Abstract: The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3? end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Abstract: The present disclosure relates to a vehicle interface device configured to output a haptic signal to indicate a potential hazard. The apparatus includes at least one haptic generator configured to generate a haptic signal; and a processor for controlling the haptic generator. The processor is configured to determine an angular position of the identified object relative to the vehicle in dependence on object data relating to an identified object representing a potential hazard. A control signal is generated to cause the haptic generator to output a haptic signal for providing an indication of the determined relative position of the identified object. The control signal is modified to progressively change the generated haptic signal to represent changes in the relative angular position of the identified object. The present disclosure also relates to a vehicle incorporating a vehicle interface device.

Abstract: Aspects described herein relate to a base station for providing air-to-ground wireless communication over various altitudes. The base station includes a first antenna array comprising one or more antennas configured to form a first cell coverage area extending substantially from a horizon up to a first elevation angle away from the first antenna array to a predetermined distance from the first antenna array. The base station further includes a second antenna array configured at an uptilt elevation angle to form a second cell coverage area extending at least from the first elevation angle to a second elevation away from the second antenna array, wherein the first cell coverage area and the second cell coverage area are concentric to define the ATG cell at least to the predetermined distance and up to a predetermined elevation.

Abstract: A method of detecting overcurrent events within at least one electronic device, and an overcurrent detection module therefor. The method comprises receiving at least one current requirement indication from at least one electronic device, determining at least one overcurrent value based at least partly on the received at least one current requirement indication, receiving at least one indication of at least one input current flow for the at least one electronic device, and determining that an overcurrent event is occurring if the indicated at least one input current flow for the at least one electronic device exceeds the determined at least one overcurrent value.

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

Abstract: A combustor assembly for a gas turbine engine is includes a liner and a combustor dome formed of a ceramic matrix composite material. The combustor dome and liner together define at least in part a combustion chamber. The combustor dome extends along a circumferential direction and defines one or more openings, the combustor dome is configured to receive one or more fuel-air injector hardware assemblies in or through the one or more openings.

Abstract: A wound treatment system includes a housing. A processor is located in the housing. A pressure monitoring system is coupled to the processor. A power delivery system is located in the housing and coupled to the processor. An oxygen concentrator is located in the housing and coupled to the power delivery system. The oxygen concentrator includes a plurality of oxygen outlets. The processor is configured to receive pressure information from the pressure monitoring system that is indicative of a pressure in a restricted airflow enclosure provided by a dressing and located adjacent a wound site; and use the pressure information to control the power provided from the power delivery system to the oxygen concentrator in order to control an oxygen flow created by the oxygen concentrator and provided through one of the plurality of oxygen outlets to the restricted airflow enclosure.

Abstract: A first data item is encrypted at a client device using a first encryption key. The encrypted first data item is included in a data object. A second encryption key is received at the client device from a key management device. The first encryption key is encrypted using the second encryption key. The encrypted first encryption key is included in the data object, and the data object is stored at a storage device.

Abstract: Methods, systems, and apparatus, including an apparatus for processing an instruction for accessing a N-dimensional tensor, the apparatus including multiple tensor index elements and multiple dimension multiplier elements, where each of the dimension multiplier elements has a corresponding tensor index element. The apparatus includes one or more processors configured to obtain an instruction to access a particular element of a N-dimensional tensor, where the N-dimensional tensor has multiple elements arranged across each of the N dimensions, and where N is an integer that is equal to or greater than one; determine, using one or more tensor index elements of the multiple tensor index elements and one or more dimension multiplier elements of the multiple dimension multiplier elements, an address of the particular element; and output data indicating the determined address for accessing the particular element of the N-dimensional tensor.

Abstract: A data processing apparatus is provided including queue circuitry to respond to control signals each associated with a memory access instruction, and to queue a plurality of requests for data, each associated with a reference to a storage location. Resolution circuitry acquires a request for data, and issues the request for data, the resolution circuitry having a resolution circuitry limit. When a current capacity of the resolution circuitry is below the resolution circuitry limit, the resolution circuitry acquires the request for data by receiving the request for data from the queue circuitry, stores the request for data in association with the storage location, issues the request for data, and causes a result of issuing the request for data to be provided to said storage location.

