Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.

Abstract: This disclosure generally relates to one or more safety mechanisms of a rechargeable battery for light electric vehicles. The rechargeable battery may include a housing containing a battery management system and at least one battery cell, and a communication system communicatively coupled to the battery management system, where the communication system wirelessly communicates information received from the battery management system to a device external to the rechargeable battery. The rechargeable battery may include a housing formed of a first clamshell member and a second clamshell member. The rechargeable battery may include a first protrusion portion extending from an interior surface of the first clamshell member and a second protrusion portion extending from the interior surface of the second clamshell member toward the first protrusion portion such that the first and second protrusion portions physically contact one another when a force is applied to an external surface of the housing.

Abstract: An apparatus for performing a medical procedure and, in particular, an aortic valvuloplasty, in a vessel for transmitting a flow of fluid. The apparatus includes an inflatable perfusion balloon including an internal passage for permitting the fluid flow in the vessel while the perfusion balloon is in an inflated condition, the balloon including a plurality of cells in a single cross section and a covering for at least partially covering the cells. A valve associated with the balloon controls the fluid flow within the passage, the valve being arranged external to the passage. The valve may form a tubular extension of the covering, or may be separate from the covering, and may comprise flaps. A spiral covering may also form the valve.

Abstract: The present embodiments relate to a novel clamping assembly. More specifically, present embodiments relate to a clamping assembly for blind flange installation which provides an air tight seal for piping applications including, but not limited to, low pressure high-density polyethylene (HDPE) piping applications.

Abstract: Disclosed herein is a system for indexing a workpiece. The system comprises a vacuum source and a fixture plate, fluidly coupled with the vacuum source. The system also comprises an indexing stop, coupled to the fixture plate and fluidly coupled with the vacuum source. The indexing stop is actuatable between an extended position and a retracted position relative to the fixture plate. The vacuum source is selectively operable to concurrently apply a suction force to a workpiece supported on the fixture plate to urge the workpiece against the fixture plate and to the indexing stop to actuate the indexing stop from the extended position to the retracted position.

Abstract: Methods and systems for implementing a highly available distributed queue using replicated messages are disclosed. An enqueue request is received from a client at a particular queue host of a plurality of queue hosts. The enqueue request comprises a message and a replica count greater than one. One or more copies of a replication request are sent from the particular queue host to one or more additional queue hosts. The replication request comprises the message. The quantity of copies of the replication request is determined based at least in part on the replica count. An initial replica of the message is enqueued at the particular queue host. One or more additional replicas of the message are enqueued at the one or more additional queue hosts. A quantity of the one or more additional replicas is determined based at least in part on the replica count.

Abstract: Techniques and system configurations for tracking customers and employees in a commercial environment such as a retail store are described herein. Customer devices that are operated by an associated customer may be tracked to determine customer shopping activities in a retail store, and to obtain promotions or affect targeted results based on the customer's activity and a profile associated with the customer. Employee devices that are operated by an associated employee also may be tracked to identify employee activities and manage the interactions that occur with customers in the retail environment. In-store activities and interactions accordingly may be enhanced as a result of advertising, marketing, and analytics derived from the tracked activities.

Abstract: An example of a method of making a printed structure comprises providing a destination substrate, contact pads disposed on the destination substrate, and a layer of adhesive disposed on the destination substrate. A stamp with a component adhered to the stamp is provided. The component comprises a stamp side in contact with the stamp and a post side opposite the stamp side, a circuit, and connection posts extending from the post side. Each of the connection posts is electrically connected to the circuit. The component is pressed into contact with the adhesive layer to adhere the component to the destination substrate and to form a printed structure having a volume defined between the component and the destination substrate. The stamp is removed and the printed structure is processed to fill or reduce the volume.

Abstract: A NOx adsorber catalyst and its use in an emission treatment system for internal combustion engines, is disclosed. The NOx adsorber catalyst comprises a first layer consisting essentially of a support material, one or more platinum group metals disposed on the support material, and a NOx storage material.

Abstract: A system and method for a self-adapting SDWAN to ensure compliance with client requirements. A SDWAN performance analyzer continuously monitors all of the nodes within an SDWAN, receiving a plurality of operational data regarding operational parameters of each node. Based on the operational data, a machine learning algorithm is applied to develop a tree-structure representative of a desired network configuration, based on the real-time state of the network, to ensure compliance with client requirements. The SDWAN performance analyzer can generate configuration commands to send to one or more of the nodes in the SDWAN to reconfigure the operational parameters of the nodes in line with the desired network configuration.

