Abstract: Techniques for identifying mention identifiers within a message using a mentions processor are discussed herein. In some examples, a communication platform maintains a mentions processor configured to receive a message including a mention identifier, analyze the message to determine a type of the mention identifier included in the message, identify a second user account or a virtual space referenced by the mention identifier, determine whether a notification should be sent to the second user account or the virtual space, and, upon determining that the notification should be sent, send the notification associated with the message to the second user profile or the virtual space. In some examples, an observability class associated with the mentions processor allows the use of a mentions lookup tool to view one or more stored mention identifiers associated with the message and one or more stored notifications enqueued for the message.

Abstract: Provided herein are proteins comprising one monovalent human TfR binding domain (“human TfR binding proteins”), proteins comprising one monovalent mouse TfR binding domain (“mouse TfR binding proteins”), conjugates comprising such human or mouse TfR binding proteins, e.g., human TfR binding proteins-dsRNA conjugates, pharmaceutical compositions comprising human TfR binding proteins or conjugates, and methods of treating CNS diseases (e.g., neurodegenerative disease such as neurodegenerative synucleinopathy or tauopathy) using human TfR binding proteins or conjugates.

Abstract: The present disclosure provides methods of processing or analyzing a sample. A method for processing a sample may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule), barcoding the probe-nucleic acid molecule complex, and performing extension, denaturation, and amplification processes. A method for processing a sample may comprise hybridizing first and second probes to adjacent or non-adjacent target regions of a nucleic acid molecule (e.g., an RNA molecule), linking the first and second probes to provide a probe-linked nucleic acid molecule, and barcoding the probe-linked nucleic acid molecule. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well. One or more processes of the methods described herein may be performed on a cell, such as a permeabilized cell.

Abstract: A system and method for moving a magnetic piece across a board comprising a plurality of electromagnets. The plurality of electromagnets comprises an origin electromagnet and a destination electromagnet. First, a magnetic field is generated at the destination electromagnet such that the magnetic piece would be repulsed by the center of the destination electromagnet. Next, a magnetic field is generated at the origin electromagnet such that the magnetic piece is repulsed by the center of the origin electromagnet such that the piece moves to the edge of the origin and destination magnet. Then, a magnetic field is generated at the destination electromagnet that attracts the magnetic piece to the center of the destination electromagnet such that the piece moves to the center of the destination electromagnet.

Abstract: An incisionless fully endoscopic method of reducing the capacity of the stomach is provided to surgically treat obesity. The method is directed to endoluminal tissue approximation of a portion of the stomach, including at least a portion of the greater curvature thereof. The method includes a pattern of stitching in which a portion of the stomach is closed off. One stitching pattern causes the lateral portion of the stomach to be drawn to reduce the usable volume of the stomach while maintaining a pathway from the esophagus to the pylorus. As the stitching pattern advances, the fundus is automatically drawn downward so that it may be endoscopically approached for stitching in a facilitated manner According to another aspect of the invention, another stitching pattern extends from the antrum to the fundus between the anterior and posterior portions of the stomach.

Abstract: Proanthocyanidin-cinnamaldehydes pyrylium products (FP) were synthesized by the condensation reaction of proantho-cyanidins (PAC) with various cinnamaldehydes. Synthesized FP exhibited fluorescence at higher excitation and emission wavelengths than PAC. FP were evaluated for their ability to agglutinate extra-intestinal pathogenic Escherichia coli (ExPEC). Results showed that FP were significantly more bioactive (p-value<0.05) for agglutinating ExPEC compared to PAC. Scanning electron microscopy indicates that FP interacts with ExPEC surface structures and suggests that FP have higher affinity with the fimbriae-like structures on the surface of ExPEC in comparison to PAC. In addition, fluorescent microscopy performed on in vitro and in vivo agglutination assays show that FP entrap ExPEC in a web-like network, thus demonstrating agglutination of ExPEC. Fluorescent proanthocyanidins offer a new approach to visualize bacterial infections and to treat such infections.

Abstract: A self-drilling bone fusion screw apparatus is disclosed which includes at least first and second sliding boxes. A first screw member having a tapered end and a threaded body is disposed within the first sliding box, and a second screw member having a tapered end and a threaded body disposed within the second sliding box. An adjuster adjusts the height of the sliding boxes. The screw members are screwed into vertebral bodies in order to fuse the vertebral bodies together. A plurality of the self-drilling bone fusion screw apparatuses may be attached together and/or integrated via a plate or cage. Also disclosed is a cervical facet staple that includes a curved staple base and at least two prongs attached to the bottom surface of the curved staple base.

Abstract: A rack assembly for use with an automatic retail device. The rack assembly includes a rack body comprising and a load bar configured to mount to the rack body. The rack body includes a fastening element configured to mount the rack body to a portion of the automatic retail device and a main shelf controller disposed within the rack body and in communication with a microcontroller of the automatic retail device. The load bar includes a weight sensor configured to sense a weight of products positioned on the load bar and a circuit board. The circuit board is disposed on the load bar and in electrical communication with the weight sensor and the main shelf controller. The circuit board transmits a signal corresponding to the weight sensed by the weight sensor to the microcontroller via the main shelf controller.