Abstract: A handle assembly for opening and closing a vehicle door wherein the handle assembly includes: a recess in an exterior surface of the vehicle door; a cover over the recess wherein the cover is coupled to the vehicle door and is moveable between an open position and a closed position; and a handle member coupled to the cover and retained in the recess when the cover is in the closed position and released from the recess when the cover is in the open position.

Abstract: A camera system is configured to capture 360 degree image information of a local area, at least a portion of which is in stereo. The camera system includes a plurality of peripheral cameras, a plurality of axis cameras, a first rigid plate, and a second rigid plate, each aligned along an alignment axis. The peripheral cameras are arranged in a ring configuration that allows objects in the local area past a threshold distance to be within the fields of view of at least two peripheral cameras. The first and second rigid plates secure to a top and a bottom surface of the ring of peripheral cameras, respectively. At least one axis camera is arranged along the alignment axis and is coupled perpendicularly to a surface of the first rigid plate.

Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.

Abstract: Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, at least a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is at least partially filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

Abstract: A reciprocating saw blade for use with a reciprocating saw, the saw blade including a body including a first substantially planar surface and a second substantially planar surface opposite the first surface, an attachment portion for coupling the saw blade to the reciprocating saw, a cutting edge including a plurality of cutting teeth, and a rib element including a pair of outermost rib members. One of the outermost rib members is proximate the cutting edge and the other of the outermost rib members is proximate a back edge of the blade opposite the cutting edge. Each outermost rib member includes a first portion and a second portion. The first portions of each of the ribs are substantially parallel to one another.

Abstract: Methods and apparatus for monitoring a dock leveler are disclosed herein. One example dock leveler system for use at a doorway of a loading dock, where a body is sometimes present at the loading dock, includes a deck movable between a raised position and a lowered position. The example dock leveler system also includes a sensor having a field of view extending over the deck when the deck is in the lowered position. The sensor is in a normal state when the deck is in the lowered position while the body is off the deck, the sensor is in a triggered state when the deck is in the lowered position while the body is on the deck interrupting the field of view, and the sensor is in the triggered state when the deck is in the raised position with the deck interrupting the field of view regardless of whether the body is on or off the deck.

Abstract: A system and a method are described for monitoring a medical care environment. In one or more implementations, a method includes identifying a plurality of potential locations within a field of view of a camera as representing a bed and/or a seating platform. The method also includes identifying a first subset of pixels from the plurality of potential locations as representing a bed and/or a seating platform. The method also includes identifying a second subset of pixels within the field of view of the camera as representing an object (e.g., a subject, such as a patient, medical personnel; bed; chair; patient tray; medical equipment; etc.) proximal to the bed and/or seating platform. The method also includes determining an orientation of the object with respect to the bed and/or seating platform. In implementations, the method further includes issuing an electronic communication alert based upon the orientation of the object.

Abstract: A system and method for sensing an edge of a region includes at least one distance sensor configured to detect a plurality of distances of objects along a plurality of adjacent scan lines. A controller is in communication with the at least one distance sensor and is configured to determine a location of an edge of a region within the plurality of adjacent scan lines. The controller includes a comparator module configured to compare values corresponding to the detected plurality of distances, and an identification module configured to identify the location of the edge of the region according to the compared values. In one example, the values corresponding to the detected plurality of distances include couplets of standard deviations that are analyzed and selected to identify the location of the edge.

Abstract: An illustrative anchoring mechanism is provided for attachment to an implantable subcutaneous lead to facilitate anchoring at the distal tip of the lead. The anchoring mechanism is attached to an opening in a distal portion of a subcutaneous lead prior to implantation. The anchoring mechanism may be designed to avoid covering the sensing electrode of the subcutaneous lead, to prevent interference with sensing. Use of such an apparatus may reduce the number of incisions needed to perform implantation.

Abstract: A silicon-on-insulator chip including an arrayed waveguide grating (AWG) and an array of detector remodulators (DRMs) in a planar arrangement with the AWG such that the modulators or modulators and detectors of said DRMs are located within the same plane as the waveguides of the AWG; and wherein each DRM is located at an input or output of the AWG.