordance with a method and system for facilitating redemption of monetary value gaming tickets, such as issued by a gaming device upon cash-out, a ticket is presented, such as to a redemption kiosk. If the ticket is validated and has a monetary value which includes a fractional currency value, then the player is presented a wagering game based upon a wager comprising at least the fractional currency value of the ticket or is provided entries into a game or promotional event, wherein winnings may be paid in a whole value as part of the ticket redemption or as separate prizes, whereby dispensing of fractional value, such as coins, may be avoided.