Abstract: The present disclosure relates to methods and systems of determining swimming metrics of a user during a swimming session. The method can include receiving, by a processor circuit of a user device, motion information from one or more motion sensors of the user device; determining, by the processor circuit using the motion information, a first set of rotational data of the user device, wherein the first set of rotational data is expressed in a first frame of reference; converting, by the processor circuit, the first set of rotational data into a second set of rotational data, wherein the second set of rotational data is expressed in a second frame of reference; determining, by the processor circuit, one or more swimming metrics of the user; and outputting the one or more swimming metrics.

Abstract: Provided herein are methods of determining a location of a target nucleic acid in a biological sample.

Abstract: An example method for vane classification includes scanning, using a structured light scanner, a vane for a turbine engine to capture three-dimensional (3D) data about the vane. The method further includes generating a point cloud from the 3D data about the vane. The method further includes connecting, using a processing system, points of the point cloud to generate a mesh surface. The method further includes determining, using the processing system, an airflow for an airfoil of the vane based at least in part on the mesh surface. The method further includes constructing the turbine engine based at least in part on the airflow for the airfoil of the vane without reference to an adjacent airfoil of the vane.

Abstract: Systems provide a chassis that support interchangeable hardware accelerator baseboards. The geometry of a first accelerator baseboard tray corresponds to the geometry of a first accelerator baseboard. The geometry of a second accelerator baseboard tray corresponds to the geometry of a second accelerator baseboard. A chassis incudes an accelerator baseboard compartment that includes a plurality of structures mounted on its base, where these structures receive corresponding structures of the first tray and that also receive corresponding structures of the second tray. Installation of the first tray on the structures mounted on the base of the compartment and installation of the first accelerator baseboard on the first tray aligns the first accelerator baseboard within the compartment. Installation of the second tray on the structures mounted on the base of the compartment and installation of the second accelerator baseboard on the second tray aligns the second accelerator baseboard within the compartment.

Abstract: Embodiments of the systems and methods disclosed herein provide a gaming console and gaming controllers, including hardware and software features included on the hardware. For example, a game balancing system is described that can monitor and track performance data from one or more players of the gaming console. With the performance data, artificial intelligence and machine learning can be used to create one or more models that are applied to determine adjustments to games being played on the gaming console. The adjustments to the games can be implemented specifically to each game, player, or set of players to achieve more balanced gameplay as measured by game outcomes and other factors.

Abstract: An information technology equipment enclosure comprises a plurality of IT components, cold plates disposed over at least two of the IT components, and a cooling fluid manifold disposed within the IT equipment enclosure. The coolant liquid manifold has multiple input connectors and multiple output connectors. Each of the cold plates are coupled to the cooling fluid manifold using a coolant line attached to one of the input connectors and a coolant line attached to one of the output connectors. An input cooling liquid line couples the coolant liquid manifold to an output of an external liquid cooling system, and an output liquid line couples the coolant liquid manifold to an input of the external liquid cooling system. The coolant liquid manifold is configured to receive cooling fluid from the external liquid cooling system and to distribute the cooling fluid to all of the cold plates via the input connectors.

Abstract: In one embodiment, an information technology (IT) equipment enclosure comprises a first portion of a chassis configured with one or more compute devices fixedly mounted to the chassis and a second portion of the chassis configured to receive a removable storage tray module, the storage tray module configured with one or more storage devices and one or more cooling devices. The removable storage tray module comprising a handle that is pivotable between a locked position and an unlocked position. The handle comprises a recessed portion that is configured to route cables to the storage devices when the handle is in the locked position. The handle may engage a sidewall of the chassis when in the locked position. The cooling devices are selected based upon the one or more storage devices on the storage tray module. The cooling devices may be fans.

Abstract: An information technology equipment enclosure comprises a plurality of IT components with cold plates coupled to the IT components. A cooling fluid manifold is disposed within the IT equipment enclosure, wherein each of the cold plates are coupled to the cooling fluid manifold via an input coolant line and an output coolant line. A liquid line routing assembly is disposed within the enclosure. The liquid line routing assembly comprises at least one sidewall and one or more openings in the at least one sidewall. The openings are configured to provide a path to route input coolant lines and output coolant lines to selected ones of the cold plates. The at least one sidewall includes a gate structure positioned over at least one of the openings. The gate structure is configured to pivot away from the at least one opening to provide access to the opening.

Abstract: A rotor bearing system configured to operatively couple a progressing cavity machine to an external device can comprise a housing including an inner surface defining a first bore extending through the housing along a central axis, a first bearing arranged on the inner surface, and a shaft member including an outer surface extending between a proximal portion and a distal portion of the shaft member and a second bearing arranged on the outer surface, the second bearing the second bearing configured to contact the first bearing to limit eccentric motion of the driveshaft of the external device and the rotor head of the progressing cavity machine relative to a stator of the progressing cavity machine during rotation of the rotor head, the shaft member, and the driveshaft.