Abstract: Various embodiments disclosed herein provide for an enhanced timing advance scheme to support MU-MIMO in an integrated access and backhaul system. The timing advance scheme disclosed herein aligns the arrival time between backhaul links and access links to enable MU-MIMO gain at the receiver side. In the integrated access and backhaul system, which comprises distributed nodes, the timing advance offset for an access link transmission (a transmission to a node further away in hops from the core network, or to a user equipment device) can be modified by offsetting it with the timing advance of the backhaul link (e.g., from a parent node). This enables the arrival time for transmissions, both access link transmissions from the UE or child node, and backhaul link transmissions from a parent node to arrive at the same time.

Abstract: An agricultural air seeder planting unit incorporates control valves that split flow and change direction from supply to distribution hoses. The flow area of the control valves is automatically adjusted pneumatically by movement of a piston in response to total pressure to provide a uniform velocity flow from each of the control valves.

Abstract: In a method of observing users of communication devices, a central computer system recognizes a first user associated with a first communication device and a second user associated with a second communication device. The central computer system observes a communication between the first communication device and the second communication device, wherein at least a portion of the communication is an audible communication. The central computer system relays the communication between the first communication device and the second communication device. The central computer system identifies features of the communication and makes the features available for decision making purposes.

Abstract: A system for and method of verifying a configuration of an artifact, such as a gun, a phone, or other artifact, is provided. The system includes a plurality of unique verification mechanisms, each verification mechanism including a unique identifier for distinguishing the verification mechanism from each of the other verification mechanisms. The method includes engaging a verification mechanism with the artifact and/or with an object and/or device associated with the artifact so as to move the artifact to a verifiable configuration while simultaneously moving the verification mechanism to a verifying configuration. The method further includes scanning the verification mechanism to create a first verification record, thereby providing evidence of such configurations.

Abstract: The present invention relates to an improved formulation of danirixin in its hydrobromide salt form. This improved formulation can be an aqueous intravenous formulation containing danirixin or a lyophilized pharmaceutical solid composition containing danirixin to be reconstituted to provide a solution for intravenous administration.

Abstract: This invention concerns the transmitting and receiving of digital media packets, such as audio and video channels and lighting instructions. In particular, the invention concerns the transmitting and receiving of redundant media packet streams. Samples are extracted from a first and second media packet stream. The extracted samples are written to a buffer based on the output time of each sample. Extracted samples having the same output time are written to the same location in the buffer. Both media packet streams are simply processed all the way to the buffer without any particular knowledge that one of the packet streams is actually redundant. This simplifies the management of the redundant packet streams, such as eliminating the need for a “fail-over” switch and the concept of an “active stream”, The location is the storage space allocated to store one sample.

Abstract: A speaker system is disclosed with user-selectable output modes including controlled directivity output modes (e.g. selectable monopole, dipole, or cardioid radiation patterns), that may be implemented with adjustable electronic delay of out-of-phase driver elements, and that provides for both even-orderharmonic distortion reduction and driver force cancellation in a compact assembly suitable for home or studio use.

Abstract: Provided are computer-implemented methods and systems for implementing and utilizing an audio and visual asset matching platform. The audio and visual asset matching platform may include a first interface, a digital asset creation platform, an asset matching engine, and a user feedback engine. The first interface may be configured to select at least one master digital asset. The digital asset creation platform may be configured to create digital assets, the digital assets comprising at least one of text, audio, image, video, 3D/4D virtual environments, and animation files and metadata. The asset matching engine may be configured to match digital assets and generate at least one output digital asset. The user feedback engine may be configured to monitor and analyze behavior in response to receipt of at least one output digital asset and generate feedback metrics to improve the matching of the asset matching engine.

Abstract: An improved technique for acoustic sensing involves, in one embodiment, launching into a medium, a plurality of groups of pulse-modulated electromagnetic-waves. The frequency of electromagnetic waves in a pulse within a group differs from the frequency of the electromagnetic waves in another pulse within the group. The energy scattered by the medium is detected and, in one embodiment, may be used to determine a characteristic of the environment of the medium. For example, if the medium is a buried optical fiber into which light pulses have been launched in accordance with the invention, the presence of acoustic waves within the region of the buried fiber can be detected.

Abstract: A hybrid imaging system is disclosed including an arcuate arm defining a first and a second end the arcuate arm including a first detector assembly for 2D x-ray imaging of a patient and a second detector assembly for CT imaging of the patient, wherein the imaging system includes an internal drive mechanism for rotating the arcuate arm (e.g. translating the arcuate arm along an arcuate path) around the patient.